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公开(公告)号：US20090234416A1
公开(公告)日：2009-09-17
申请号：US12401194
申请日：2009-03-10
申请人： John R. Zielinski , Shantha Arcot-Krishnamurthy , Joseph M. Pastore , Jeffrey E. Stahmann , Allan C. Shuros
发明人： John R. Zielinski , Shantha Arcot-Krishnamurthy , Joseph M. Pastore , Jeffrey E. Stahmann , Allan C. Shuros
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3688
摘要： This document discusses, among other things, an apparatus comprising an implantable cardiac depolarization sensing circuit, an electrical stimulation circuit, and a pacing mode controller. The pacing mode controller is configured to deliver pacing therapy according to a first pacing mode that is a normal operating mode, and to deliver pacing therapy according to second and third pacing modes. The second and third pacing modes increase mechanical stress on at least a particular portion of the ventricle as compared to the pacing therapy delivered during the first pacing mode. The pacing mode controller alternates between the second and third pacing modes when switched from the normal operating mode to a stress augmentation mode and stores a statistic related to the stress augmentation mode in a stress augmentation cycle memory area.
摘要翻译： 本文件尤其涉及包括可植入心脏去极化感测电路，电刺激电路和起搏模式控制器的装置。 起搏模式控制器被配置为根据作为正常操作模式的第一起搏模式提供起搏治疗，并且根据第二和第三起搏模式输送起搏治疗。 与在第一起搏模式期间递送的起搏治疗相比，第二和第三起搏模式增加至少在心室的特定部分上的机械应力。 当从正常操作模式切换到应力增强模式时，起搏模式控制器在第二和第三起搏模式之间交替，并将与应力增加模式相关的统计量存储在应力增加周期存储区域中。
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公开(公告)号：US20090082823A1
公开(公告)日：2009-03-26
申请号：US11903758
申请日：2007-09-25
IPC分类号： A61N1/365
CPC分类号： A61N1/3682 , A61N1/3627 , A61N1/36514 , A61N1/36535 , A61N1/36585 , A61N1/3688
摘要： An implantable pacing device for delivering ventricular pacing may be configured to intermittently and variably reduce the AV delay interval used in an atrial triggered pacing mode in a manner that simulates exercise. The device may be programmed to intermittently switch to and from a variably shortened AV delay mode according to defined entry and exit conditions.
摘要翻译： 用于递送心室起搏的可植入起搏装置可以被配置为以模拟运动的方式间歇地和可变地减小在心房触发起搏模式中使用的AV延迟间隔。 该设备可以被编程为根据定义的进入和退出条件间歇地切换到可变地缩短的AV延迟模式。
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公开(公告)号：US20080294228A1
公开(公告)日：2008-11-27
申请号：US11752377
申请日：2007-05-23
IPC分类号： A61N1/05
摘要： A device and method for controllably augmenting the flow of lymphatic fluid through one or more lymphatic vessels. The device may utilize various means of modulating the flow of lymph, including neural, mechanical and/or chemical stimulation and could be a stand-alone device or be incorporated into any cardiac, neuromodulation and/or drug delivery device.
摘要翻译： 一种用于可控地增加通过一个或多个淋巴管的淋巴液流动的装置和方法。 该装置可以利用调节淋巴液流动的各种手段，包括神经，机械和/或化学刺激，并且可以是独立装置，或并入任何心脏，神经调节和/或药物输送装置中。
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124.发明申请METHOD AND APPARATUS FOR SENSING RESPIRATORY ACTIVITIES USING SENSOR IN LYMPHATIC SYSTEM 审中-公开传感器在淋巴系统中感染呼吸活动的方法和装置公开(公告)号：US20080234556A1
公开(公告)日：2008-09-25
申请号：US11688380
申请日：2007-03-20
申请人： M. Jason Brooke , Yachuan Pu , Allan C. Shuros
发明人： M. Jason Brooke , Yachuan Pu , Allan C. Shuros
CPC分类号： A61N1/36514 , A61B5/0031 , A61B5/113 , A61B5/415 , A61B5/418 , A61N1/3601 , A61N1/36114 , A61N1/3627
摘要： A respiratory monitoring system includes an implantable lymphatic sensor configured to be placed in a lymphatic vessel, such as the thoracic duct or a vessel branching from the thoracic duct, near the diaphragm. The implantable lymphatic sensor senses a signal indicative of respiratory activities. Examples of the signal include a diaphragmatic activity signal indicative of movement of the diaphragm and a transthoracic impedance signal indicative of pulmonary volume. In one embodiment, the respiratory monitoring system is incorporated into a cardiac rhythm management system that controls cardiac therapy delivery using the signal sensed by the implantable lymphatic sensor.
摘要翻译： 呼吸监测系统包括植入式淋巴传感器，该植入式淋巴传感器被配置为放置在淋巴管中，例如胸膜导管或在隔膜附近从胸导管分支的血管。 可植入淋巴传感器感测到指示呼吸活动的信号。 信号的示例包括指示振膜的移动的膈肌活动信号和指示肺容积的经胸阻抗信号。 在一个实施例中，将呼吸监测系统并入心脏节律管理系统，其使用由可植入淋巴传感器感测到的信号来控制心脏治疗递送。
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公开(公告)号：US20080140000A1
公开(公告)日：2008-06-12
申请号：US11567907
申请日：2006-12-07
CPC分类号： A61N1/3606 , A61M25/00 , A61N1/05 , A61N1/36007 , A61N1/36135
摘要： Renal function may be modulated by an implantable device having one or more leads or catheters disposed near the kidney via the lymphatic system. In one embodiment, lymphatic drainage from the kidney is modulated to increase or decrease tubular reabsorption of salt and water. The renal function modulation therapy may be delivered in an open-loop or closed-loop fashion, with the latter dependent upon a physiological variable such as blood pressure or cardiac output.
摘要翻译： 肾功能可以由具有通过淋巴系统设置在肾附近的一个或多个引线或导管的可植入装置调节。 在一个实施方案中，来自肾脏的淋巴引流被调节以增加或减少盐和水的管状再吸收。 肾功能调节治疗可以以开环或闭环方式递送，后者取决于诸如血压或心输出量的生理变量。
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公开(公告)号：US20080114407A1
公开(公告)日：2008-05-15
申请号：US11615383
申请日：2006-12-22
IPC分类号： A61N1/05
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36564 , A61N1/3688
摘要： An implantable pacing device for delivering ventricular pacing may be configured to intermittently reduce the AVD interval for beneficial effect in patients with compromised ventricular function (e.g., HF patients and post-MI patients). The AVD interval may be reduced in an AVD reduction mode, by shortening the AVD in an atrial triggered ventricular pacing mode or by switching to a non-atrial triggered ventricular pacing mode (e.g., VVI) and delivering paces at a rate above the intrinsic rate. The physiological effects of AVD reduction may be either positive or negative on cardiac output, depending upon the individual patient.
摘要翻译： 用于输送心室起搏的可植入起搏装置可以被配置为间歇地减小AVD间隔，以在患有心室功能受损的患者（例如，HF患者和MI后患者）中产生有益效果。 通过在心房触发的心室起搏模式中缩短AVD或者通过切换到非心房触发的心室起搏模式（例如，VVI）并以高于内在速率的速率递送步进，AVD间期可以减小AVD减小模式 。 取决于个体患者，AVD减少的生理作用可能是心输出量的正或负。
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公开(公告)号：US20070282382A1
公开(公告)日：2007-12-06
申请号：US11422417
申请日：2006-06-06
申请人： Allan C. Shuros , Michael J. Kane
发明人： Allan C. Shuros , Michael J. Kane
IPC分类号： A61N1/00
CPC分类号： A61B5/03 , A61B5/0031 , A61B5/076 , A61B5/14546 , A61B5/415 , A61B5/418 , A61B5/4839 , A61N1/3627 , A61N1/36514
摘要： A device and method are disclosed for physiological monitoring of the lymphatic system. An implantable device is configured with a lymphatic sensor disposed in a lymphatic vessel for sensing pressure, flow, and/or the concentration of particular markers within the vessel. The device may be further configured to deliver appropriate therapy in accordance with the lymphatic monitoring.
摘要翻译： 公开了用于淋巴系统的生理监测的装置和方法。 可植入装置配置有设置在淋巴管中的淋巴传感器，用于感测容器内的特定标记物的压力，流量和/或浓度。 该装置还可以被配置成根据淋巴监测进行适当的治疗。
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128.发明申请公开(公告)号：US20070282380A1
公开(公告)日：2007-12-06
申请号：US11675696
申请日：2007-02-16
申请人： M. Jason Brooke , Allan C. Shuros
发明人： M. Jason Brooke , Allan C. Shuros
IPC分类号： A61N1/05
CPC分类号： A61N1/362 , A61B5/0031 , A61B5/0452 , A61B5/415 , A61B5/418 , A61M2202/0405 , A61N1/0504
摘要： A technique utilizing an endolymphatically implanted lead having one or more electrodes that may be used for sensing cardiac activity and/or delivering cardiac electrical stimulation by an implantable cardiac device. An electrode disposed in the thoracic duct is in close proximity to the left ventricle and generates an electrogram especially suitable for ischemia detection and/or discriminating between ventricular tachycardias and supraventricular tachycardias.
摘要翻译： 一种利用可以用于感测心脏活动和/或通过可植入心脏装置递送心脏电刺激的一个或多个电极的内淋巴注入导联的技术。 设置在胸导管中的电极紧邻左心室，并且产生特别适用于心室心动过速和室上性心动过速之间缺血检测和/或辨别的电描记图。
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129.发明申请公开(公告)号：US20070282376A1
公开(公告)日：2007-12-06
申请号：US11422421
申请日：2006-06-06
IPC分类号： A61N1/32
CPC分类号： A61N1/36114
摘要： An implantable neural stimulation system includes an implantable medical device having a neural stimulation circuit and at least one implantable lead configured to allow one or more stimulation electrodes to be placed in one or more lymphatic vessels of a patient, such as the patient's thoracic duct and/or vessels branching from the thoracic duct. Neural stimulation pulses are delivered from the implantable medical device to one or more target regions adjacent to the thoracic duct or the vessels branching from the thoracic duct through the one or more stimulation electrodes.
摘要翻译： 可植入神经刺激系统包括具有神经刺激电路的可植入医疗装置和至少一个可植入引线，其被配置为允许将一个或多个刺激电极放置在患者的一个或多个淋巴管中，例如患者的胸导管和/ 或从胸导管分支的血管。 神经刺激脉冲从可植入医疗装置传送到与胸导管相邻的一个或多个目标区域或通过一个或多个刺激电极从胸导管分支的血管。
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公开(公告)号：US09192790B2
公开(公告)日：2015-11-24
申请号：US13086116
申请日：2011-04-13
CPC分类号： A61N7/022 , A61B8/0891 , A61B8/12 , A61B8/4488 , A61B18/0206 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2090/3784 , A61N2007/003 , A61N2007/0095
摘要： Acoustic energy is delivered to innervated vascular that contributes to renal sympathetic nerve activity, such as innervated tissue of the renal artery and abdominal aorta. Focused acoustic energy is delivered via an intravascular device of sufficient power to ablate innervated renal or aortal tissue. Focused acoustic energy may be delivered via an intravascular or extracorporeal device to image and locate target innervated renal or aortal tissue. Intravascular, extravascular, or transvascular focused ultrasound devices provide for high precision denervation of innervated vascular to terminate renal sympathetic nerve activity.
摘要翻译： 声能传递给有助于肾交感神经活动的神经支配的血管，如肾动脉和腹主动脉的神经支配组织。 聚焦的声能通过具有足够功率的血管内装置递送以消融支配的肾脏或主动脉组织。 聚焦的声能可以通过血管内或体外装置递送到图像并定位目标神经支配的肾或主动脉组织。 血管内，血管外或经血管聚焦的超声装置提供神经支配血管的高精度去神经支配以终止肾交感神经活动。
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