公开(公告)号：US20220112552A1

公开(公告)日：2022-04-14

申请号：US17560928

申请日：2021-12-23

申请人： The Trustees of Columbia University in the City of New York

发明人： Jingyue Ju ,  Huanyan Cao ,  Zengmin Li ,  Qinglin Meng ,  Jia Guo ,  Shenglong Zhang ,  Lin Yu

IPC分类号： C12Q1/6869 ,  C07H19/06 ,  C07H19/16 ,  C07H19/14 ,  C07H19/20 ,  C07H19/10

摘要： This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.

公开(公告)号：US09670539B2

公开(公告)日：2017-06-06

申请号：US14859853

申请日：2015-09-21

申请人： The Trustees of Columbia University in the City of New York

发明人： Jingyue Ju ,  Huanyan Cao ,  Zengmin Li ,  Qinglin Meng ,  Jia Guo ,  Shenglong Zhang ,  Lin Yu

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H19/06 ,  C07H19/10 ,  C07H19/14 ,  C07H19/16 ,  C07H19/20

CPC分类号： C12Q1/6869 ,  C07H19/06 ,  C07H19/10 ,  C07H19/14 ,  C07H19/16 ,  C07H19/20 ,  C12Q2525/301 ,  C12Q2537/157

摘要： This invention provides novel azido linkers for deoxynucleotide analogs having a detectable marker attached thereto.

公开(公告)号：US12100121B2

公开(公告)日：2024-09-24

申请号：US17347948

申请日：2021-06-15

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Jia Guo ,  Scott A. Small

IPC分类号： G06T5/00 ,  G06T5/50 ,  G16H30/20 ,  G16H30/40 ,  G16H50/20 ,  G16H50/50

CPC分类号： G06T5/00 ,  G06T5/50 ,  G16H30/20 ,  G16H30/40 ,  G16H50/20 ,  G16H50/50 ,  G06T2207/10096 ,  G06T2207/20081 ,  G06T2207/20084 ,  G06T2207/30016

摘要： An exemplary system, method, and computer-accessible medium for detection of structural disorder(s) of patient(s) can be provided which can include, for example, receiving magnetic resonance imaging (MRI) information of the portion(s), generating gadolinium (“Gd”) enhanced map(s) based on the MRI information using a machine learning procedure(s), and detecting the structural disorder(s) of the patient(s) based on a GD contrast of the Gd enhanced map(s). The Gd enhanced map(s) can be a full dosage Gd enhanced map. The machine learning procedure can be a convolutional neural network. The MRI information can include (i) a low-dosage Gd MRI scan(s), or (ii) a Gd-free MRI scan(s). The Gd contrast can be generated in the Gd enhanced map(s) using a T2-weighted MRI image of the portion(s). Structural disorder(s) can include Stroke, tumor, trauma, infection, Multiple sclerosis and/or other inflammatory disease.

公开(公告)号：US20220290227A1

公开(公告)日：2022-09-15

申请号：US17576184

申请日：2022-01-14

申请人： The Trustees of Columbia University in the City of New York

发明人： Jingyue Ju ,  Dae Hyun Kim ,  Jia Guo ,  Qinglin Meng ,  Zengmin Li ,  Huanyan Cao

IPC分类号： C12Q1/6874 ,  C07H19/04 ,  C12Q1/6869 ,  C12Q1/6876

摘要： This invention provides a process for sequencing nucleic acids using 3′ modified deoxynucleotide analogues or 3′ modified deoxyinosine triphosphate analogues, and 3′ modified dideoxynucleotide analogues having a detectable marker attached thereto.

公开(公告)号：US10144961B2

公开(公告)日：2018-12-04

申请号：US15596379

申请日：2017-05-16

申请人： The Trustees of Columbia University in the City of New York

发明人： Jingyue Ju ,  Huanyan Cao ,  Zengmin Li ,  Qinglin Meng ,  Jia Guo ,  Shenglong Zhang ,  Lin Yu

IPC分类号： C12Q1/68 ,  C12Q1/6869 ,  C07H19/06 ,  C07H19/10 ,  C07H19/14 ,  C07H19/16 ,  C07H19/20

摘要： This invention provides novel azido linkers for deoxynucleotide analogs having a detectable marker attached thereto.