公开(公告)号：US20140301912A1

公开(公告)日：2014-10-09

申请号：US14308468

申请日：2014-06-18

Applicant: Bracco Imaging S.p.A

Inventor： Robert C. Williams, JR. ,  Patrice Marchildon

IPC: C12Q1/18

CPC classification number: G01M3/2853 ,  A61L2/18 ,  A61L2/28 ,  A61M5/00 ,  A61M5/1408 ,  A61M5/1413 ,  A61M5/14232 ,  C12Q1/18 ,  C12Q1/22 ,  G01N31/226 ,  G01N33/50 ,  G01N2013/003 ,  Y10T436/13

Abstract: A fluid delivery system may include a container that houses a medical fluid, a fluid pressurizing unit, and a fluid transfer set that transfers the medical fluid from the container to the fluid pressurizing unit. To validate the integrity and sterility of the fluid delivery system, the system may undergo testing protocols to evaluate the susceptibility of the system to pathogenic ingress, chemical degradation, and/or fluid cross-contamination between patient fluid delivery procedures. The testing protocols may help ensure that delivery system components used during multiple different fluid delivery procedures perform as well as if the components were replaced after each fluid delivery procedure.

公开(公告)号：US20140154671A1

公开(公告)日：2014-06-05

申请号：US14097867

申请日：2013-12-05

Applicant: Bracco Imaging S.p.A

Inventor： Robert C. Williams, JR. ,  Patrice Marchildon

IPC: C12Q1/22 ,  G01N33/50

CPC classification number: G01M3/2853 ,  A61L2/18 ,  A61L2/28 ,  A61M5/00 ,  A61M5/1408 ,  A61M5/1413 ,  A61M5/14232 ,  C12Q1/18 ,  C12Q1/22 ,  G01N31/226 ,  G01N33/50 ,  G01N2013/003 ,  Y10T436/13

Abstract: A fluid delivery system may include a container that houses a medical fluid, a fluid pressurizing unit, and a fluid transfer set that transfers the medical fluid from the container to the fluid pressurizing unit. To validate the integrity and sterility of the fluid delivery system, the system may undergo testing protocols to evaluate the susceptibility of the system to pathogenic ingress, chemical degradation, and/or fluid cross-contamination between patient fluid delivery procedures. The testing protocols may help ensure that delivery system components used during multiple different fluid delivery procedures perform as well as if the components were replaced after each fluid delivery procedure.

公开(公告)号：US20250051267A1

公开(公告)日：2025-02-13

申请号：US18721282

申请日：2022-12-15

Applicant: BRACCO IMAGING S.P.A.

Inventor： Luciano LATTUADA ,  Luca BEVERINA ,  Mauro SASSI ,  Sara MATTIELLO ,  Antonio PAPAGNI ,  Anita ZUCCHI

IPC: C07C237/32

Abstract: The present invention relates to a novel process for the preparation of 2,4,6-triiodoisophthalic bisamide derivatives, which are useful intermediates in the preparation of non-ionic X-ray contrast agents, starting from the corresponding acyl chloride intermediates which are amidated in a mixture of specific hydrotropic solvents in the presence of a low amount of water. In addition, the invention relates to the use of such hydrotropic solvents in the preparation of said 2,4,6-triiodoisophthalic bisamide intermediates to produce non-ionic X-ray contrast agents.

公开(公告)号：US12129563B2

公开(公告)日：2024-10-29

申请号：US18694306

申请日：2022-09-22

Applicant: BRACCO IMAGING S.P.A.

Inventor： Luciano Lattuada ,  Camilla Cavallotti ,  Giovanni Battista Giovenzana ,  Fulvio Uggeri ,  Alessandro Minguzzi ,  Alberto Vertova ,  Letizia Sorti ,  Carlo Morelli

IPC: C25B3/27 ,  C07C231/12 ,  C07C237/46 ,  C25B3/07 ,  C25B3/09 ,  C25B3/11 ,  C25B15/08

CPC classification number: C25B3/27 ,  C07C231/12 ,  C07C237/46 ,  C25B3/07 ,  C25B3/09 ,  C25B3/11 ,  C25B15/081 ,  C25B15/083 ,  C25B15/087

Abstract: The invention is related to a process for preparing a iodinating X-rays contrast agent. More specifically, it relates to a process for the preparation of N,N′-bis-(2,3-dihydroxypropyl)-5-hydroxy-2,4,6-triiodo-1,3-benzenedicarboxaniide (I) by electrochemical iodination of N,N′-(2,3-dihydroxypropyl)-5-hydroxy-1,3-benzenedicarboxamide (II) with molecular iodine (I2) which is in situ electrochemically generated from a source of iodide ions (I−). The iodide ions (I−) are obtained by the dissolution of hydrogen iodide (HI) or an alkali metal iodide in the reaction medium or produced during the reaction of N,N′-(2,3-dihydroxypropyl)-5-hydroxy-1,3-benzenedicarboxamide with I2. The invention also relates to the use of the intermediate compound of formula (I), obtained through the above electrochemical iodination of compound (II), in the preparation of N,N′-bis[2,3-dihydroxypropyl]-5(hydroxyacetyl)methylamino]-2,4,6-triiodo-1,3-benzenedicarboxamide (iomeprol).

公开(公告)号：US12036289B2

公开(公告)日：2024-07-16

申请号：US17199122

申请日：2021-03-11

Applicant: BRACCO IMAGING S.P.A.

Inventor： Roberta Napolitano ,  Luciano Lattuada ,  Zsolt Baranyai ,  Nicole Guidolin ,  Giuseppe Marazzi

IPC: A61B5/055 ,  A61K49/10 ,  C07F5/00 ,  C07D471/08

CPC classification number: A61K49/106 ,  C07F5/003 ,  A61K49/108 ,  C07D471/08

Abstract: The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutaric acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.

公开(公告)号：US20240083880A1

公开(公告)日：2024-03-14

申请号：US18388604

申请日：2023-11-10

Applicant: BRACCO IMAGING S.P.A.

Inventor： Francesco BLASI ,  Federica BUONSANTI ,  Federico CRIVELLIN ,  Andrea FERRARIS ,  Laura ORIO ,  Lorena PIZZUTO ,  Roberta NAPOLITANO ,  Giovanni VALBUSA

IPC: C07D403/10 ,  C07D403/14 ,  C09B23/01

CPC classification number: C07D403/10 ,  C07D403/14 ,  C09B23/0066 ,  C09B23/0075

Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near-infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof.
The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.

公开(公告)号：US11851421B2

公开(公告)日：2023-12-26

申请号：US18010905

申请日：2021-06-22

Applicant: BRACCO IMAGING S.P.A.

Inventor： Francesco Blasi ,  Federica Buonsanti ,  Federico Crivellin ,  Andrea Ferraris ,  Laura Orio ,  Lorena Pizzuto ,  Roberta Napolitano ,  Giovanni Valbusa

IPC: C07D403/10 ,  C09B23/01 ,  C07D403/14

CPC classification number: C07D403/10 ,  C07D403/14 ,  C09B23/0066 ,  C09B23/0075

Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near-infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them. The compounds have formula (I), formula (I), wherein X is direct bond or —O—; Y is a group selected from linear or branched C1-C6 alkyl, C3-C7 cycloalkyl and heterocyclyl, substituted by at least two hydroxyl groups; R1 and R2 are each independently a linear or branched C1-C6 alkyl substituted by a group selected from —SO3H, —COOH, —CONH2 and —COO—C1-C6 alkyl; and R3 is hydrogen, —SO3H or a linear or branched C1-C6 alkyl substituted by —COOH or —CONH—Y, wherein Y is a group selected from linear or branched C1-C6 alkyl, C3-C7 cycloalkyl and heterocyclyl, substituted by at least two hydroxyl groups.

公开(公告)号：US11684682B2

公开(公告)日：2023-06-27

申请号：US17292479

申请日：2019-11-12

Applicant: BRACCO IMAGING S.P.A.

Inventor： Zsolt Baranyai ,  Simona Ghiani ,  Alessandro Maiocchi ,  Ivan Hawala

IPC: A61K51/08 ,  A61P35/00 ,  C07K7/64

CPC classification number: A61K51/08 ,  A61P35/00 ,  C07K7/64

Abstract: A chelating compound of formula (I) or a pharmaceutically acceptable salt thereof and its complexes with metals or radioisotopes thereof. The invention further relates to the preparation of such ligand and complexes as well as to their use as diagnostic or therapeutic agents.

公开(公告)号：US20220370646A1

公开(公告)日：2022-11-24

申请号：US17771168

申请日：2020-10-20

Applicant: BRACCO IMAGING S.P.A.

Inventor： Zsolt BARANYAI ,  Mariangela BOCCALON ,  Federica BUONSANTI ,  Federico CRIVELLIN ,  Alessandro MAIOCCHI ,  Roberta MAZZON ,  Fabio TEDOLDI ,  Fulvio UGGERI

IPC: A61K49/10

Abstract: The present invention relates to pharmaceutical compositions comprising an gadolinium-complex and a saturated macrocyclic tetraamine that find application in diagnostic imaging as diagnostic agents, in particular as contrast agents having improved tolerability, specifically in Magnetic Resonance Imaging (MRI), and to their preparation.

公开(公告)号：US11274308B2

公开(公告)日：2022-03-15

申请号：US17262835

申请日：2019-07-24

Applicant: BRACCO IMAGING S.P.A.

Inventor： Vittorio De Franciscis ,  Silvia Catuogno ,  Carla Lucia Esposito ,  Alessandro Maiocchi ,  Margherita Iaboni ,  Luisa Poggi ,  Erika Reitano

IPC: C12N15/115 ,  C12Q1/68

Abstract: The present invention provides nucleic acid aptamers binding to the Intercellular Adhesion Molecule-1 (ICAM-1), derivatives and conjugates thereof and their use as diagnostic tools, particularly for the imaging of organs and tissues expressing ICAM-1, or as therapeutic agents for prevention or treatment of ICAM-1-related diseases.