公开(公告)号：US20210056697A1

公开(公告)日：2021-02-25

申请号：US16978489

申请日：2019-03-11

申请人： EMORY UNIVERSITY

发明人： Habib SAMADY ,  Alessandro VENEZIANI ,  Don GIDDENS ,  David MOLONY ,  Adrien LEFIEUX ,  Arnav KUMAR

IPC分类号： G06T7/00 ,  G06T7/11 ,  G16H50/30 ,  G16H30/40

摘要： The systems and methods can accurately and efficiently determine a myocardial risk from a lesion disposed along a coronary segment using hemodynamic characteristic(s) associated with one or more sections of the corresponding lesion site. The method may include segmenting one or more lesion sites disposed along at least one arterial segment of the one or more arterial segments of the coronary model into one or more sections. Each lesion site includes a lesion. The method may include determining one or more characteristics for at least one section using at least the one or more characteristics associated with the at least one arterial segment. The one or more characteristics for the at least one section including hemodynamic force characteristic(s) (e.g., wall shear stress (WSS)). The method may include determining one or more risk indices for each lesion site using at least the hemodynamic force characteristic(s) for the at least one section.

公开(公告)号：US10905586B2

公开(公告)日：2021-02-02

申请号：US16826443

申请日：2020-03-23

申请人： Emory University ,  Georgia Tech Research Corporation

发明人： Mark Prausnitz ,  Henry F. Edelhauser ,  Samirkumar Rajnikant Patel

IPC分类号： A61F9/00 ,  A61M37/00

摘要： Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye.

公开(公告)号：US10900069B2

公开(公告)日：2021-01-26

申请号：US15456024

申请日：2017-03-10

申请人： Emory University

发明人： Khalid Salaita ,  Pui-yan Ma

IPC分类号： C12P19/34 ,  C12Q1/6816 ,  C12Q1/6848 ,  C12Q1/6809 ,  C12Q1/6844 ,  C12Q1/28 ,  G01N33/542

摘要： This disclosure related to methods of detecting mechanical forces required to separate ligand and receptor interactions. In certain embodiments, this disclosure relates to methods of detecting mechanical forces between a ligand and receptor, where the ligand is immobilized on a surface using weaker forces. Ligand-receptor forces lead to dissociation of the ligand that can be detected and amplified. In certain embodiments, the disclosure relates to methods of detecting ligand and receptor interactions comprising linking a ligand to one of two binding partners, wherein the binding partners have attracting forces that are less than the forces between the ligand and a receptor of the ligand such that when the ligand binds the receptor, the binding partners will separate. Separation of the binding partners can be detected.

公开(公告)号：US20210008150A1

公开(公告)日：2021-01-14

申请号：US16894407

申请日：2020-06-05

申请人： Emory University

发明人： Raymond F. Schinazi ,  Keivan Zandi ,  Franck Amblard

IPC分类号： A61K38/06 ,  A61K38/05 ,  A61K45/06 ,  A61K31/675 ,  A61K31/53 ,  A61K31/7072 ,  A61K31/519 ,  C07K5/093 ,  C07K5/087 ,  C07K5/08 ,  C07K5/065

摘要： Compounds, compositions and methods for preventing, treating or curing a coronavirus, picornavirus, and/or hepeviridae virus infection in human subjects or other animal hosts. Specific viruses that can be treated include enteroviruses. In one embodiment, the compounds can be used to treat an infection with a severe acute respiratory syndrome virus, such as human coronavirus 229E, SARS, MERS, SARS-CoV-1 (OC43), and SARS-CoV-2. In another embodiment, the methods are used to treat a patient co-infected with two or more of these viruses, or a combination of one or more of these viruses and norovirus.

公开(公告)号：US20210008038A1

公开(公告)日：2021-01-14

申请号：US16790035

申请日：2020-02-13

申请人： Above and Beyond NB, LLC ,  Emory University

发明人： Alexandre Betourne ,  Nicholas M. Boulis ,  Raymond T. Bartus

IPC分类号： A61K31/428 ,  A61K9/00 ,  A61K9/08 ,  A61K47/40

摘要： The present invention provides methods for parenterally administering riluzole to subjects in need of treatment.

公开(公告)号：US20200318045A1

公开(公告)日：2020-10-08

申请号：US16755915

申请日：2018-10-19

申请人： Georgia Tech Research Corporation ,  Emory University

发明人： Emily Jackson-Holmes ,  Hang Lu ,  Zhexing Wen

IPC分类号： C12M1/00 ,  B01L3/00

摘要： Mesofluidic devices for culturing cell aggregates and methods of using the same are disclosed. An exemplary mesofluidic device comprises at least one fluid inlet, at least one fluid outlet, a plurality of fluid channels, and a plurality of culture chambers. Each culture chamber can comprise at least one chamber inlet and at least one chamber outlet. The at least one chamber inlet can be in fluid communication with the at least one fluid inlet via at least one of the plurality of fluid channels. The at least one chamber outlet can be in fluid communication with the at least one fluid outlet via at least one of the plurality of fluid channels The mesofluidic device can be configured to contain a cell aggregate in each of the plurality of culture chambers.

公开(公告)号：US10792274B2

公开(公告)日：2020-10-06

申请号：US16386763

申请日：2019-04-17

申请人： Emory University ,  The United States Government as Represented by the Department of Veterans Affairs

发明人： Jing Chen ,  Jack Arbiser ,  Brian Pollack ,  Siyuan Xia

IPC分类号： A61K31/351

摘要： This disclosure relates to methods of managing or treating cancer with agents that lower circulating acetoacetate levels, such as hypolipidemic agents, or other agents that antagonize acetoacetate-BRAF V600 mutant binding to attenuate BRAF V600 mutant tumor growth. In certain embodiments, this disclosure relates to methods of treating cancer comprising administering an effective amount of an agent to a subject in need thereof, wherein the agent is dehydroacetic acid, derivative, prodrug, or salt thereof.

公开(公告)号：US20200278357A1

公开(公告)日：2020-09-03

申请号：US16805136

申请日：2020-02-28

申请人： Abbott Laboratories ,  Emory University

发明人： Agim Beshiri ,  Arshed A. Quyyumi

IPC分类号： G01N33/68

摘要： The present disclosure relates to methods for predicting or determining whether a subject with coronary artery disease is likely to experience or develop a major adverse cardiovascular event (MACE) based on comparing the concentration or levels of cardiac troponin I (cTnI) determined by one or more assays before a stress test and then during or after a stress test.

公开(公告)号：US20200277356A1

公开(公告)日：2020-09-03

申请号：US16874121

申请日：2020-05-14

申请人： EMORY UNIVERSITY ,  GEORGIA TECH RESEARCH CORPORATION

发明人： H. Trent Spencer ,  Christopher B. Doering ,  Philip M. Zakas ,  Eric Gaucher

IPC分类号： C07K14/755

摘要： This disclosure relates to recombinant or chimeric FVIII proteins, variants, and vectors encoding the proteins containing one or more ancestral mutations. In certain embodiments, one or more protein domains comprise amino acid sequences that are derived from ancestrally reconstructed amino acid sequences. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising the proteins or vectors and related methods of inducing blood clotting.

公开(公告)号：US20200276219A1

公开(公告)日：2020-09-03

申请号：US16755779

申请日：2018-12-07

申请人： EMORY UNIVERSITY

发明人： George R. PAINTER ,  Gregory R. BLUEMLING ,  Michael G. NATCHUS ,  David GUTHRIE

IPC分类号： A61K31/7068 ,  A61P31/12

摘要： This disclosure relates to certain N4-hydroxycytidine derivatives, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of viral infections, such as Eastern, Western, and Venezuelan Equine Encephalitis (EEE, WEE and VEE, respectively), Chikungunya fever (CHIK), Ebola, Influenza, RSV, and Zika virus infection with the disclosed compounds.