公开(公告)号：US20240077431A1

公开(公告)日：2024-03-07

申请号：US18384361

申请日：2023-10-26

申请人： IDEXX Laboratories, Inc.

发明人： David C. Giroux ,  Nathanael Williams

IPC分类号： G01N21/956 ,  G01N35/00

CPC分类号： G01N21/956 ,  G01N35/00623 ,  G01N2035/00673

摘要： A Z-axis measurement fixture used for testing whether a chemical reagent test slide exhibits Z-axis variability, which may affect measurements performed by an automated chemical analyzer using such test slides, includes a planar main body that holds three stainless steel balls, each ball having a known and calibrated diameter. Portions of the stainless steel balls extend outwardly from the top wall and the bottom wall of the planar main body. A chemical reagent test slide is placed on the fixture to rest on and be supported at three points by the portions of the stainless steel balls which project outwardly from the top wall of the planar main body. The fixture is placed on the surface of a gauge block of an optical measurement system such that the lower portions of the three stainless steel balls will rest on the gauge block of the optical measurement system.

公开(公告)号：US11905546B2

公开(公告)日：2024-02-20

申请号：US17474918

申请日：2021-09-14

申请人： IDEXX Laboratories Inc.

发明人： Daniel H. Broder ,  Lawrence G. Chapper ,  Veronica L. Newport ,  Julie E. Rollins ,  Brian M. Swalla ,  Scott W. Wagner ,  David L. White

IPC分类号： C12Q1/04 ,  C12M1/32 ,  C12M1/04 ,  B01L3/00

CPC分类号： C12Q1/04 ,  B01L3/50853 ,  C12M23/12 ,  C12M23/24 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2200/16 ,  B01L2300/048 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2300/126

摘要： A sample testing apparatus includes a sample tray defining a planar surface and a plurality of wells recessed relative to the planar surface, and a lid member configured to be sealed about the planar surface of the sample tray. The lid member includes an adhesive layer configured to be sealed to the planar surface of the sample tray, a breathable film layer disposed about the adhesive layer, and a backing layer disposed about the breathable film layer. Methods of using the sample testing apparatus for testing a sample and kits to facilitate such testing are also provided.

公开(公告)号：US20240053367A1

公开(公告)日：2024-02-15

申请号：US18222429

申请日：2023-07-15

申请人： IDEXX Laboratories, Inc.

发明人： Murthy VSN Yerramilli ,  Mahalakshmi Yerramilli ,  Edward Obare ,  Daniel Wayne Patch

IPC分类号： G01N33/72 ,  G01N21/33 ,  G01N30/86 ,  C12Q1/32

CPC分类号： G01N33/72 ,  G01N21/33 ,  G01N30/8675 ,  C12Q1/32 ,  G01N2333/904

摘要： Methods and devices for determining the hematocrit of blood samples.

公开(公告)号：US20230305262A1

公开(公告)日：2023-09-28

申请号：US18203169

申请日：2023-05-30

申请人： IDEXX Laboratories Inc.

发明人： Garland Christian Misener ,  Michael Ryan Moon ,  Spencer Franklin McElwain ,  Alan Papale

IPC分类号： G02B7/02 ,  G01N15/02 ,  G01N15/14 ,  G02B27/30 ,  G02B19/00 ,  G02B27/09

CPC分类号： G02B7/021 ,  G01N15/0205 ,  G01N15/1434 ,  G02B27/30 ,  G02B19/0052 ,  G02B27/0966

摘要： A flow cytometer, laser optics assembly thereof, and methods of assembling the same are provided. The flow cytometer is capable of yielding consistent and accurate results despite exposure to adverse environmental conditions such as, for example, temperature changes within a relatively wide temperature range and/or a relatively large amount of random-axis mechanical vibration. The flow cytometer of the present disclosure is additionally or alternatively relatively insensitive to real or apparent core stream shifts, employs a slowly converging beam along the axis perpendicular to core stream flow, and provides the ability to precisely measure time-of-flight.

公开(公告)号：US20230243852A1

公开(公告)日：2023-08-03

申请号：US18160000

申请日：2023-01-26

申请人： IDEXX LABORATORIES, INC.

发明人： Sarah Maier PETERSON ,  Yerramilli V.S.N. MURHTY

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N2333/775 ,  G01N2333/8139 ,  G01N2800/56 ,  G01N2800/347

摘要： The disclosure provides methods and compositions for detection and differentiation of stable CKD and progressive CKD in mammals.

公开(公告)号：US11618915B2

公开(公告)日：2023-04-04

申请号：US16193695

申请日：2018-11-16

申请人： IDEXX Laboratories Inc.

发明人： Daniel H. Broder ,  Lawrence G. Chapper ,  Veronica L. Newport ,  Julie E. Rollins ,  Brian M. Swalla ,  Scott W. Wagner ,  David L. White

IPC分类号： C12M1/32 ,  C12M1/04 ,  C12Q1/04 ,  B01L3/00

摘要： A sample testing apparatus includes a sample tray defining a planar surface and a plurality of wells recessed relative to the planar surface, and a lid member configured to be sealed about the planar surface of the sample tray. The lid member includes an adhesive layer configured to be sealed to the planar surface of the sample tray, a breathable film layer disposed about the adhesive layer, and a backing layer disposed about the breathable film layer. Methods of using the sample testing apparatus for testing a sample and kits to facilitate such testing are also provided.

公开(公告)号：US11435365B2

公开(公告)日：2022-09-06

申请号：US16571345

申请日：2019-09-16

申请人： IDEXX Laboratories, Inc.

发明人： Mahalakshmi Yerramilli ,  Michael Randolph Atkinson ,  Murthy V. S. N. Yerramilli

IPC分类号： G01N33/68 ,  G01N33/53 ,  G01N33/92

摘要： This invention provides reagents and methods for diagnosing renal disease. Differential levels of inosine metabolite, and proteins: apolipoprotein C-I, apolipoprotein C-II, fibrinogen alpha chain, or fibrinogen A-alpha chain, kininogen, Inter-Alpha Inhibitor H4 (ITIH4), keratin Type I cytoskeletol 10 cystatin A, cystatin B and other polypeptides and fragments thereof provide biomarkers of renal disease and are described herein.

公开(公告)号：US20220196672A1

公开(公告)日：2022-06-23

申请号：US17554557

申请日：2021-12-17

申请人： IDEXX LABORATORIES, INC.

发明人： Joshua Michael BOUCHER ,  Anton MESTEK, JR. ,  Clever MADRID ,  Jesse Stephen BUCH

IPC分类号： G01N33/68 ,  G01N33/569 ,  C07K14/29

摘要： Provided herein are compositions and methods for detection and treatment of Rocky Mountain spotted fever (“RMSF”). The compositions specifically detect Rickettsia rickettsii and do not cross-react with other Rickettsia species providing rapid and accurate detection and diagnosis of RMSF.

公开(公告)号：US20220099594A1

公开(公告)日：2022-03-31

申请号：US17490461

申请日：2021-09-30

申请人： IDEXX Laboratories, Inc.

发明人： David C. Giroux ,  Nathanael Williams

IPC分类号： G01N21/956 ,  G01N35/00

摘要： A Z-axis measurement fixture used for testing whether a chemical reagent test slide exhibits Z-axis variability, which may affect measurements performed by an automated chemical analyzer using such test slides, includes a planar main body that holds three stainless steel balls, each ball having a known and calibrated diameter. Portions of the stainless steel balls extend outwardly from the top wall and the bottom wall of the planar main body. A chemical reagent test slide is placed on the fixture to rest on and be supported at three points by the portions of the stainless steel balls which project outwardly from the top wall of the planar main body. The fixture is placed on the surface of a gauge block of an optical measurement system such that the lower portions of the three stainless steel balls will rest on the gauge block of the optical measurement system.

公开(公告)号：US20210278431A1

公开(公告)日：2021-09-09

申请号：US17195020

申请日：2021-03-08

申请人： IDEXX Laboratories, Inc.

发明人： Jesse Daniel Faller ,  Robert W. Lachapelle ,  Dominic Pelletier

IPC分类号： G01N35/10

摘要： An insert mounted in a mixing cup and used by an automated chemical analyzer for removing a targeted component of a liquid sample includes a porous matrix formed of or carrying in an immobilized state functionalized particles having properties such that the targeted component of the liquid sample adheres to the functionalized particles. When the liquid sample is expelled from a disposable tip fitted on the end of a pipette forming part of the automated chemical analyzer into the mixing cup, the liquid sample is drawn into the matrix of the insert by capillary action, whereupon the targeted component of the liquid sample adheres to the immobilized functionalized particles of the matrix.