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    Sample preparation, processing and analysis systems
    1.
    发明授权
    Sample preparation, processing and analysis systems 有权

    公开(公告)号：US12168798B2

    公开(公告)日：2024-12-17

    申请号：US17119874

    申请日：2020-12-11

    Applicant: Integenx Inc.

    Inventor： David Eberhart ,  Yuan Li ,  James Ogg ,  Ezra Van Gelder ,  Stephen J. Williams ,  Timothy Woudenberg ,  Dean S. Burgi ,  William D. Nielsen

    IPC: C12Q1/686 ,  B01L3/00 ,  B01L7/00 ,  G01N27/447 ,  G01N35/00

    Abstract: This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.

    Cartridges and Instruments for Sample Analysis
    2.
    发明申请
    Cartridges and Instruments for Sample Analysis 有权

    公开(公告)号：US20210278427A1

    公开(公告)日：2021-09-09

    申请号：US17211212

    申请日：2021-03-24

    Applicant: INTEGENX INC.

    Inventor： James Ogg ,  David Eberhart ,  William D. Nielsen ,  Helen Franklin ,  Stevan B. Jovanovich

    IPC: G01N35/00 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/6818 ,  C12Q1/686 ,  C12Q1/6888

    Abstract: Provided herein are instruments and cartridges for processing samples. The cartridges include fluidic circuits in which fluid movement can be regulated by diaphragm valves. In certain cartridges, deformable material providing a diaphragm contacts an interface in the instrument that actuates the diaphragm directly, without intervening actuation layer. Certain cartridges have a plurality of fluidic circuits and fluid distribution channels or pneumatic distribution channels configured to deliver fluids or pneumatic pressure to any of the fluidic circuits, selectively. Certain cartridges have compartments containing on-board reagents. Compartments can be closed by a film attached to a body the cartridge through a heat seal.

    Cartridges and instruments for sample analysis
    3.
    发明授权
    Cartridges and instruments for sample analysis 有权

    公开(公告)号：US10989723B2

    公开(公告)日：2021-04-27

    申请号：US16258412

    申请日：2019-01-25

    Applicant: IntegenX Inc.

    Inventor： James Ogg ,  David Eberhart ,  William D. Nielsen ,  Helen Franklin ,  Stevan B. Jovanovich

    IPC: B01L3/00 ,  G01N35/00 ,  B01L7/00 ,  C12Q1/6818 ,  C12Q1/686 ,  C12Q1/6888

    Abstract: Provided herein are instruments and cartridges for processing samples. The cartridges include fluidic circuits in which fluid movement can be regulated by diaphragm valves. In certain cartridges, deformable material providing a diaphragm contacts an interface in the instrument that actuates the diaphragm directly, without intervening actuation layer. Certain cartridges have a plurality of fluidic circuits and fluid distribution channels or pneumatic distribution channels configured to deliver fluids or pneumatic pressure to any of the fluidic circuits, selectively. Certain cartridges have compartments containing on-board reagents. Compartments can be closed by a film attached to a body the cartridge through a heat seal.

    Sample Preparation, Processing and Analysis Systems
    4.
    发明申请
    Sample Preparation, Processing and Analysis Systems 有权

    公开(公告)号：US20210277445A1

    公开(公告)日：2021-09-09

    申请号：US17119874

    申请日：2020-12-11

    Applicant: Integenx Inc.

    Inventor： David Eberhart ,  Yuan Li ,  James Ogg ,  Ezra Van Gelder ,  Stephen J. Williams ,  Timothy Woudenberg ,  Dean S. Burgi ,  William D. Nielsen

    IPC: C12Q1/686 ,  B01L3/00 ,  B01L7/00

    Abstract: This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.

    Cartridges and instruments for sample analysis
    5.
    发明授权
    Cartridges and instruments for sample analysis 有权

    公开(公告)号：US10191071B2

    公开(公告)日：2019-01-29

    申请号：US15037039

    申请日：2014-11-17

    Applicant: IntegenX Inc.

    Inventor： James Ogg ,  David Eberhart ,  William D. Nielsen ,  Helen Franklin ,  Stevan B. Jovanovich

    IPC: G01N35/00 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/6818 ,  C12Q1/686 ,  C12Q1/6888

    Abstract: Provided herein are instruments and cartridges for processing samples. The cartridges include fluidic circuits in which fluid movement can be regulated by diaphragm valves. In certain cartridges, deformable material providing a diaphragm contacts an interface in the instrument that actuates the diaphragm directly, without intervening actuation layer. Certain cartridges have a plurality of fluidic circuits and fluid distribution channels or pneumatic distribution channels configured to deliver fluids or pneumatic pressure to any of the fluidic circuits, selectively. Certain cartridges have compartments containing on-board reagents. Compartments can be closed by a film attached to a body the cartridge through a heat seal.

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