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公开(公告)号：US20250003949A1
公开(公告)日：2025-01-02
申请号：US18739556
申请日：2024-06-11
Applicant: Hamamatsu Photonics K.K.
Inventor： Tokio TAKAGI , Toyohiko YAMAUCHI , Tatsuo DOUGAKIUCHI , Yoichi KAWADA , Yoshiyuki SHIMIZU , Gen TAKEBE
IPC: G01N33/483 , G01N1/28 , G01N1/30 , G01N21/64
Abstract: A cell sample measurement apparatus includes a sample stage for placing an object cell sample containing a plurality of cells cultured on a culture dish, an evaluation light irradiation unit for irradiating N irradiation regions set by dividing a culture region in the object cell sample with evaluation light having a wavelength in a mid-infrared region with irradiation amounts different from each other, a dead cell number measurement unit for measuring a dead cell number generated according to the irradiation amount of the evaluation light in each of the N irradiation regions, and a culture state analysis unit for obtaining, for the object cell sample, an object correlation between the irradiation amount of the evaluation light and the dead cell number for the N irradiation regions serving as an index of evaluation of a culture state of the object cell sample.
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公开(公告)号：US20180236257A1
公开(公告)日：2018-08-23
申请号：US15896267
申请日：2018-02-14
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Gen TAKEBE , Yoshiyuki SHIMIZU , Toyohiko YAMAUCHI , Tatsuo DOUGAKIUCHI
CPC classification number: A61N5/062 , A61N5/0622 , A61N2005/0659 , C12M35/02 , C12N13/00 , C12N2529/10
Abstract: A cell stimulation method includes continuously emitting mid-infrared light to a living cell and thus changing an ion concentration of the cell or changing ion concentrations of the cell and other cells disposed around the cell.
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3.发明申请公开(公告)号：US20190307330A1
公开(公告)日：2019-10-10
申请号：US16314877
申请日：2017-06-27
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Hiroyuki OKADA , Tsuyoshi KOSUGI , Yoshiyuki SHIMIZU , Yohei TAKATA
Abstract: A light output monitoring apparatus includes a light receiving unit, an attachment unit, an adapter, and a protective cap, and monitors a power of light output from a light emitting end of a catheter incorporating an optical fiber. The protective cap includes an insertion opening into which a part of the catheter of a predetermined range on the light emitting end side is removably inserted, includes a window portion for transmitting the light output from the light emitting end of the catheter, and is fixed in position by being inserted into a through-hole of the adapter. The adapter is fixed in position by being attached to the attachment unit.
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公开(公告)号：US20140194725A1
公开(公告)日：2014-07-10
申请号：US14208479
申请日：2014-03-13
Applicant: Hamamatsu Photonics K.K.
Inventor： Akihiro KAKIMOTO , Yoshiyuki SHIMIZU , Tsuyoshi KOSUGI , Hiroyuki OKADA
IPC: A61B5/00
CPC classification number: A61B5/0042 , A61B5/055 , A61B5/4088 , A61B6/03 , G06F19/00 , G06T7/0012 , G06T2207/10072 , G06T2207/30016 , G16H50/20
Abstract: An object of the present invention is to perform a more accurate and detailed diagnosis of a brain disease.A diagnosis server 10 of the brain disease diagnosis system 1 for diagnosing a brain disease of an examined person includes: an acquiring unit 11 for acquiring a brain image of the examined person so as to obtain an acquired image; a region setting unit 12 for setting a plurality of regions in the acquired image; an individual index value calculating unit 13 for calculating an individual index value based on a pixel value of the acquired image, in each of the plurality of regions; a whole index value calculating unit 14 for calculating a whole index value by weighting the individual index value of each of the plurality of regions; a diagnosis unit 15 for diagnosing the brain disease of the examined person based on the whole index value; and an output unit 16 for outputting information indicating a diagnosis outcome.
Abstract translation: 本发明的目的是对脑疾病进行更准确和详细的诊断。 用于诊断被检查人的脑疾病的脑疾病诊断系统1的诊断服务器10包括：获取单元11，用于获取被检查人的脑图像以获得获取的图像; 区域设定单元12，用于设置获取图像中的多个区域; 个体索引值计算单元13，用于在多个区域中的每一个中基于所获取的图像的像素值来计算各个索引值; 整体索引值计算单元14，用于通过对多个区域中的每个区域的各个索引值进行加权来计算整个索引值; 诊断单元15，用于基于整个指标值诊断被检查人的脑部疾病; 以及用于输出指示诊断结果的信息的输出单元16。
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Patent Agency Ranking
公开(公告)号：US20250002836A1
公开(公告)日：2025-01-02
申请号：US18739573
申请日：2024-06-11
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Tokio TAKAGI , Toyohiko YAMAUCHI , Tatsuo DOUGAKIUCHI , Yoichi KAWADA , Yoshiyuki SHIMIZU , Gen TAKEBE
Abstract: A cell sample evaluation apparatus includes an evaluation light irradiation unit for irradiating an irradiation region set in a culture region of a plurality of cells in an object cell sample with evaluation light having a wavelength in a mid-infrared region under a predetermined irradiation condition, a dead cell number measurement unit for measuring a dead cell number generated according to an irradiation amount of the evaluation light in the irradiation region of the object cell sample, and a culture state analysis unit for evaluating a culture state of the object cell sample by obtaining an object correlation between the irradiation amount of the evaluation light and the dead cell number for the object cell sample and comparing a reference correlation between the irradiation amount of the evaluation light and the dead cell number for a reference cell sample and the object correlation.
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公开(公告)号：US20210052326A1
公开(公告)日：2021-02-25
申请号：US16613191
申请日：2018-05-15
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Yohei TAKATA , Yoshiyuki SHIMIZU , Tsuyoshi KOSUGI , Hiroyuki OKADA
IPC: A61B18/24
Abstract: A catheter kit includes a catheter having an optical fiber, and a catheter accommodating tool which accommodates the catheter. The catheter accommodating tool has a tubular hoop, and a protection cap which is provided to the hoop. The protection cap has a transmission window through which laser light L output from the catheter passes.
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公开(公告)号：US20200170706A1
公开(公告)日：2020-06-04
申请号：US16613239
申请日：2018-05-15
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Yohei TAKATA , Yoshiyuki SHIMIZU , Tsuyoshi KOSUGI , Hiroyuki OKADA
Abstract: A light measurement device measures the intensity of laser light output from a catheter tip end portion of a catheter having a built-in optical fiber. The light measurement device includes a light receiving part which receives the laser light output from the catheter tip end portion and a mounting part which is disposed at a position facing the light receiving part. The mounting part defines a position of a tubular hoop, which accommodates the catheter, with respect to the light receiving part. In a state in which the position of the hoop is defined by the mounting part, the light measurement device obtains the intensity of the laser light by inputting the laser light to the light receiving part.
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公开(公告)号：US20200170705A1
公开(公告)日：2020-06-04
申请号：US16613197
申请日：2018-05-15
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Yohei TAKATA , Yoshiyuki SHIMIZU , Tsuyoshi KOSUGI , Hiroyuki OKADA
Abstract: A catheter kit includes a catheter having an optical fiber, and a catheter accommodating tool which accommodates the catheter. The catheter accommodating tool has a tubular hoop, and a position adjustment mechanism provided at the hoop. The hoop has a hoop tip end portion at which a catheter tip end portion from which laser light transmitted through the optical fiber is emitted is disposed, and a hoop base end portion which is opposite to the hoop tip end portion. The position adjustment mechanism is provided at the hoop base end portion and changes a position of the catheter tip end portion with respect to the hoop tip end portion.
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公开(公告)号：US20160313182A1
公开(公告)日：2016-10-27
申请号：US15131390
申请日：2016-04-18
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Yoichi KAWADA , Yoshiyuki SHIMIZU , Toyohiko YAMAUCHI
CPC classification number: G01J3/0229 , G01J3/42 , G01J2003/1213 , G01N2021/3595
Abstract: A spectroscopic measurement apparatus includes a light source, a diffraction grating being a spectroscopic unit, a spatial filter unit, a detection unit, and an analysis unit. The diffraction grating spatially disperses light from the light source, and outputs the light to different optical paths according to a wavelength. The spatial filter unit inputs the light from the diffraction grating to different positions according to the wavelength, applies loss depending on the wavelength to the light, and outputs the light. The detection unit detects the intensity of the light from the spatial filter unit. The analysis unit obtains the intensities of light in an absorption band and light in a non-absorption band of a component in a measurement sample on an optical path between the light source and the detection unit based on the detection result, and evaluates the component in the measurement sample.
Abstract translation: 光谱测量装置包括光源，衍射光栅是分光单元，空间滤光单元，检测单元和分析单元。 衍射光栅在空间上分散来自光源的光，并根据波长将光输出到不同的光路。 空间滤波器单元根据波长将来自衍射光栅的光输入到不同的位置，根据对光的波长施加损耗，并输出光。 检测单元检测来自空间滤波器单元的光的强度。 分析单元基于检测结果，在光源和检测单元之间的光路上获得吸收带中的光的强度和测量样本中的成分的非吸收带中的光，并且评估其中的分量 测量样品。
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