公开(公告)号：USD814019S1

公开(公告)日：2018-03-27

申请号：US29577425

申请日：2016-09-13

申请人： Glaxo Group Limited

设计人： Gary Thomas Crosby ,  John Deamer ,  Philip William Farr ,  Stephen Maurice Pitson ,  Alan Anthony Wilson

公开(公告)号：US20170349571A1

公开(公告)日：2017-12-07

申请号：US15616578

申请日：2017-06-07

申请人： Vanderbilt University ,  Glaxo Group Limited

发明人： Roger D. Cone ,  Michael J. Bishop ,  Eugene L. Stewart ,  Lawrence A. Wolfe ,  Jaques Pantel ,  Julien Sebag ,  C. David Weaver ,  Savannah Williams ,  Helen Cox ,  Ian Tough ,  Luis Diaz Gimenez ,  Subramanian Baskaran

IPC分类号： C07D401/12 ,  A61K38/34 ,  A61K31/454 ,  A61K45/06 ,  A61K31/4439

CPC分类号： C07D401/12 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K38/34 ,  A61K45/06 ,  A61K2300/00

摘要： Disclosed herein are positive allosteric modulators of melanocortin receptor and methods of using such modulators.

公开(公告)号：US09833449B2

公开(公告)日：2017-12-05

申请号：US15352340

申请日：2016-11-15

申请人： Glaxo Group Limited

发明人： Stephen John Atkinson ,  Michael David Barker ,  Matthew Campbell ,  Hawa Diallo ,  Clement Douault ,  Neil Stuart Garton ,  John Liddle ,  Robert John Sheppard ,  Ann Louise Walker ,  Christopher Wellaway ,  David Matthew Wilson

IPC分类号： A61K31/4184 ,  C07D471/04 ,  A61K31/4545

CPC分类号： A61K31/4545 ,  A61K31/407 ,  A61K31/4184 ,  C07D471/04

摘要： Compounds of formula (I): wherein; R1 is hydrogen or C1-6alkyl; R2 is hydrogen, C1-6alkyl, perhalomethylC0-5alkyl-O—, or C1-6alkoxy; R3 is hydrogen, C1-6alkyl, or C1-6alkoxyC1-6alkyl; R4 is hydrogen, C1-6alkyl, perhalomethylC1-6alkyl; or unsubstituted C3-6cycloalkylC1-6alkyl; A is C—R5 or N; B is C—R6 or N; D is C—R7 or N; with the proviso that at least one of A, B, and D, is N; R5 is hydrogen or C1-6alkyl; R6 is hydrogen or C1-6alkyl; R7 is hydrogen, C1-6alkyl, C1-6alkoxy, or hydroxy; R8 is hydrogen or C1-6alkyl, with the proviso that one of R4 and R8 is hydrogen; R9 is hydrogen or hydroxy; R10 is hydrogen or C1-6alkyl; and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.

公开(公告)号：US20170281532A1

公开(公告)日：2017-10-05

申请号：US15490220

申请日：2017-04-18

申请人： Glaxo Group Limited ,  Shionogi and Co., Ltd

发明人： Toshiaki AOKI ,  Hiroki KUSANO ,  Xiangmin LIAO ,  Neil David PEARSON ,  Israil PENDRAK ,  Jun SATO ,  Reema K. THALJI ,  Kenji YAMAWAKI ,  Katsuki YOKOO

IPC分类号： C07D501/48 ,  C07D501/50 ,  C07D505/24 ,  A61K9/00

CPC分类号： C07D501/48 ,  A61K9/0019 ,  C07D501/50 ,  C07D505/24 ,  Y02A50/473

摘要： The compounds of the subject invention are related to 2-substituted cephem compounds, which have a wide antimicrobial spectrum, in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and pharmaceutical compositions comprising the same.

公开(公告)号：US09725420B2

公开(公告)日：2017-08-08

申请号：US15235468

申请日：2016-08-12

申请人： Glaxo Group Limited

发明人： Kevin Stuart Cardwell ,  Claire Frances Crawford ,  Suzanne Helen Davies ,  Charles Edward Wade

IPC分类号： C07D239/70 ,  C07C227/08 ,  C07C229/16

CPC分类号： C07D239/70 ,  C07C227/08 ,  C07C229/16

摘要： This invention relates to methods of making a compound of formula (I) and intermediates for same the compounds of formula (I) being useful for treating cardiovascular and inflammatory diseases such as atherosclerosis.

公开(公告)号：US09694004B2

公开(公告)日：2017-07-04

申请号：US15254160

申请日：2016-09-01

申请人： Glaxo Group Limited

发明人： Mei-yin Lee

IPC分类号： A61K31/4709 ,  C07D401/12

CPC分类号： A61K31/4709 ,  C07B2200/13 ,  C07D401/12

摘要： A novel crystalline form of a compound is disclosed.

公开(公告)号：US09682999B2

公开(公告)日：2017-06-20

申请号：US14548524

申请日：2014-11-20

申请人： Glaxo Group Limited

发明人： Pek Yoke Chong ,  John F. Miller ,  Andrew James Peat ,  John Brad Shotwell

IPC分类号： A61K31/34 ,  A61K31/343 ,  A61K31/69 ,  C07F5/02 ,  A61K45/06 ,  C07F5/04 ,  C07D307/85

CPC分类号： C07F5/025 ,  A61K31/34 ,  A61K31/343 ,  A61K31/69 ,  A61K45/06 ,  C07D307/85 ,  C07F5/027 ,  C07F5/04

摘要： The present invention features compounds of formula (I): and salts thereof, pharmaceutical compositions comprising said compounds, and uses of such compounds in treating or preventing viral infections, such as HCV infections, and diseases associated with such infections.

公开(公告)号：US20170152312A1

公开(公告)日：2017-06-01

申请号：US15428528

申请日：2017-02-09

申请人： GLAXO GROUP LIMITED

发明人： Gary Peter BEMBRIDGE ,  Chun-wa Chung ,  Susannah Karen FORD ,  Ian KIRBY ,  Ruth MCADAM ,  Maria FEENEY

IPC分类号： C07K16/24

摘要： The present invention concerns antigen binding proteins and fragments thereof which specifically bind Oncostatin M (OSM), particularly human OSM (hOSM) and which inhibit the binding of OSM to the gp130 receptor but does not directly interact with site II residues. The invention also concerns a method of humanising antibodies. Further disclosed are pharmaceutical compositions, screening and medical treatment methods.

公开(公告)号：US09605063B2

公开(公告)日：2017-03-28

申请号：US14540247

申请日：2014-11-13

申请人： GLAXO GROUP LIMITED

发明人： Gary Peter Bembridge ,  Chun-wa Chung ,  Susannah Karen Ford ,  Ian Kirby ,  Ruth McAdam ,  Maria Feeney

IPC分类号： A61K39/395 ,  A61K39/00 ,  C07K16/24

CPC分类号： C07K16/248 ,  C07K16/24 ,  C07K16/244 ,  C07K2317/10 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/569 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention concerns antigen binding proteins and fragments thereof which specifically bind Oncostatin M (OSM), particularly human OSM (hOSM) and which inhibit the binding of OSM to the gp130 receptor but does not directly interact with site II residues. The invention also concerns a method of humanizing antibodies. Further disclosed are pharmaceutical compositions, screening and medical treatment methods.

公开(公告)号：US09540318B2

公开(公告)日：2017-01-10

申请号：US14819836

申请日：2015-08-06

申请人： Glaxo Group Limited

发明人： Véronique Birault ,  Amanda Jennifer Campbell ,  Stephen Harrison ,  Joelle Le

IPC分类号： C07D215/02 ,  C07D215/58 ,  C07C311/44 ,  C07C311/21 ,  C07C311/29 ,  C07D213/30 ,  C07D213/38 ,  C07D213/61 ,  C07D213/65 ,  C07D213/68 ,  C07D213/75 ,  C07D233/22 ,  C07D239/28 ,  C07D249/08 ,  C07D257/04 ,  C07D261/08 ,  C07D213/42 ,  C07D231/12 ,  C07D233/64 ,  C07D239/26 ,  C07D239/34 ,  C07D213/73

CPC分类号： C07C311/44 ,  C07C311/21 ,  C07C311/29 ,  C07C2101/16 ,  C07C2601/16 ,  C07D213/30 ,  C07D213/38 ,  C07D213/42 ,  C07D213/61 ,  C07D213/65 ,  C07D213/68 ,  C07D213/73 ,  C07D213/75 ,  C07D231/12 ,  C07D233/22 ,  C07D233/64 ,  C07D239/26 ,  C07D239/28 ,  C07D239/34 ,  C07D249/08 ,  C07D257/04 ,  C07D261/08

摘要： The present invention is directed to novel retinoid-related orphan receptor gamma (RORγ) modulators, processes for their preparation, pharmaceutical compositions containing these modulators, and their use in the treatment of inflammatory, metabolic and autoimmune diseases mediated by RORγ.

摘要翻译： 本发明涉及新型维甲酸相关孤儿受体γ（RORγ）调节剂，其制备方法，含有这些调节剂的药物组合物及其在治疗由RORγ介导的炎症，代谢和自身免疫疾病中的用途。