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11.发明授权公开(公告)号：US08486139B2
公开(公告)日：2013-07-16
申请号：US12530510
申请日：2008-03-07
IPC分类号： A61F2/14
CPC分类号： A61K35/12 , A61K35/44 , A61L27/3604 , A61L27/3687 , A61L27/3691 , A61L27/38 , A61L2430/40 , C12N5/0068 , C12N2533/90
摘要： It is intended to provide a method of preparing a decellularized soft tissue whereby swelling after an ultrahigh pressure treatment can be inhibited, etc. The above-described method of preparing a decellularized soft tissue comprises the application step wherein an ultrahigh hydrostatic pressure is applied to an isolated soft tissue in a medium to thereby disrupt cells in the soft tissue, and the removal step wherein the disrupted cells are removed. As the medium, use is made of an aqueous solution containing a water-soluble polysaccharide such as dextran.
摘要翻译： 本发明提供一种制备脱细胞软组织的方法，其中可以抑制超高压处理后的膨胀等。上述制备脱细胞软组织的方法包括施加步骤，其中将超高静水压力施加到 在培养基中分离的软组织，从而破坏软组织中的细胞，以及去除步骤，其中去除细胞。 作为介质，使用含有水溶性多糖如葡聚糖的水溶液。
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公开(公告)号：US20110223390A1
公开(公告)日：2011-09-15
申请号：US13120631
申请日：2009-09-25
申请人： Takao Hanawa , Yusuke Tsutsumi , Kwangwoo Nam , Akio Kishida , Hisatoshi Kobayashi , Chiaki Yoshikawa
发明人： Takao Hanawa , Yusuke Tsutsumi , Kwangwoo Nam , Akio Kishida , Hisatoshi Kobayashi , Chiaki Yoshikawa
CPC分类号： A61L27/34 , A61L27/04 , B05D1/185 , B05D1/283 , B05D2202/35 , B82Y30/00 , B82Y40/00 , C08F292/00 , C09D5/4476 , C25D11/16 , C25D11/26 , Y10T428/24752 , C08F220/28
摘要： Disclosed is a polymer brush composite including a substrate, a solid layer disposed on the substrate and containing at least one of a metal or a metal oxide, and a plurality of polymer chains penetrating the solid layer in such a manner that one end of each of the polymer chains is disposed on the upper side of the substrate and the other end of each the polymer chains is exposed at a surface of the solid layer on an opposite side of the solid layer to the substrate. The polymer brush composite exhibits good adhesion between an organic polymer compound and an inorganic material and has the surface the organic polymer compound and the inorganic material uniformly coexist.
摘要翻译： 公开了一种聚合物刷复合体，其包括基材，设置在基材上的，含有金属或金属氧化物中的至少一种的固体层，以及贯穿固体层的多个聚合物链， 聚合物链设置在基材的上侧，并且每个聚合物链的另一端在固体层的与基材相反的一侧的表面上暴露。 聚合物刷复合物在有机高分子化合物和无机材料之间表现出良好的粘附性，并且表面有机高分子化合物和无机材料均匀共存。
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13.发明授权Device and method for uniformly inoculating a substrate having three-dimensional surfaces 有权用于均匀接种具有三维表面的基材的装置和方法公开(公告)号：US07910360B2
公开(公告)日：2011-03-22
申请号：US10568701
申请日：2004-08-18
申请人： Toshiya Fujisato , Takuro Kogoshi , Yusuke Suga , Akio Kishida , Takeshi Nakatani , Soichiro Kitamura
发明人： Toshiya Fujisato , Takuro Kogoshi , Yusuke Suga , Akio Kishida , Takeshi Nakatani , Soichiro Kitamura
CPC分类号： C12M27/10
摘要： An apparatus and method for inoculating a biological substrate with cells include provision for rotating a container in which the substrate and a cell suspension are received about first and second axes of rotation. The apparatus comprises said container, first drive means for rotatably supporting the container about the first axis, and second drive means for rotatably supporting the first drive means about the second axis. The first and second axes of rotation do not lie in the same plane and extend in different directions so that the container revolves around the second axis while the container is rotating about the first axis. The inoculation method utilizes this apparatus.
摘要翻译： 用于用细胞接种生物底物的装置和方法包括提供用于旋转其中容纳基质和细胞悬浮液的容器绕第一和第二旋转轴旋转的装置。 该装置包括所述容器，用于围绕第一轴线可旋转地支撑容器的第一驱动装置和用于围绕第二轴线可旋转地支撑第一驱动装置的第二驱动装置。 第一和第二旋转轴线不位于相同的平面中并且在不同方向上延伸，使得当容器围绕第一轴线旋转时，容器围绕第二轴线旋转。 接种方法利用该装置。
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14.发明授权Method for controlling biological function with mechanical vibration and device therefor 失效用机械振动控制生物功能的方法及其装置公开(公告)号：US07468263B2
公开(公告)日：2008-12-23
申请号：US11069863
申请日：2005-02-28
申请人： Akio Kishida , Tsutomu Furuzono , Kozo Miyazaki , Toru Masuzawa
发明人： Akio Kishida , Tsutomu Furuzono , Kozo Miyazaki , Toru Masuzawa
摘要： Methods and apparatus for controlling biological functions with mechanical vibration are provided. Stimulation is applied to cells of one of an organism, bacteria or virus by mechanical vibration. The biological function comprises biological functions relating to cell growth. The biological functions relating to cell growth may include at least one of cell cultivation, cell proliferation, cell fusion, and cell differentiation.
摘要翻译： 提供了机械振动控制生物功能的方法和装置。 通过机械振动对生物体，细菌或病毒之一的细胞进行刺激。 生物学功能包括与细胞生长有关的生物功能。 与细胞生长有关的生物功能可以包括细胞培养，细胞增殖，细胞融合和细胞分化中的至少一种。
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公开(公告)号：US20090155760A1
公开(公告)日：2009-06-18
申请号：US10562833
申请日：2004-07-02
IPC分类号： A01N1/02
摘要： A method of injecting cells into a biological tissue comprising thrusting injection needle (200) under microvibration into tissue (5) secured by suction to tissue suction means (210) and effecting injection of a cell suspension into the tissue through the needle. There is also provided an apparatus for cell injection into the biological tissue.
摘要翻译： 将细胞注入生物组织中的方法，所述生物组织包括在微振动下的推进注射针（200）进入组织（5），所述组织通过抽吸固定到组织抽吸装置（210），并通过所述针实现细胞悬浮液注入所述组织。 还提供了用于细胞注入生物组织的装置。
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16.发明授权公开(公告)号：US09901601B2
公开(公告)日：2018-02-27
申请号：US14342293
申请日：2012-09-03
申请人： Akio Kishida , Seiichi Funamoto , Yoshihide Hashimoto , Jun Negishi , Souichiro Kuwa , Takao Ema , Kuniharu Kobayashi
发明人： Akio Kishida , Seiichi Funamoto , Yoshihide Hashimoto , Jun Negishi , Souichiro Kuwa , Takao Ema , Kuniharu Kobayashi
CPC分类号： A61K35/36 , A61K35/30 , A61K35/34 , A61L27/3604 , A61L27/362 , A61L27/3625 , A61L27/3691 , A61L2430/40
摘要： Provided are: a method for preparing a decellularized tissue product in which decellularized tissue can be filled with liquid while changes in the structure of support tissue constituting the decellularized tissue are inhibited; and a graft provided with a decellularized tissue product. The method for preparing a decellularized tissue product includes a reduced-pressure step for bringing an animal-derived decellularized tissue material and a liquid into contact under reduced-pressure conditions, and/or a pressurized step for bringing same into contact under pressurized conditions. The graft is provided with a decellularized tissue product prepared by the method of preparation.
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17.发明申请METHOD FOR PREPARING DECELLULARIZED TISSUE PRODUCT, AND GRAFT PROVIDED WITH DECELLULARIZED TISSUE PRODUCT 有权用于制备细长组织产品的方法和用细胞组织产品提供的片公开(公告)号：US20150157667A1
公开(公告)日：2015-06-11
申请号：US14342293
申请日：2012-09-03
申请人： Akio Kishida , Seiichi Funamoto , Yoshihide Hashimoto , Jun Negishi , Souichiro Kuwa , Takao Ema , Kuniharu Kobayashi
发明人： Akio Kishida , Seiichi Funamoto , Yoshihide Hashimoto , Jun Negishi , Souichiro Kuwa , Takao Ema , Kuniharu Kobayashi
CPC分类号： A61K35/36 , A61K35/30 , A61K35/34 , A61L27/3604 , A61L27/362 , A61L27/3625 , A61L27/3691 , A61L2430/40
摘要： Provided are: a method for preparing a decellularized tissue product in which decellularized tissue can be filled with liquid while changes in the structure of support tissue constituting the decellularized tissue are inhibited; and a graft provided with a decellularized tissue product. The method for preparing a decellularized tissue product includes a reduced-pressure step for bringing an animal-derived decellularized tissue material and a liquid into contact under reduced-pressure conditions, and/or a pressurized step for bringing same into contact under pressurized conditions. The graft is provided with a decellularized tissue product prepared by the method of preparation.
摘要翻译： 提供：一种制备脱细胞组织产品的方法，其中脱细胞组织可以被填充液体，同时抑制构成脱细胞组织的支持组织的结构的变化; 和设置有脱细胞组织产品的移植物。 制备脱细胞组织产品的方法包括用于使动物来源的脱细胞组织材料和液体在减压条件下接触的减压步骤和/或在加压条件下使其接触的加压步骤。 移植物具有通过制备方法制备的脱细胞组织产品。
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公开(公告)号：US08323881B2
公开(公告)日：2012-12-04
申请号：US10562833
申请日：2004-07-02
摘要： A method of injecting cells into a biological tissue comprising thrusting injection needle (200) under microvibration into tissue (5) secured by suction to tissue suction means (210) and effecting injection of a cell suspension into the tissue through the needle. There is also provided an apparatus for cell injection into the biological tissue.
摘要翻译： 将细胞注入生物组织中的方法，所述生物组织包括在微振动下的推进注射针（200）进入组织（5），所述组织通过抽吸固定到组织抽吸装置（210），并通过所述针实现细胞悬浮液注入所述组织。 还提供了用于细胞注入生物组织的装置。
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公开(公告)号：US07883864B2
公开(公告)日：2011-02-08
申请号：US10538716
申请日：2003-12-11
CPC分类号： A61L27/3691 , A61L27/3604 , A61L27/3683 , A61L27/3687 , A61L2430/40
摘要： A method of efficiently removing or fixing donor cells from a native tissue of mammalian origin comprises immersing the tissue in a treating solution, and irradiating the tissue with microwave while maintaining the temperature thereof in the range between 0° C. and 40° C.
摘要翻译： 从哺乳动物来源的天然组织有效地去除或固定供体细胞的方法包括将组织浸入处理溶液中，并用微波照射组织，同时将其温度保持在0℃至40℃的范围内。
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20.发明申请公开(公告)号：US20100145444A1
公开(公告)日：2010-06-10
申请号：US12530510
申请日：2008-03-07
CPC分类号： A61K35/12 , A61K35/44 , A61L27/3604 , A61L27/3687 , A61L27/3691 , A61L27/38 , A61L2430/40 , C12N5/0068 , C12N2533/90
摘要： It is intended to provide a method of preparing a decellularized soft tissue whereby swelling after an ultrahigh pressure treatment can be inhibited, etc. The above-described method of preparing a decellularized soft tissue comprises the application step wherein an ultrahigh hydrostatic pressure is applied to an isolated soft tissue in a medium to thereby disrupt cells in the soft tissue, and the removal step wherein the disrupted cells are removed. As the medium, use is made of an aqueous solution containing a water-soluble polysaccharide such as dextran.
摘要翻译： 本发明提供一种制备脱细胞软组织的方法，其中可以抑制超高压处理后的膨胀等。上述制备脱细胞软组织的方法包括施加步骤，其中将超高静水压力施加到 在培养基中分离的软组织，从而破坏软组织中的细胞，以及去除步骤，其中去除细胞。 作为介质，使用含有水溶性多糖如葡聚糖的水溶液。
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