公开(公告)号：US20240123264A1

公开(公告)日：2024-04-18

申请号：US18398565

申请日：2023-12-28

Applicant: Profound Medical Inc.

Inventor： Mathieu Allard

IPC: A61N7/00

CPC classification number: A61N7/00 ,  A61N2007/0004 ,  A61N2007/0043 ,  A61N2007/0052 ,  A61N2007/0078 ,  A61N2007/0086

Abstract: A method for delivering ultrasound therapy using open-loop controls comprises inserting a distal tip of a therapeutic ultrasound applicator into a patient's urethra, the distal tip including an ultrasound transducer; acquiring ultrasound images of the patient's urethra and prostate with an ultrasound imaging probe; aligning the distal tip of the therapeutic ultrasound applicator with the patient's prostate using the ultrasound images; delivering therapeutic ultrasound energy to the patient's prostate, with the ultrasound transducer, according to a treatment plan, the treatment plan including a predetermined limited angular range for the therapeutic ultrasound energy that avoids the patient's rectum and neurovascular bundles, wherein the therapeutic ultrasound is delivered without temperature feedback data.

公开(公告)号：US20240075321A1

公开(公告)日：2024-03-07

申请号：US18261830

申请日：2022-12-02

Applicant: IMGT CO., LTD.

Inventor： Keon Ho SON ,  Dae Seung KIM

IPC: A61N7/02 ,  A61B8/00 ,  A61B8/08

CPC classification number: A61N7/02 ,  A61B8/0808 ,  A61B8/4209 ,  A61B8/4416 ,  A61B8/4461 ,  A61B8/4488 ,  A61N2007/0052

Abstract: Disclosed are an ultrasound imaging apparatus for brain disease treatment and an ultrasound imaging and treatment method using same. The ultrasound imaging apparatus for brain disease treatment according to an embodiment includes an image obtainment unit which obtains a medical image of the brain of a patient captured before a procedure; a transducer unit which transmits an ultrasound signal for imaging and ultrasound focusing of the brain of the patient; an image generation unit which generates an ultrasound image on the basis of the ultrasound signal received from the brain; a position alignment unit which controls a position of the transducer unit to align a position of the generated ultrasound image with a position of the obtained medical image; an image matching unit which matches two images of which positions are aligned; and an image display unit which detects and displays a brain lesion by using a matched image.

公开(公告)号：US11896853B2

公开(公告)日：2024-02-13

申请号：US16871980

申请日：2020-05-11

Applicant: University of Washington

Inventor： Vera Khokhlova ,  Pavel Rosnitskiy ,  Petr V. Yuldashev ,  Tatiana D. Khokhlova ,  Oleg A. Sapozhnikov ,  George R. Schade

IPC: A61N7/02 ,  A61B8/12 ,  A61B8/00 ,  A61B17/32 ,  A61B17/00 ,  A61N7/00

CPC classification number: A61N7/022 ,  A61B8/12 ,  A61B8/445 ,  A61B2017/00274 ,  A61B2017/320069 ,  A61N2007/0039 ,  A61N2007/0052 ,  A61N2007/0078

Abstract: Transrectal ultrasound probe for boiling histotripsy ablation of prostate are presented herein. In one embodiment, a method for a transrectal ultrasound treatment uses high intensity focused ultrasound (HIFU). The method includes: generating a boiling histotripsy (BH) therapy ultrasound by a therapy transducer in a frequency range of 1 MHz to 2.8 MHz and a surface intensity range of 10 W/cm2 to 80 W/cm2. The therapy transducer may be about 50 mm long and about 35 mm wide. The method also includes applying the therapy ultrasound by directing ultrasound pulses having ultrasound shock waves to a target tissue at a focal depth of 2.5 cm to 5.5 cm; generating at least one μm-scale vapor bubble at a target region; growing the at least one vapor bubble to at least one mm-scale bubble; and mechanically disintegrating a surrounding tissue by interactions between mm-scale bubbles and the ultrasound shock waves within a pulse.

公开(公告)号：US20240009486A1

公开(公告)日：2024-01-11

申请号：US17858325

申请日：2022-07-06

Applicant: X Development LLC

Inventor： Vladimir Miskovic ,  Ningrui Li ,  Joel Emilio Bregman Segre

IPC: A61N7/00 ,  A61B8/06 ,  A61B8/08 ,  A61B8/00 ,  G01S15/89 ,  G01S7/52

CPC classification number: A61N7/00 ,  A61B8/06 ,  A61B8/485 ,  A61B8/4488 ,  A61B8/54 ,  G01S15/8913 ,  G01S15/892 ,  G01S7/5202 ,  A61N2007/0026 ,  A61N2007/0052 ,  A61N2007/0095

Abstract: A system includes: an ultrasound array comprising a first subset of transducer elements are configured to emit ultrasound pulses through the subject's skull for performing a neuro-modulation of the subject's brain during use of the system, and a second subset of transducer elements configured to receive ultrasound signals from the subject's skull and brain in response to the ultrasound pulses being emitted from the first subset of transducer elements; and a controller coupled to the ultrasound array, wherein the controller is configured, during use of the system, to: detect a change of a physiological parameter in at least a portion of the subject's brain based on, at least in part, the ultrasound signals received by the second subset of transducer elements, and determine a dose of the neuro-modulation of the subject's brain based on, at least in part, the detected change of the physiological parameter.

公开(公告)号：US11857807B2

公开(公告)日：2024-01-02

申请号：US16622050

申请日：2018-06-29

Applicant: Yoav Levy ,  Rafi De Picciotto ,  Javier Grinfeld ,  Eyal Zadicario

Inventor： Yoav Levy ,  Rafi De Picciotto ,  Javier Grinfeld ,  Eyal Zadicario

IPC: A61M37/00 ,  A61N7/00 ,  A61N5/10 ,  A61B5/00 ,  A61N7/02 ,  A61B34/10 ,  A61B6/12 ,  A61B6/03 ,  A61B6/00

CPC classification number: A61N5/1049 ,  A61B5/489 ,  A61B34/10 ,  A61M37/0092 ,  A61N5/103 ,  A61N5/1039 ,  A61N5/1048 ,  A61N5/1064 ,  A61N7/02 ,  A61B5/4836 ,  A61B6/03 ,  A61B6/12 ,  A61B6/504 ,  A61N2005/1052 ,  A61N2005/1055 ,  A61N2005/1058 ,  A61N2005/1061 ,  A61N2005/1087 ,  A61N2005/1092 ,  A61N2005/1098 ,  A61N2007/0004 ,  A61N2007/0039 ,  A61N2007/0052 ,  A61N2007/0082 ,  A61N2007/027

Abstract: Various approaches for computationally generating a protocol for treatment of one or more target BBB regions within a tissue region of interest using a source of focused ultrasound include specifying (i) settings of sonication parameters for applying one or more sequence of sonications to the target BBB region using the source of focused ultrasound and (ii) a characteristic of microbubbles selected to be administered into the target BBB region; electronically simulating treatment in accordance with the protocol at least in part by computationally executing the sequence(s) of sonications and computationally administering the microbubbles having the characteristic; and computationally predicting a tissue disruption effect of the target BBB region resulting from the treatment.

公开(公告)号：US20230264049A1

公开(公告)日：2023-08-24

申请号：US18015256

申请日：2021-07-12

Applicant: SecondWave Systems, Inc.

Inventor： Daniel P. ZACHS ,  Anuj BHARDWAJ ,  Jeffrey HEYMAN ,  Kashyap PATEL ,  Claire KAISER ,  John BASILE ,  Hubert Hyoungil LIM ,  Gerardo Rodriguez ORELLANA

IPC: A61N7/00 ,  A61B8/08 ,  A61B8/00

CPC classification number: A61N7/00 ,  A61B8/085 ,  A61B8/4427 ,  A61B8/485 ,  A61N2007/0004 ,  A61N2007/0052

Abstract: A method for directing ultrasound energy toward an organ of a subject, including: determining a location of the organ within the subject's body; and directing ultrasound energy at the location of the organ within the subject's body using a wearable ultrasound device.

公开(公告)号：US20230191162A1

公开(公告)日：2023-06-22

申请号：US18167602

申请日：2023-02-10

Applicant: Sunnybrook Research Institute ,  Vitreosonic Inc.

Inventor： Gary Lloyd Ka Tao Yau ,  Kullervo Henrik Hynynen

IPC: A61N7/02

CPC classification number: A61N7/02 ,  A61N2007/0052

Abstract: In at least some examples, a method of treating an eye, includes (i) imaging a patient's vitreous using a probe, (ii) defining a window on a desired region of the vitreous, (iii) administering ultrasonic energy treatment to the desired region within the window, (iv) continually monitoring the treatment via the probe, (v) adjusting a characteristic of the ultrasonic energy treatment based on the monitoring, (vi) re-imaging the desired region of the vitreous after the treatment is administered, and (vii) evaluating or observing the desired region to determine whether a target percentage of a vitreous opacity has been resolved.

公开(公告)号：US11648424B2

公开(公告)日：2023-05-16

申请号：US16930181

申请日：2020-07-15

Applicant: HISTOSONICS, INC.

Inventor： Jonathan M. Cannata ,  Ryan Miller ,  Alexander P. Duryea ,  Dejan Teofilovic ,  Zeljko Mladenovic ,  Aleksandra Rakic ,  Joshua Stopek

IPC: A61N7/00 ,  A61B8/08 ,  A61B17/22

CPC classification number: A61N7/00 ,  A61B8/085 ,  A61B2017/22008 ,  A61N2007/0039 ,  A61N2007/0052

Abstract: A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening/non-target tissues or structures.

公开(公告)号：US20190232090A1

公开(公告)日：2019-08-01

申请号：US16246522

申请日：2017-07-13

Applicant: Shmuel BEN-EZRA

Inventor： Shmuel BEN-EZRA

IPC: A61N7/02 ,  A61B8/08

CPC classification number: A61N7/02 ,  A61B8/485 ,  A61B8/488 ,  A61N2007/0052 ,  A61N2007/0073 ,  A61N2007/0095

Abstract: Apparatus is provided for assessing a characteristic of a first acoustic field (22) at a first frequency in a region (24) of a medium (26), the first acoustic field generating oscillatory motion of scatterers (28) disposed within the medium, at the first frequency. An acoustic transducer (30) (a) generates a second acoustic field (32) at a second frequency in the region, the second frequency being higher than the first frequency, and (b) receives echo data of the second acoustic field scattering off the oscillating scatterers in the medium, the echo data containing Doppler-shifted frequencies related to the oscillations of the scatterers, resulting in a time-dependent Doppler shift that oscillates at a frequency that is related to the first frequency. Control circuitry (36) (a) extracts the oscillating time-dependent Doppler shift from the received echo data, and (b) converts the extracted Doppler shift into particle-velocity of the first acoustic field.

公开(公告)号：US20190192112A1

公开(公告)日：2019-06-27

申请号：US16042294

申请日：2018-07-23

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Elisa E. Konofagou ,  Tobias Teichert ,  Vincent P. Ferrera ,  Fabrice Marquet ,  Yao-Sheng Tung ,  Shih-Ying Wu

IPC: A61B8/08 ,  A61N7/02 ,  A61B8/00

CPC classification number: A61B8/0808 ,  A61B8/4281 ,  A61B8/481 ,  A61B8/5223 ,  A61B2090/378 ,  A61N7/02 ,  A61N2007/0039 ,  A61N2007/0052 ,  A61N2007/0091

Abstract: Systems and techniques for real-time, transcranial monitoring of safe blood-brain barrier opening include determining an approach angle for targeted blood-brain barrier opening proximate a predetermined region in a brain of a patient, and positioning an ultrasound transducer to generate a focused ultrasound signal at the determined approach angle to the predetermined region in the brain.