-
公开(公告)号：US08465971B2
公开(公告)日：2013-06-18
申请号：US12214521
申请日：2008-06-18
申请人： Akio Kishida , Tsutomu Furuzono , Kozo Miyazaki , Toru Masuzawa
发明人： Akio Kishida , Tsutomu Furuzono , Kozo Miyazaki , Toru Masuzawa
摘要： Methods and apparatus for controlling biological functions with mechanical vibration are provided. Stimulation is applied to cells of one of an organism, bacteria or virus by mechanical vibration. The biological function comprises biological functions relating to cell growth. The biological functions relating to cell growth may include at least one of cell cultivation, cell proliferation, cell fusion, and cell differentiation.
-
2.发明申请Biological Tissue Bonding Device and Biological Tissue Bonding Medical Instrument 失效生物组织结合装置及生物组织结合医疗器械公开(公告)号：US20090105701A1
公开(公告)日：2009-04-23
申请号：US12224498
申请日：2007-03-01
申请人： Akio Kishida , Toru Masuzawa , Tetsuya Higami
发明人： Akio Kishida , Toru Masuzawa , Tetsuya Higami
CPC分类号： A61B17/320092 , A61B17/00491 , A61B2017/00504 , A61B2017/00969
摘要： A device 1a for bonding adherends T1 and T2, as a device for bonding biological tissue to biological tissue or a biological tissue bonding material, comprises: a clamping part 2a for clamping the adherends T1 and T2 between members 21a and 22a; a pressing part 3a for pressing the member 22a towards the member 21a; a pressure control part 4a for controlling the pressure by the pressing part 3a; a heating element 5a built into the member 21a; a heating control part 6a for controlling the heating by the heating element 5a; a vibration generating part 7a for generating microvibration; and a vibration control part 8a for controlling the microvibration generated by the vibration generating part 7a.
摘要翻译： 作为用于将生物体组织粘合到生物体组织或生物体组织接合材料上的装置，粘合被粘体T1和T2的装置1a包括：用于将被粘体T1和T2夹持在构件21a和22a之间的夹持部分2a; 用于将构件22a朝向构件21a按压的按压部3a; 用于通过按压部分3a控制压力的压力控制部分4a; 内置在构件21a中的加热元件5a; 用于控制加热元件5a的加热的加热控制部分6a; 用于产生微振动的振动产生部分7a; 以及用于控制由振动产生部7a产生的微振动的振动控制部8a。
-
公开(公告)号：US20060115900A1
公开(公告)日：2006-06-01
申请号：US10538716
申请日：2003-12-11
IPC分类号： C12N5/00
CPC分类号： A61L27/3691 , A61L27/3604 , A61L27/3683 , A61L27/3687 , A61L2430/40
摘要： A method of efficiently removing or fixing donor cells from a native tissue of mammalian origin comprises immersing the tissue in a treating solution, and irradiating the tissue with microwave while maintaining the temperature thereof in the range between 0° C. and 40° C.
摘要翻译： 从哺乳动物来源的天然组织有效地去除或固定供体细胞的方法包括将组织浸入处理溶液中，并用微波照射组织，同时将其温度保持在0℃至40℃的范围内。
-
4.发明授权Biological tissue bonding device and biological tissue bonding medical instrument 失效生物组织结合装置和生物组织结合医疗器械公开(公告)号：US08226636B2
公开(公告)日：2012-07-24
申请号：US12224498
申请日：2007-03-01
申请人： Akio Kishida , Toru Masuzawa , Tetsuya Higami
发明人： Akio Kishida , Toru Masuzawa , Tetsuya Higami
IPC分类号： A61B18/04
CPC分类号： A61B17/320092 , A61B17/00491 , A61B2017/00504 , A61B2017/00969
摘要： A device 1a for bonding adherends T1 and T2, as a device for bonding biological tissue to biological tissue or a biological tissue bonding material, comprises: a clamping part 2a for clamping the adherends T1 and T2 between members 21a and 22a; a pressing part 3a for pressing the member 22a towards the member 21a; a pressure control part 4a for controlling the pressure by the pressing part 3a; a heating element 5a built into the member 21a; a heating control part 6a for controlling the heating by the heating element 5a; a vibration generating part 7a for generating microvibration; and a vibration control part 8a for controlling the microvibration generated by the vibration generating part 7a.
摘要翻译： 作为用于将生物体组织粘合到生物体组织或生物体组织接合材料上的装置，粘合被粘体T1和T2的装置1a包括：用于将被粘体T1和T2夹持在构件21a和22a之间的夹持部分2a; 用于将构件22a朝向构件21a按压的按压部3a; 用于通过按压部分3a控制压力的压力控制部分4a; 内置在构件21a中的加热元件5a; 用于控制加热元件5a的加热的加热控制部分6a; 用于产生微振动的振动产生部分7a; 以及用于控制由振动产生部7a产生的微振动的振动控制部8a。
-
5.发明申请Heat-Generating Device, Heat-Generating Method and Biological Tissue-Bonding Device 审中-公开发热装置，发热方法和生物组织结合装置公开(公告)号：US20120136386A1
公开(公告)日：2012-05-31
申请号：US13375732
申请日：2010-06-02
申请人： Akio Kishida , Tsuyoshi Kimura , Seiichi Funamoto , Toru Masuzawa
发明人： Akio Kishida , Tsuyoshi Kimura , Seiichi Funamoto , Toru Masuzawa
CPC分类号： A61B17/00491 , A61B2017/00504 , A61B2017/320094 , A61B2018/0063
摘要： The present invention provides: a heat-generating device which includes a heat-generating unit 5a, having a resin member 10a which generates heat upon application of vibration and a vibration unit 11a which imparts vibration to the resin member 10a, and a heat generation control unit 6a which, by controlling the vibration generated by the vibration unit 11a, controls the heat generation of the heat-generating unit 5a in such a manner that the heat-generating unit 5a has a prescribed temperature; a heat-generating method utilizing this device; and a biological tissue-bonding device 1a utilizing the device.
摘要翻译： 本发明提供一种发热装置，其具有发热体单元5a，具有在施加振动时产生热量的树脂构件10a和向树脂构件10a施加振动的振动单元11a，以及发热控制 单元6a通过控制由振动单元11a产生的振动，以使发热单元5a具有规定温度的方式来控制发热单元5a的发热; 利用该装置的发热方法; 以及利用该装置的生物组织结合装置1a。
-
6.发明申请Method for controlling biological function with mechanical vibration and device therefor 失效用机械振动控制生物功能的方法及其装置公开(公告)号：US20090011494A1
公开(公告)日：2009-01-08
申请号：US12214521
申请日：2008-06-18
申请人： Akio Kishida , Tsutomu Furuzono , Kozo Miyazaki , Toru Masuzawa
发明人： Akio Kishida , Tsutomu Furuzono , Kozo Miyazaki , Toru Masuzawa
摘要： Methods and apparatus for controlling biological functions with mechanical vibration are provided. Stimulation is applied to cells of one of an organism, bacteria or virus by mechanical vibration. The biological function comprises biological functions relating to cell growth. The biological functions relating to cell growth may include at least one of cell cultivation, cell proliferation, cell fusion, and cell differentiation.
摘要翻译： 提供了机械振动控制生物功能的方法和装置。 通过机械振动对生物体，细菌或病毒之一的细胞进行刺激。 生物学功能包括与细胞生长有关的生物功能。 与细胞生长有关的生物功能可以包括细胞培养，细胞增殖，细胞融合和细胞分化中的至少一种。
-
7.发明申请Device and method for uniformly inoculating a substrate having three-dimensional surfaces 有权用于均匀接种具有三维表面的基材的装置和方法公开(公告)号：US20070166818A1
公开(公告)日：2007-07-19
申请号：US10568701
申请日：2004-08-18
申请人： Toshiya Fujisato , Takuro Kogoshi , Yusuke Suga , Akio Kishida , Takeshi Nakatani , Soichiro Kitamura
发明人： Toshiya Fujisato , Takuro Kogoshi , Yusuke Suga , Akio Kishida , Takeshi Nakatani , Soichiro Kitamura
CPC分类号： C12M27/10
摘要： An apparatus and method for inoculating a biological substrate with cells include provision for rotating a container in which the substrate and a cell suspension are received about first and second axes of rotation. The apparatus comprises said container, first drive means for rotatably supporting the container about the first axis, and second drive means for rotatably supporting the first drive means about the second axis. The first and second axes of rotation do not lie in the same plane and extend in different directions so that the container revolves around the second axis while the container is rotating about the first axis. The inoculation method utilizes this apparatus.
摘要翻译： 用于用细胞接种生物底物的装置和方法包括提供用于旋转其中容纳基质和细胞悬浮液的容器绕第一和第二旋转轴旋转的装置。 该装置包括所述容器，用于围绕第一轴线可旋转地支撑容器的第一驱动装置和用于围绕第二轴线可旋转地支撑第一驱动装置的第二驱动装置。 第一和第二旋转轴线不位于相同的平面中并且在不同方向上延伸，使得当容器围绕第一轴线旋转时，容器围绕第二轴线旋转。 接种方法利用该装置。
-
8.发明申请Method for controlling biological function with mechanical vibration and device therefor 失效用机械振动控制生物功能的方法及其装置公开(公告)号：US20050153437A1
公开(公告)日：2005-07-14
申请号：US11069863
申请日：2005-02-28
申请人： Akio Kishida , Tsutomu Furuzono , Kozo Miyazaki , Toru Masuzawa
发明人： Akio Kishida , Tsutomu Furuzono , Kozo Miyazaki , Toru Masuzawa
IPC分类号： C12N15/02 , C12M1/00 , C12M1/42 , C12M3/00 , C12N1/00 , C12N1/21 , C12N5/00 , C12N5/06 , C12N7/00 , C12N13/00 , C12N15/87
摘要： To provide a new method for controlling biological functions such that proliferation of cells is obtained even without using a growth factor or even when the amount thereof used is remarkably reduced and differentiation is induced by promoting an intracellular reaction of the cells or tissues and further a new gene can be transduced, etc. The method for controlling the biological functions with the mechanical vibration is to apply stimulation to the tissues or cells of an organism, bacteria or viruses with the mechanical vibration.
摘要翻译： 提供一种控制生物功能的新方法，即使不使用生长因子，甚至当其使用量显着降低并且通过促进细胞或组织的细胞内反应诱导分化时，获得细胞增殖， 基因可以转导等。用机械振动控制生物功能的方法是用机械振动对生物体，细菌或病毒的组织或细胞施加刺激。
-
公开(公告)号：US06387414B1
公开(公告)日：2002-05-14
申请号：US09368960
申请日：1999-08-05
申请人： Mitsuru Akashi , Tetsushi Taguchi , Akio Kishida , Akio Hayashi
发明人： Mitsuru Akashi , Tetsushi Taguchi , Akio Kishida , Akio Hayashi
IPC分类号： A61K3342
CPC分类号： A61K9/0024 , A61L27/46
摘要： A method for preparing a hydroxyapatite composite is disclosed. This method comprises alternately soaking a matrix which has been made hydrophilic at least on its surface, in a calcium ion aqueous solution containing calcium ions and substantially free of phosphate ions and in a phosphate ion aqueous solution containing phosphate ions and substantially free of calcium ions to securely form hydroxyapatite at least on the surface of the matrix. Also disclosed is a biocompatible material composed of the hydroxyapatite composite obtained by the method.
-
10.发明授权Fine grain carriers and medicinal composition prepared with the use of the same 失效精细的颗粒载体和使用相同的药物组合物公开(公告)号：US06368631B1
公开(公告)日：2002-04-09
申请号：US09452371
申请日：1999-12-01
申请人： Mitsuru Akashi , Akio Kishida , Shinji Sakuma , Hiroshi Kikuchi
发明人： Mitsuru Akashi , Akio Kishida , Shinji Sakuma , Hiroshi Kikuchi
IPC分类号： A61K914
CPC分类号： A61K47/32 , A61K9/1635
摘要： The present invention is directed to particulate carriers useful as drug carriers in a drug delivery system (DDS) and to pharmaceutical compositions making use of such carriers. The invention is characterized by the use, as the particulate carrier, of: graft copolymer (A) whose graft chain is poly N-alkylacrylamide chain, poly N-alkylmethacrylamide chain, etc.; and a composition containing a combination of the graft copolymer (A) and at least one graft copolymers selected from the group consisting of graft copolymers (B-1) having polyacrylic acid or polymethacrylic acid as the graft chain and graft copolymers (B-2) having a polyvinyl amine compound as the graft chain.
摘要翻译： 本发明涉及用作药物递送系统（DDS）中的药物载体的颗粒载体和利用这种载体的药物组合物。 本发明的特征在于使用接枝共聚物（A）作为颗粒载体，其接枝链是聚N-烷基丙烯酰胺链，聚N-烷基甲基丙烯酰胺链等; 和含有接枝共聚物（A）和至少一种选自具有聚丙烯酸或聚甲基丙烯酸作为接枝链的接枝共聚物（B-1）和接枝共聚物（B-2）的组合的组合物， 具有聚乙烯胺化合物作为接枝链。
-
-
-
-
-
-
-
-
-
搜索结果
25 条记录 (耗时 0.017 秒)
