公开(公告)号：US09545975B2

公开(公告)日：2017-01-17

申请号：US14623355

申请日：2015-02-16

申请人： David Rosen

发明人： David Rosen

IPC分类号： B62M25/08 ,  F16L3/12 ,  B62M25/04

CPC分类号： B62M9/127 ,  B62J99/00 ,  B62J2099/0046 ,  B62K23/02 ,  B62K23/06 ,  B62M25/04 ,  B62M25/045 ,  B62M25/08 ,  F16L3/1218 ,  Y10T74/20462

摘要： The present disclosure relates to devices and methods of converting a bicycle frame from a mechanical gear-shifting configuration to an electronic gear-shifting configuration and vice versa. In a representative embodiment, a method of converting a bicycle frame from a mechanical gear-shifting configuration to an electronic gear-shifting configuration comprises removing a mechanical cable extending between a mechanical gear-shift actuator and a mechanical gear shifter via a cable stop of a removable bracket member secured to a down tube member of the bicycle frame, and removing the removable bracket member from the down tube member of the bicycle frame. The method further comprises mounting an electronically-actuated gear shifter to the bicycle frame in electrical communication with an electronic gear-shift actuator such that actuation of the electronic gear-shift actuator causes the electronically-actuated gear shifter to shift gears.

摘要翻译： 本公开涉及将自行车车架从机械变速结构转换为电子换档配置的装置和方法，反之亦然。 在代表性的实施例中，一种将自行车车架从机械换档构型转换成电子变速构型的方法包括：经机械齿轮换档致动器和机械变速器之间延伸的机械缆索经由 可移动支架构件固定到自行车车架的下管构件，并且从自行车车架的下管构件移除可移除的支架构件。 该方法还包括将电子致动的换档器安装到与电子换档致动器电连通的自行车车架，使得电子变速执行器的致动使得电子致动的换档器移动齿轮。

公开(公告)号：US20130071271A1

公开(公告)日：2013-03-21

申请号：US13635582

申请日：2011-03-17

申请人： David Rosen ,  David Ku ,  Jane Kang

发明人： David Rosen ,  David Ku ,  Jane Kang

IPC分类号： F04B43/08 ,  F04B43/09

CPC分类号： F04B43/086 ,  F04B43/09 ,  F04B43/123 ,  F04B43/1292 ,  Y10T29/4924

摘要： A valveless, pulsatile, non-contact, positive displacement, finger-pump for pumping one or more fluids is disclosed. The pump can include one or more channels for holding one or more lengths of flexible tubing. The channels can include an adjustment mechanism and/or a resilient backing plate to reduce over compression of the tubing. The pump can utilize a plurality of profiled, pivoting fingers to sequentially occlude a length of tubing causing a pumping action. The fingers can be moved from the first position to the second position by a motor driven camshaft. Cam lobes disposed on the camshaft can be a modified eccentric design to improve tube occlusion and pump efficiency. At least one cam lobe can completely occlude the tubing at all times during operation to prevent backflow. The fingers can alternatively be moved from the first position to the second position by a variety of linear actuators.

摘要翻译： 公开了用于泵送一种或多种流体的无阀，脉动，非接触，正位移，指泵。 泵可以包括用于保持一段或多段柔性管的一个或多个通道。 通道可以包括调节机构和/或弹性背板，以减少管道的过度压缩。 泵可以利用多个成型的，枢转的指状物来顺序地封闭一段导管泵送作用的管道。 手指可以通过马达驱动的凸轮轴从第一位置移动到第二位置。 设置在凸轮轴上的凸轮凸角可以是改进的偏心设计，以改善管堵塞和泵效率。 在操作过程中，至少有一个凸轮凸起可以在任何时候完全堵塞管道，以防止回流。 手指可以通过各种线性致动器从第一位置移动到第二位置。

公开(公告)号：US20120157340A1

公开(公告)日：2012-06-21

申请号：US13384181

申请日：2011-06-09

申请人： Alessandra Cesano ,  Wendy J. Fantl ,  David Rosen

发明人： Alessandra Cesano ,  Wendy J. Fantl ,  David Rosen

IPC分类号： C40B30/04 ,  G01N33/559 ,  G01N33/566 ,  G01N27/26 ,  C12Q1/68 ,  G01N33/53

CPC分类号： G01N33/5041 ,  C12Q1/6886 ,  C12Q2600/112 ,  G01N2800/52 ,  G01N2800/7028

摘要： The present invention provides methods, compositions and kits for the characterization of cellular pathways in cells containing genetic alterations.

摘要翻译： 本发明提供用于在含有遗传改变的细胞中表征细胞途径的方法，组合物和试剂盒。

公开(公告)号：US20090029915A1

公开(公告)日：2009-01-29

申请号：US11926460

申请日：2007-10-29

申请人： Thomas Haberberger ,  David Rosen ,  Yoshinari Kumagai

发明人： Thomas Haberberger ,  David Rosen ,  Yoshinari Kumagai

IPC分类号： A61K38/16 ,  A61P19/10

CPC分类号： A61K38/1703 ,  Y02A50/473

摘要： A method is disclosed whereby levels of calcium, phosphate and parathyroid hormone are measured in a patient. The patient is treated with a formulation comprising a compound having phosphotonin activity and thereafter measurements are made again. Dosing of the formulation is adjusted based on measurements with measuring, administering and adjusting dosing continually repeated as needed.

公开(公告)号：US20090023634A1

公开(公告)日：2009-01-22

申请号：US11926726

申请日：2007-10-29

申请人： Thomas Haberberger ,  David Rosen ,  Yoshinari Kumagai

发明人： Thomas Haberberger ,  David Rosen ,  Yoshinari Kumagai

IPC分类号： A61K38/17 ,  A61P5/18

CPC分类号： A61K38/1703 ,  Y02A50/473

摘要： A method is disclosed whereby levels of calcium, phosphate and parathyroid hormone are measured in a patient. The patient is treated with a formulation comprising a compound having phosphotonin activity and thereafter measurements are made again. Dosing of the formulation is adjusted based on measurements with measuring, administering and adjusting dosing continually repeated as needed.

公开(公告)号：US20060166962A1

公开(公告)日：2006-07-27

申请号：US10538997

申请日：2003-12-08

申请人： Ping Ding ,  Robert Henrie ,  Daniel Lyga ,  John Lyga ,  David Rosen ,  Qun Zhang ,  Walter Yeager ,  Stephen Donovan ,  Steven Zhang ,  Inna Shulman ,  Guozhi Wang ,  Y Zhang ,  Ariamala Gopalsamy ,  Dennis Warkentin ,  Paul Rensner ,  Ian Silverman ,  Thomas Cullen

发明人： Ping Ding ,  Robert Henrie ,  Daniel Lyga ,  John Lyga ,  David Rosen ,  Qun Zhang ,  Walter Yeager ,  Stephen Donovan ,  Steven Zhang ,  Inna Shulman ,  Guozhi Wang ,  Y Zhang ,  Ariamala Gopalsamy ,  Dennis Warkentin ,  Paul Rensner ,  Ian Silverman ,  Thomas Cullen

IPC分类号： A61K31/501 ,  A61K31/496 ,  C07D487/04

CPC分类号： C07D405/14 ,  A01N43/40 ,  A01N43/54 ,  A01N43/713 ,  C07D211/14 ,  C07D211/18 ,  C07D211/22 ,  C07D211/24 ,  C07D211/26 ,  C07D211/28 ,  C07D211/32 ,  C07D211/94 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07D417/12 ,  C07D451/14 ,  C07D513/04

摘要： It has now been found that certain novel N-(substituted aryl)-4-(disubstituted methyl)piperidine and pyridine derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I): wherein m, n, q, r, and s are independently selected from 0 or 1; and p is 0, 1, 2, or 3; A is CH or N; and B, D, E, R, R1, R2, R3, R4, R5, R6, R7 and R8 are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I, and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

摘要翻译： 现在已经发现某些新的N-（取代的芳基）-4-（二取代的甲基）哌啶和吡啶衍生物提供了意想不到的杀虫活性。 这些化合物由式（I）表示：其中m，n，q，r和s独立地选自0或1; 且p为0,1,2或3; A是CH或N; 和B，D，E，R，R 1，R 2，R 3，R 4，R 本文中充分描述了本发明的第5，第6，第七和第八和第八。 此外，还公开了包含杀虫有效量的至少一种式I化合物和任选的有效量的至少一种第二化合物与至少一种与杀虫相容的载体的组合物; 以及控制昆虫的方法，包括将所述组合物施用于存在昆虫或预期存在的场所。

公开(公告)号：US20220226433A1

公开(公告)日：2022-07-21

申请号：US17486551

申请日：2021-09-27

申请人： Yoshinari Kumagai ,  Dawn McGuire ,  Meghan Miller ,  David Rosen

发明人： Yoshinari Kumagai ,  Dawn McGuire ,  Meghan Miller ,  David Rosen

IPC分类号： A61K38/18 ,  A61B5/055 ,  A61B5/00 ,  A61B6/03 ,  A61B6/00 ,  A61B8/08 ,  A61P19/02

摘要： A diagnostic and a method of treatment are disclosed whereby the diagnostic identifies patients more likely to respond to a therapeutic intervention thereby improving clinical benefits including improved joint function, reduced pain, and other clinical symptoms.

公开(公告)号：US10207771B2

公开(公告)日：2019-02-19

申请号：US15384012

申请日：2016-12-19

申请人： David Rosen

发明人： David Rosen

IPC分类号： B62M9/12 ,  B62M9/127 ,  B62M25/08 ,  F16L3/12 ,  B62K23/02 ,  B62J99/00 ,  B62K23/06 ,  B62M25/04

摘要： The present disclosure relates to devices and methods of converting a bicycle frame from a mechanical gear-shifting configuration to an electronic gear-shifting configuration and vice versa. In a representative embodiment, a method of converting a bicycle frame from a mechanical gear-shifting configuration to an electronic gear-shifting configuration comprises removing a mechanical cable extending between a mechanical gear-shift actuator and a mechanical gear shifter via a cable stop of a removable bracket member secured to a down tube member of the bicycle frame, and removing the removable bracket member from the down tube member of the bicycle frame. The method further comprises mounting an electronically-actuated gear shifter to the bicycle frame in electrical communication with an electronic gear-shift actuator such that actuation of the electronic gear-shift actuator causes the electronically-actuated gear shifter to shift gears.

公开(公告)号：US20160236751A1

公开(公告)日：2016-08-18

申请号：US14623355

申请日：2015-02-16

申请人： David Rosen

发明人： David Rosen

IPC分类号： B62M25/08 ,  F16L3/12

CPC分类号： B62M9/127 ,  B62J99/00 ,  B62J2099/0046 ,  B62K23/02 ,  B62K23/06 ,  B62M25/04 ,  B62M25/045 ,  B62M25/08 ,  F16L3/1218 ,  Y10T74/20462

摘要： The present disclosure relates to devices and methods of converting a bicycle frame from a mechanical gear-shifting configuration to an electronic gear-shifting configuration and vice versa. In a representative embodiment, a method of converting a bicycle frame from a mechanical gear-shifting configuration to an electronic gear-shifting configuration comprises removing a mechanical cable extending between a mechanical gear-shift actuator and a mechanical gear shifter via a cable stop of a removable bracket member secured to a down tube member of the bicycle frame, and removing the removable bracket member from the down tube member of the bicycle frame. The method further comprises mounting an electronically-actuated gear shifter to the bicycle frame in electrical communication with an electronic gear-shift actuator such that actuation of the electronic gear-shift actuator causes the electronically-actuated gear shifter to shift gears.

摘要翻译： 本公开涉及将自行车车架从机械变速结构转换为电子换档配置的装置和方法，反之亦然。 在代表性的实施例中，一种将自行车车架从机械换档构型转换成电子变速构型的方法包括：经机械齿轮换档致动器和机械变速器之间延伸的机械缆索经由 可移动支架构件固定到自行车车架的下管构件，并且从自行车车架的下管构件移除可移除的支架构件。 该方法还包括将电子致动的换档器安装到与电子换档致动器电连通的自行车车架，使得电子变速执行器的致动使得电子致动的换档器移动齿轮。

公开(公告)号：US08995344B2

公开(公告)日：2015-03-31

申请号：US13647054

申请日：2012-10-08

申请人： Drew Bertagna ,  David Rosen

发明人： Drew Bertagna ,  David Rosen

IPC分类号： H04W88/08 ,  H01Q3/24

CPC分类号： H04W28/0278 ,  H01Q3/242 ,  H04L49/9057 ,  H04W84/12 ,  H04W88/08 ,  H04W88/10

摘要： A wireless network access device comprising a radio interface with a serial communication line, a switch, and M serial connections to M connectors for connecting up to M corresponding detachable radio modules. The radio interface forms up to M individually addressable radio communications paths. Each radio module includes a radio configured to communicate with client devices in a coverage area and a radio processor configured to manage at least one radio receiving buffer. The radio receiving buffers store receiver buffer identifiers to corresponding received data space. A processor manages communication between the client devices that communicate with the radio modules and a data network via the radio interface and a network interface when N≦M radio modules are connected to the radio interface. An assist engine is connected in the serial connection between the processor and the switch to manage allocation of receive buffer identifiers to the radio modules.

摘要翻译： 一种无线网络接入装置，包括具有串行通信线路的无线电接口，开关和至M个连接器的M个串行连接器，用于连接多达M个相应的可拆卸无线电模块。 无线电接口形成多达M个可单独寻址的无线电通信路径。 每个无线电模块包括被配置为与覆盖区域中的客户端设备通信的无线电设备和被配置为管理至少一个无线电接收缓冲器的无线电处理器。 无线电接收缓冲器将接收器缓冲器标识符存储到对应的接收数据空间。 当无线电模块连接到无线电接口时，处理器经由无线电接口和网络接口管理与无线电模块通信的客户端设备和数据网络之间的通信。 辅助引擎在处理器和交换机之间的串行连接中连接以管理对无线电模块的接收缓冲器标识符的分配。