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公开(公告)号：US10053513B2
公开(公告)日：2018-08-21
申请号：US14818864
申请日：2015-08-05
Applicant: Janssen Biotech, Inc.
Inventor： Stephen McCarthy , Bernard Scallon , Susan Tam , William Strohl , Omid Vafa
CPC classification number: C07K16/32 , A61K2039/505 , C07K16/00 , C07K16/2887 , C07K2317/52 , C07K2317/524 , C07K2317/54 , C07K2317/70 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/75 , C07K2317/92
Abstract: Antibody and other Fc-containing molecules with variations in the Fc region with reduced binding to Fc gamma receptors and resulting activity and can be used in the treatment of various diseases and disorders.
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公开(公告)号：US09862766B2
公开(公告)日：2018-01-09
申请号：US15432636
申请日：2017-02-14
Applicant: Janssen Biotech, Inc.
Inventor： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
IPC: A61K38/20 , C07K16/24 , C07K14/54 , A61K31/137 , A61K31/56 , A61K38/27 , A61K39/395 , A61K45/06 , A61K51/00 , C12Q1/68 , A61K39/00
CPC classification number: C07K16/244 , A61K31/137 , A61K31/56 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K51/00 , A61K2039/505 , C07K14/54 , C07K14/5434 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C12Q1/6876
Abstract: An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
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公开(公告)号：US09828424B2
公开(公告)日：2017-11-28
申请号：US15075248
申请日：2016-03-21
Applicant: Janssen Biotech, Inc.
Inventor： George Heavner , David M. Knight , Jill Giles-Komar , Bernard Scallon , David Shealy
IPC: C07K16/24 , A61K9/19 , A61K39/395 , A61K38/18 , A61K38/19 , A61K38/27 , A61K45/06 , C07K16/42 , G01N33/566 , A61K39/00
CPC classification number: C07K16/241 , A61K9/19 , A61K38/1816 , A61K38/19 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/42 , C07K16/4241 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/566 , Y02A50/386 , Y02A50/412 , Y10S514/825 , Y10S514/826
Abstract: The present invention relates to anti-TNF antibodies comprising all of the heavy chain variable CDR regions of SEQ ID NOS:1, 2 and 3 and/or all of the light chain variable CDR regions of SEQ ID NOS:4, 5 and 6, specific for at least one human tumor necrosis factor alpha (TNF) protein or fragment thereof, as well as nucleic acids encoding such anti-TNF antibodies, complementary nucleic acids, vectors, host cells, production methods and therapeutic methods.
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公开(公告)号：US09738702B2
公开(公告)日：2017-08-22
申请号：US14656149
申请日：2015-03-12
Applicant: Janssen Biotech, Inc.
Inventor： Thomas Nesspor , Bernard Scallon
IPC: C07K16/10
CPC classification number: C07K16/1027 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/524 , C07K2317/72 , C07K2317/94
Abstract: The antibodies, immunoglobulin constructs, or immunoglobulin fusion proteins whose in vivo half-life is increased in ferrets by a modified ferret IgG Fc region can be useful to test therapeutics in ferrets and ferret models.
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公开(公告)号：US20150337053A1
公开(公告)日：2015-11-26
申请号：US14818864
申请日：2015-08-05
Applicant: Janssen Biotech, Inc.
Inventor： Stephen McCarthy , Bernard Scallon , Susan Tam , William Strohl , Omid Vafa
CPC classification number: C07K16/32 , A61K2039/505 , C07K16/00 , C07K16/2887 , C07K2317/52 , C07K2317/524 , C07K2317/54 , C07K2317/70 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/75 , C07K2317/92
Abstract: Antibody and other Fc-containing molecules with variations in the Fc region with reduced binding to Fc gamma receptors and resulting activity and can be used in the treatment of various diseases and disorders.
Abstract translation: 抗体和其他具有Fc区变化的含Fc分子，其与Fcγ受体的结合降低并导致活性，并可用于治疗各种疾病和病症。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20140178295A1
公开(公告)日：2014-06-26
申请号：US14190893
申请日：2014-02-26
Applicant: Janssen Biotech, Inc.
Inventor： Jill Giles-Komar , David M. Knight , David Peritt , Bernard Scallon , David Shealy
IPC: C07K16/24 , A61K39/395 , A61K45/06
CPC classification number: C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders, such as psoriasis.
Abstract translation: 分离的抗IL-12抗体，编码抗体或抗体部分的核酸，载体，宿主细胞和制备方法可用于产生用于治疗和/或诊断IL-12相关病症，疾病和障碍的抗体或部分， 如牛皮癣。
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7.发明申请Method for Treating Psoriatic Arthritis By Administering An Anti-IL-12 Antibody 有权通过施用抗IL-12抗体治疗银屑病关节炎的方法公开(公告)号：US20130129617A1
公开(公告)日：2013-05-23
申请号：US13669894
申请日：2012-11-06
Applicant: Janssen Biotech, Inc.
Inventor： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
IPC: C07K16/24 , A61K45/06 , A61K38/19 , A61K38/27 , A61K51/00 , A61K31/137 , A61K39/395 , A61K31/56
CPC classification number: C07K16/244 , A61K31/137 , A61K31/56 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K51/00 , A61K2039/505 , C07K14/54 , C07K14/5434 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C12Q1/6876
Abstract: An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in treating IL-12-related disorders, such as psoriatic arthritis.
Abstract translation: 结合IL-12蛋白的一部分对应于至少一个氨基酸残基的抗IL-12抗体，其选自残基15,17-21,23,40-43,45-47,54 -56和58-62的IL-12的p40亚基的氨基酸序列，包括编码至少一种抗IL-12抗体，载体，宿主细胞，转基因动物或植物的分离的核酸，以及制备方法 并且其应用具有治疗IL-12相关疾病如牛皮癣关节炎的应用。
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公开(公告)号：US20200062841A1
公开(公告)日：2020-02-27
申请号：US16677120
申请日：2019-11-07
Applicant: Janssen Biotech, Inc.
Inventor： Jill Giles-Komar , David M. Knight , David Peritt , Bernard Scallon , David Shealy
IPC: C07K16/24 , A61K39/395 , A61K45/06
Abstract: Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders, such as systemic lupus erythematosus.
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公开(公告)号：US10519231B2
公开(公告)日：2019-12-31
申请号：US16284316
申请日：2019-02-25
Applicant: Janssen Biotech, Inc.
Inventor： Jill Giles-Komar , David M. Knight , David Peritt , Bernard Scallon , David Shealy
IPC: A61K39/395 , C07K16/24 , A61K45/06 , A61K39/00
Abstract: Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders, such as systemic lupus erythematosus.
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公开(公告)号：US20180319893A1
公开(公告)日：2018-11-08
申请号：US16037304
申请日：2018-07-17
Applicant: Janssen Biotech, Inc.
Inventor： McCarthy Stephen , Bernard Scallon , William Strohl , Susan Tam , Omid Vafa
CPC classification number: C07K16/32 , A61K2039/505 , C07K16/00 , C07K16/2887 , C07K2317/52 , C07K2317/524 , C07K2317/54 , C07K2317/70 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/75 , C07K2317/92
Abstract: Antibody and other Fc-containing molecules with variations in the Fc region with reduced binding to Fc gamma receptors and resulting activity and can be used in the treatment of various diseases and disorders.
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