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    METHOD FOR CAUSING STOCHASTIC POLARIZATION IN THE SPINAL CORD TO INHIBIT TRANSMISSION OF SYNCHRONOUS ACTION POTENTIALS
    105.
    发明申请
    METHOD FOR CAUSING STOCHASTIC POLARIZATION IN THE SPINAL CORD TO INHIBIT TRANSMISSION OF SYNCHRONOUS ACTION POTENTIALS 有权
    引起脊髓中的狭窄偏振以抑制同步动作电位传递的方法

    公开(公告)号：US20170028201A1

    公开(公告)日：2017-02-02

    申请号：US15191214

    申请日：2016-06-23

    Applicant: University of Iowa Research Foundation

    Inventor： Matthew A. Howard

    IPC: A61N1/36 ,  A61N1/06 ,  A61N1/05 ,  A61N1/372

    CPC classification number: A61N1/36071 ,  A61N1/0553 ,  A61N1/0558 ,  A61N1/06 ,  A61N1/36067 ,  A61N1/36103 ,  A61N1/36114 ,  A61N1/36139 ,  A61N1/36171 ,  A61N1/37223

    Abstract: This invention provides a new technology for management of back pain by stimulating the spinal cord in a manner that renders it refractory to transmission of deleterious or undesirable sensory input. The electrical stimulus comprises high frequency pulses in a regular or complex pattern or that are stochastically produced under microprocessor control. The stimulus is applied directly to the surface of the spinal cord from within the spinal canal, which provides important benefits over previous technology. The stimulus alleviates symptoms and signs of back pain, while minimizing the risk of side effects such as paresthesia, and potentially minimizing the effects on motor neuron transmission and proprioception.

    Abstract translation: 本发明提供了一种用于通过以使得其难以传播有害或不期望的感觉输入的方式刺激脊髓来管理背部疼痛的新技术。 电刺激包括规则或复杂图案的高频脉冲或者在微处理器控制下随机产生的。 刺激从椎管内直接施加到脊髓表面，这比以前的技术提供了重要的益处。 刺激减轻背部疼痛的症状和体征，同时尽量减少副作用（如感觉异常）的风险，并可能最小化对运动神经元传播和本体感觉的影响。

    System and related method to restore and/or improve nervous system functions by modifying specific nervous system pathways
    106.
    发明授权
    System and related method to restore and/or improve nervous system functions by modifying specific nervous system pathways 有权
    系统和相关方法通过修改特定的神经系统途径来恢复和/或改善神经系统功能

    公开(公告)号：US09545515B2

    公开(公告)日：2017-01-17

    申请号：US14855879

    申请日：2015-09-16

    Applicant: Health Research, Inc.

    Inventor： Jonathan R. Wolpaw ,  Gerwin Schalk ,  Aiko K. Thompson ,  Peter Brunner ,  Xiang Yang Chen ,  Dennis J. McFarland

    IPC: A61N1/00 ,  A61N1/36 ,  A61B5/0488 ,  A61N1/04 ,  A61B5/0492 ,  A61B5/00

    CPC classification number: A61N1/36014 ,  A61B5/0488 ,  A61B5/0492 ,  A61B5/4848 ,  A61B5/6828 ,  A61B5/742 ,  A61B2562/046 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/36003 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/36103

    Abstract: The present invention provides methods, devices, and systems for restoring or improving nervous system function of a subject. Provided is a method involving: (i) providing an operant conditioning protocol effective to produce targeted neural plasticity (TNP) in a primary targeted central nervous system (CNS) pathway of a subject; and (ii) administering the operant conditioning protocol to the subject to elicit TNP in the primary targeted CNS pathway and to elicit generalized neural plasticity (GNP) in one or more other CNS pathway. The elicitation of the GNP in the one or more other CNS pathway serves to restore or improve a nervous system function of the subject. Provided is a device comprising a nerve stimulation-electromyographic recording component and a controller for operating the nerve stimulation-electromyographic recording component in accordance with an operant conditioning protocol.

    Abstract translation: 本发明提供了用于恢复或改善受试者的神经系统功能的方法，装置和系统。 提供了一种方法，其包括：（i）提供有效地在受试者的主要靶向中枢神经系统（CNS）途径中产生靶向神经可塑性（TNP）的操作调节方案; 和（ii）向受试者施用操作调节方案以在主要靶向CNS途径中引发TNP，并在一个或多个其它CNS途径中引发广义神经可塑性（GNP）。 在一种或多种其他CNS途径中引发GNP用于恢复或改善受试者的神经系统功能。 提供了包括神经刺激 - 肌电记录部件和根据操作调节方案来操作神经刺激 - 肌电图记录部件的控制器的装置。

    SYSTEMS AND METHODS FOR MONITORING CHARGE DENSITY OF ELECTRICAL STIMULATION
    107.
    发明申请
    SYSTEMS AND METHODS FOR MONITORING CHARGE DENSITY OF ELECTRICAL STIMULATION 有权
    用于监测电刺激电荷密度的系统和方法

    公开(公告)号：US20160303379A1

    公开(公告)日：2016-10-20

    申请号：US14687773

    申请日：2015-04-15

    Applicant: PACESETTER, INC.

    Inventor： Lanitia Ness ,  Martin Cholette

    IPC: A61N1/36

    CPC classification number: A61N1/0534 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/36 ,  A61N1/3606 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/36142 ,  A61N1/36146 ,  A61N1/3686 ,  A61N2001/083

    Abstract: The present disclosure provides neurostimulation systems and methods. A neurostimulation system includes at least one anode, at least one cathode, the at least one anode and the at least one cathode configured to apply electrical stimulation to a patient, and a controller electrically coupled to the at least one anode and the at least one cathode, the controller configured to determine when one of the at least one anode and the at least one cathode fails, measure, in response to the determination, a quantity indicative of a charge density of the applied electrical stimulation, compare the measured quantity to a predetermined limit, and perform at least one action when the measured quantity exceeds the predetermined limit.

    Abstract translation: 本公开提供神经刺激系统和方法。 神经刺激系统包括至少一个阳极，至少一个阴极，所述至少一个阳极和至少一个阴极，被配置为对患者施加电刺激，以及控制器，电耦合到所述至少一个阳极和所述至少一个阳极 阴极，所述控制器被配置为确定所述至少一个阳极和所述至少一个阴极中的一个何时出现故障，响应于所述确定测量指示所施加的电刺激的电荷密度的量，将所测量的量与 并且当所测量的量超过预定极限时执行至少一个动作。

    Managing back pain by applying a high frequency electrical stimulus directly to the spinal cord
    109.
    发明授权
    Managing back pain by applying a high frequency electrical stimulus directly to the spinal cord 有权
    通过将高频电刺激直接应用于脊髓来治疗腰痛

    公开(公告)号：US09403008B2

    公开(公告)日：2016-08-02

    申请号：US14375785

    申请日：2013-01-30

    Applicant: University of Iowa Research Foundation

    Inventor： Matthew A. Howard

    IPC: A61N1/32 ,  A61N1/34 ,  A61N1/36 ,  A61N1/05 ,  A61N1/06 ,  A61N1/372

    CPC classification number: A61N1/36071 ,  A61N1/0553 ,  A61N1/0558 ,  A61N1/06 ,  A61N1/36067 ,  A61N1/36103 ,  A61N1/36114 ,  A61N1/36139 ,  A61N1/36171 ,  A61N1/37223

    Abstract: This invention provides a new technology for management of back pain by stimulating the spinal cord in a manner that renders it refractory to transmission of deleterious or undesirable sensory input. The electrical stimulus comprises high frequency pulses in a regular or complex pattern or that are stochastically produced under microprocessor control. The stimulus is applied directly to the surface of the spinal cord from within the spinal canal, which provides important benefits over previous technology. The stimulus alleviates symptoms and signs of back pain, while minimizing the risk of side effects such as paresthesia, and potentially minimizing the effects on motor neuron transmission and proprioception.

    Abstract translation: 本发明提供了一种用于通过以使得其难以传播有害或不期望的感觉输入的方式刺激脊髓来管理背部疼痛的新技术。 电刺激包括规则或复杂图案的高频脉冲或者在微处理器控制下随机产生的。 刺激从椎管内直接施加到脊髓表面，这比以前的技术提供了重要的益处。 刺激减轻背部疼痛的症状和体征，同时尽量减少副作用（如感觉异常）的风险，并可能最小化对运动神经元传播和本体感觉的影响。

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