公开(公告)号：US20190307330A1

公开(公告)日：2019-10-10

申请号：US16314877

申请日：2017-06-27

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Hiroyuki OKADA ,  Tsuyoshi KOSUGI ,  Yoshiyuki SHIMIZU ,  Yohei TAKATA

IPC: A61B5/00 ,  A61B18/24 ,  G02B6/42

Abstract: A light output monitoring apparatus includes a light receiving unit, an attachment unit, an adapter, and a protective cap, and monitors a power of light output from a light emitting end of a catheter incorporating an optical fiber. The protective cap includes an insertion opening into which a part of the catheter of a predetermined range on the light emitting end side is removably inserted, includes a window portion for transmitting the light output from the light emitting end of the catheter, and is fixed in position by being inserted into a through-hole of the adapter. The adapter is fixed in position by being attached to the attachment unit.

公开(公告)号：US20180273498A1

公开(公告)日：2018-09-27

申请号：US15763926

申请日：2016-08-15

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Akinori ODA ,  Hiroshi SATOZONO ,  Tomomi SHINKE ,  Yohei TAKATA

IPC: C07D277/66 ,  G01N33/52

CPC classification number: C07D277/66 ,  G01N33/52 ,  G01N33/6893 ,  G01N2333/4709

Abstract: The present invention relates to a method for purifying pure thioflavin T in having a step of preparing a thioflavin T solution in which crude thioflavin T is dissolved in a polar solvent, a step of bringing the thioflavin T solution into contact with a non-polar polymeric porous body, and a step of separating the thioflavin T solution after the contact from the non-polar polymeric porous body.

公开(公告)号：US20210052326A1

公开(公告)日：2021-02-25

申请号：US16613191

申请日：2018-05-15

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Yohei TAKATA ,  Yoshiyuki SHIMIZU ,  Tsuyoshi KOSUGI ,  Hiroyuki OKADA

IPC: A61B18/24

Abstract: A catheter kit includes a catheter having an optical fiber, and a catheter accommodating tool which accommodates the catheter. The catheter accommodating tool has a tubular hoop, and a protection cap which is provided to the hoop. The protection cap has a transmission window through which laser light L output from the catheter passes.

公开(公告)号：US20200170706A1

公开(公告)日：2020-06-04

申请号：US16613239

申请日：2018-05-15

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Yohei TAKATA ,  Yoshiyuki SHIMIZU ,  Tsuyoshi KOSUGI ,  Hiroyuki OKADA

IPC: A61B18/24 ,  G02B6/42

Abstract: A light measurement device measures the intensity of laser light output from a catheter tip end portion of a catheter having a built-in optical fiber. The light measurement device includes a light receiving part which receives the laser light output from the catheter tip end portion and a mounting part which is disposed at a position facing the light receiving part. The mounting part defines a position of a tubular hoop, which accommodates the catheter, with respect to the light receiving part. In a state in which the position of the hoop is defined by the mounting part, the light measurement device obtains the intensity of the laser light by inputting the laser light to the light receiving part.

公开(公告)号：US20200170705A1

公开(公告)日：2020-06-04

申请号：US16613197

申请日：2018-05-15

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Yohei TAKATA ,  Yoshiyuki SHIMIZU ,  Tsuyoshi KOSUGI ,  Hiroyuki OKADA

IPC: A61B18/24 ,  A61M25/00

Abstract: A catheter kit includes a catheter having an optical fiber, and a catheter accommodating tool which accommodates the catheter. The catheter accommodating tool has a tubular hoop, and a position adjustment mechanism provided at the hoop. The hoop has a hoop tip end portion at which a catheter tip end portion from which laser light transmitted through the optical fiber is emitted is disposed, and a hoop base end portion which is opposite to the hoop tip end portion. The position adjustment mechanism is provided at the hoop base end portion and changes a position of the catheter tip end portion with respect to the hoop tip end portion.

公开(公告)号：US20190056324A1

公开(公告)日：2019-02-21

申请号：US15763935

申请日：2016-09-08

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Akinori ODA ,  Hiroshi SATOZONO ,  Tomomi SHINKE ,  Yohei TAKATA

IPC: G01N21/64 ,  G01N33/68

Abstract: The present invention relates to a method for detecting an amyloid β oligomer which includes a test sample and thioflavin T are brought into contact with each other, fluorescence of the thioflavin T is measured to obtain time-resolved fluorescence spectra, the time-resolved fluorescence spectrum of time period t1 to t2 and the time-resolved fluorescence spectrum of time period t3 to t4 are respectively normalized to obtain normalized spectra (t1