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公开(公告)号:US11492372B2
公开(公告)日:2022-11-08
申请号:US17554865
申请日:2021-12-17
Applicant: AMGEN INC.
Inventor: Samuel Ray Trejo , Robert Perry Brake
IPC: B01D15/36 , B01D15/38 , C07K1/18 , C07K16/00 , C07K1/22 , C07K14/705 , C07K14/715 , B01D15/18
Abstract: The invention provides for the removal of a large fraction of contaminants from protein preparations while maintaining a high level of recovery using tentacle anion exchange matrix chromatography medium. Using the methods of the invention, leached affinity chromatography contaminants can be removed from recombinant protein preparations.
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公开(公告)号:US11192919B2
公开(公告)日:2021-12-07
申请号:US16042965
申请日:2018-07-23
Applicant: AMGEN INC.
Inventor: Samuel Ray Trejo , Robert Perry Brake
IPC: C07K1/18 , B01D15/38 , C07K16/00 , B01D15/36 , C07K14/705 , C07K14/715 , B01D15/18 , C07K1/22
Abstract: The invention provides for the removal of a large fraction of contaminants from protein preparations while maintaining a high level of recovery using tentacle anion exchange matrix chromatography medium. Using the methods of the invention, leached affinity chromatography contaminants can be removed from recombinant protein preparations.
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