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    Sample preparation, processing and analysis systems
    1.
    发明授权
    Sample preparation, processing and analysis systems 有权

    公开(公告)号：US12168798B2

    公开(公告)日：2024-12-17

    申请号：US17119874

    申请日：2020-12-11

    Applicant: Integenx Inc.

    Inventor： David Eberhart ,  Yuan Li ,  James Ogg ,  Ezra Van Gelder ,  Stephen J. Williams ,  Timothy Woudenberg ,  Dean S. Burgi ,  William D. Nielsen

    IPC: C12Q1/686 ,  B01L3/00 ,  B01L7/00 ,  G01N27/447 ,  G01N35/00

    Abstract: This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.

    Methods and Devices for Multi-Color, Out-of-Phase Detection in Electrophoresis
    2.
    发明申请
    Methods and Devices for Multi-Color, Out-of-Phase Detection in Electrophoresis 审中-公开
    电泳中多色，异相检测的方法和装置

    公开(公告)号：US20140065628A1

    公开(公告)日：2014-03-06

    申请号：US13966252

    申请日：2013-08-13

    Applicant: IntegenX Inc.

    Inventor： Ezra Van Gelder ,  Stephen J. Williams

    IPC: G01N27/447

    CPC classification number: G01N27/44721 ,  G01N27/44726 ,  G01N27/44791

    Abstract: The disclosure provides methods and devices for separating and detecting nucleic acid fragments labeled with a plurality of spectrally resolvable dyes using a single light source or multiple light sources. Use of a greater number of light sources increases the number of spectrally resolvable dyes that can be interrogated. Labeling fragments with a greater number of spectrally resolvable dyes permits more overlapping of fragments with differentiation of the fragments, and thus separation can be conducted on a smaller range of fragment sizes/lengths. To improve the detection sensitivity of a detection system employing multiple light sources, light emitted by the light sources can be spatially separated from one another and/or the intensity of each of the light sources can be modulated. Each of the one or more light sources can be, e.g., a laser or a light-emitting diode. The methods and devices of the disclosure are useful for performing genetic analysis, e.g., analysis of a plurality of STR markers utilized in a forensic database (e.g., CODIS) to identify humans.

    Abstract translation: 本公开提供了用于使用单个光源或多个光源分离和检测用多个可光谱可分辨染料标记的核酸片段的方法和装置。 使用更多数量的光源可增加可询问的光谱可分辨染料的数量。 具有更多数量的光谱可分辨染料的标记片段允许具有片段分化的片段更多的重叠，因此可以在更小的片段大小/长度范围上进行分离。 为了提高使用多个光源的检测系统的检测灵敏度，光源发射的光可以在空间上彼此分离和/或可以调制每个光源的强度。 一个或多个光源中的每一个可以是例如激光器或发光二极管。 本公开的方法和装置可用于进行遗传分析，例如分析在法医数据库（例如，CODIS）中使用的多个STR标记以鉴定人。

    Sample Preparation, Processing and Analysis Systems
    4.
    发明申请
    Sample Preparation, Processing and Analysis Systems 有权

    公开(公告)号：US20210277445A1

    公开(公告)日：2021-09-09

    申请号：US17119874

    申请日：2020-12-11

    Applicant: Integenx Inc.

    Inventor： David Eberhart ,  Yuan Li ,  James Ogg ,  Ezra Van Gelder ,  Stephen J. Williams ,  Timothy Woudenberg ,  Dean S. Burgi ,  William D. Nielsen

    IPC: C12Q1/686 ,  B01L3/00 ,  B01L7/00

    Abstract: This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.

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