公开(公告)号：US10914736B2

公开(公告)日：2021-02-09

申请号：US15022298

申请日：2013-09-16

申请人： SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION

发明人： Tai Hyun Park ,  Seung Hun Hong ,  Hyun Seok Song ,  Hye Jun Jin ,  Sae Ryun Ahn

IPC分类号： C07K14/705 ,  G01N33/543 ,  G01N33/74 ,  G01N27/414 ,  G01N33/53 ,  H01L51/00 ,  H01L51/05

摘要： The present invention relates to a nanovesicle comprising a heterodimeric G-protein coupled receptor, a method for preparing the nanovesicle, a field effect transistor-based taste sensor comprising the nanovesicle, and a method for manufacturing the taste sensor. The field effect transistor based taste sensor functionalized by the nanovesicle comprising the heterodimer G-protein coupled receptor according to the present invention has excellent sensitivity and selectivity and may highly specifically detect a sweet taste substance in real time, by using the heterodimeric G-protein coupled receptor and the nanovesicle comprising the same.

公开(公告)号：US12099060B2

公开(公告)日：2024-09-24

申请号：US16839623

申请日：2020-04-03

申请人： Seoul National University R&DB Foundation

发明人： Tai Hyun Park ,  Seung Hun Hong ,  Hyun Seok Song ,  Hye Jun Jin ,  Sae Ryun Ahn

IPC分类号： G01N21/64 ,  B01F23/00 ,  B01F23/41 ,  B01F101/23 ,  B23Q17/24 ,  C07K14/705 ,  C12M1/34 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/686 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/39 ,  G01N21/45 ,  G01N27/414 ,  G01N30/12 ,  G01N30/68 ,  G01N30/70 ,  G01N30/72 ,  G01N30/88 ,  G01N33/00 ,  G01N33/18 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N33/68 ,  G01N33/74 ,  H10K10/46 ,  H10K85/00 ,  H10K85/20

CPC分类号： G01N33/5438 ,  C07K14/705 ,  G01N27/4145 ,  G01N33/5308 ,  G01N33/54373 ,  G01N33/74 ,  H10K10/46 ,  H10K85/761 ,  G01N2333/705 ,  G01N2333/726 ,  G01N2400/00 ,  H10K85/225

摘要： The present invention relates to a nanovesicle comprising a heterodimeric G-protein coupled receptor, a method for preparing the nanovesicle, a field effect transistor-based taste sensor comprising the nanovesicle, and a method for manufacturing the taste sensor. The field effect transistor based taste sensor functionalized by the nanovesicle comprising the heterodimer G-protein coupled receptor according to the present invention has excellent sensitivity and selectivity and may highly specifically detect a sweet taste substance in real time, by using the heterodimeric G-protein coupled receptor and the nanovesicle comprising the same.

公开(公告)号：US20200271644A1

公开(公告)日：2020-08-27

申请号：US16839623

申请日：2020-04-03

申请人： Seoul National University R&DB Foundation

发明人： Tai Hyun Park ,  Seung Hun Hong ,  Hyun Seok Song ,  Hye Jun Jin ,  Sae Ryun Ahn

IPC分类号： G01N33/543 ,  G01N33/74 ,  C07K14/705 ,  G01N27/414 ,  G01N33/53 ,  H01L51/00 ,  H01L51/05

摘要： The present invention relates to a nanovesicle comprising a heterodimeric G-protein coupled receptor, a method for preparing the nanovesicle, a field effect transistor-based taste sensor comprising the nanovesicle, and a method for manufacturing the taste sensor. The field effect transistor based taste sensor functionalized by the nanovesicle comprising the heterodimer G-protein coupled receptor according to the present invention has excellent sensitivity and selectivity and may highly specifically detect a sweet taste substance in real time, by using the heterodimeric G-protein coupled receptor and the nanovesicle comprising the same.

公开(公告)号：US20160231316A1

公开(公告)日：2016-08-11

申请号：US15022298

申请日：2013-09-16

申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

发明人： Tai Hyun Park ,  Seung Hun Hong ,  Hyun Seok Song ,  Hye Jun Jin ,  Sae Ryun An

IPC分类号： G01N33/543 ,  H01L51/05 ,  G01N27/414 ,  C07K14/705 ,  G01N33/53

CPC分类号： G01N33/5438 ,  C07K14/705 ,  G01N27/4145 ,  G01N33/5308 ,  G01N33/54373 ,  G01N33/74 ,  G01N2333/705 ,  G01N2333/726 ,  G01N2400/00 ,  H01L51/0049 ,  H01L51/0093 ,  H01L51/0508

摘要： The present invention relates to a nanovesicle comprising a heterodimeric G-protein coupled receptor, a method for preparing the nanovesicle, a field effect transistor-based taste sensor comprising the nanovesicle, and a method for manufacturing the taste sensor. The field effect transistor based taste sensor functionalized by the nanovesicle comprising the heterodimer G-protein coupled receptor according to the present invention has excellent sensitivity and selectivity and may highly specifically detect a sweet taste substance in real time, by using the heterodimeric G-protein coupled receptor and the nanovesicle comprising the same.

摘要翻译： 本发明涉及包含异二聚体G蛋白偶联受体的纳米囊，制备纳米囊的方法，包含纳米囊的基于场效应晶体管的味觉传感器，以及制造味觉传感器的方法。 由包含根据本发明的异源二聚体G蛋白偶联受体的纳米囊体功能化的基于场效应晶体管的味觉传感器具有优异的灵敏度和选择性，并且可以通过使用异二聚体G蛋白偶联来高度特异性地检测甜味物质 受体和包含其的纳米囊。