公开(公告)号：US11492417B2

公开(公告)日：2022-11-08

申请号：US16579321

申请日：2019-09-23

Applicant: AMGEN INC.

Inventor： Hailing Hsu ,  Ming Zhang ,  Gunasekaran Kannan ,  Frederick Jacobsen ,  Wayne Tsuji

IPC: C07K16/28 ,  C07K16/46 ,  A61P37/06 ,  A61P19/02 ,  A61P29/02 ,  A61K39/395 ,  C07K16/18 ,  C07K16/24 ,  A61K39/00

Abstract: Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.

公开(公告)号：US11492372B2

公开(公告)日：2022-11-08

申请号：US17554865

申请日：2021-12-17

Applicant: AMGEN INC.

Inventor： Samuel Ray Trejo ,  Robert Perry Brake

IPC: B01D15/36 ,  B01D15/38 ,  C07K1/18 ,  C07K16/00 ,  C07K1/22 ,  C07K14/705 ,  C07K14/715 ,  B01D15/18

Abstract: The invention provides for the removal of a large fraction of contaminants from protein preparations while maintaining a high level of recovery using tentacle anion exchange matrix chromatography medium. Using the methods of the invention, leached affinity chromatography contaminants can be removed from recombinant protein preparations.

公开(公告)号：US20220347398A1

公开(公告)日：2022-11-03

申请号：US17621135

申请日：2020-06-16

Applicant: AMGEN INC.

Inventor： Sivakumar Paramanandam ,  Andrew Coles ,  Keng-Tong See ,  Desheng Yin

IPC: A61M5/50

Abstract: This disclosure describes a drug delivery device with communication functionality for purposes of transferring information to a user device, such as a smartphone, while maintaining power-efficient operation. The drug delivery device comprises a controller configured to, while operating in the active mode, use one or more sensors to detect that the injection mechanism has performed an injection. The controller is also configured to generate in memory a data entry indicative of the injection and/or a state of the drug delivery device, and switch into the low-power mode subsequent to or contemporaneous with detecting that the injection mechanism has performed the injection. The drug delivery device also comprises a wireless communication module powered by the power source and configured to establish a wireless connection with and transfer a message to a user device while the controller is operating in the low-power mode.

公开(公告)号：US20220340911A1

公开(公告)日：2022-10-27

申请号：US17634708

申请日：2020-08-13

Applicant: AMGEN INC.

Inventor： Wei GU ,  Essa Hu HARRINGTON ,  Oliver HOMANN

IPC: C12N15/113 ,  C12N15/10 ,  A61K47/00

Abstract: The present invention relates to RNAi constructs for reducing expression of the SLC30A8 gene. Methods of using such RNAi constructs to treat or prevent disease, such as pre-diabetes or diabetes are also described.

公开(公告)号：US20220340326A1

公开(公告)日：2022-10-27

申请号：US17760819

申请日：2020-10-06

Applicant: AMGEN INC.

Inventor： James Nakamura ,  Todd J. Manley ,  Trevor Raymond Lowe ,  Jasmine Malvar ,  Kenneth Tan

IPC: B65D5/50 ,  B65B5/06 ,  B65B5/04 ,  B65B55/00

Abstract: A package for a pharmaceutical product and method of assembly is described that includes a subassembly with a body including a main panel and legs depending downwardly from opposite edges of the main panel, and a sheet of plastic having opposite ends fixed to the body with the sheet of plastic at least partially extending over the main panel. The sheet of plastic is configured to be tensioned over and deformed around one or more primary containers to hold the one or more primary containers in place relative to the main panel of the body.

公开(公告)号：US11472773B2

公开(公告)日：2022-10-18

申请号：US16920144

申请日：2020-07-02

Applicant: AMGEN INC. ,  CYTOKINETICS, INC.

Inventor： Sheng Cui ,  Henry Morrison ,  Karthik Nagapudi ,  Shawn D. Walker ,  Charles Bernard ,  Karl Bennett Hansen ,  Neil Fred Langille ,  Alan Martin Allgeier ,  Steven Mennen ,  Jacqueline C. S. Woo ,  Bradley Paul Morgan ,  Alex Muci

IPC: A61P9/00 ,  A61P9/04 ,  C07D213/75 ,  A61K47/38 ,  A61K31/496 ,  A61K9/20

Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.

公开(公告)号：US20220323545A1

公开(公告)日：2022-10-13

申请号：US17640177

申请日：2020-09-02

Applicant: AMGEN INC.

Inventor： Hailing HSU

IPC: A61K38/20 ,  A61K38/57 ,  A61K45/06

Abstract: This invention provides compositions comprising a protein and an absorption enhancer, methods for treating inflammatory disorders, such as irritable bowel disease (IBD) comprising administering same, and methods for oral, intra-rectal, or other gut-related administration of a protein with an enzymatic activity, comprising orally, intra-rectally, or other gut-related administering same.

公开(公告)号：US11465969B2

公开(公告)日：2022-10-11

申请号：US17263224

申请日：2019-08-16

Applicant: AMGEN INC. ,  CYTOKINETICS, INC.

Inventor： Henry Morrison ,  Sheng Cui ,  Kyle Quasdorf ,  Evelyn Yanez ,  Bin Peter Quan ,  Ron C. Kelly ,  Sebastien Caille ,  Lingyun Xiao ,  David Pearson ,  Jaclyn Raeburn ,  Ailsa Golightly ,  Bradley Morgan ,  Matthew Peterson ,  Alex Eberlin ,  Alexander Oblezov

IPC: C07D213/75

Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.

公开(公告)号：US11464900B2

公开(公告)日：2022-10-11

申请号：US17099137

申请日：2020-11-16

Applicant: AMGEN INC.

Inventor： Adam B. McCullough ,  Erich Coiner ,  Alan D. Payne

IPC: A61M5/142

Abstract: An insertion mechanism for a drug delivery device including a trocar, a housing, and a manifold in fluid communication with a fluid pathway connector and movable relative to the housing between a first manifold position adjacent to a proximal end of the housing and a second manifold position adjacent to a distal end of the housing. A hub carrying the trocar or hollow delivery needle is removably connected to the manifold, the hub being movable relative to the housing between a first hub position adjacent to the proximal end of the housing and a second hub position adjacent to the distal end of the housing. A power source is configured to generate rotational motion. A motion conversion mechanism operatively connects the power source and the hub, and is configured to convert the rotational motion into linear motion of the hub.

公开(公告)号：US11464857B2

公开(公告)日：2022-10-11

申请号：US15902775

申请日：2018-02-22

Applicant: AMGEN INC.

Inventor： Christopher James Sloey ,  Sekhar Kanapuram ,  Huanchun Cui ,  Chio Mui Chan ,  Elaheh Binabaji

IPC: A61K39/395 ,  C07K16/40 ,  A61K47/18 ,  C07K1/36 ,  A61K9/00 ,  C07K1/16 ,  C07K16/06 ,  C07K16/22

Abstract: Provided herein are formulations of PCSK9-binding polypeptides, such as those comprising evolocumab, that comprise N-acetyl arginine and have reduced viscosities when compared to formulations lacking N-acetyl arginine. Provided herein are also methods of formulating such compositions that are advantageous in that they conserve certain components. Such formulations comprising PCSK9-binding polypeptides can be administered to patients to treat and/or prevent PCSK9-related diseases, conditions, and disorders.