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公开(公告)号：US09643972B2
公开(公告)日：2017-05-09
申请号：US14933863
申请日：2015-11-05
发明人： Hilary Plake Beck , Juan Carlos Jaen , Maksim Osipov , Jay Patrick Powers , Maureen Kay Reilly , Hunter Paul Shunatona , James Ross Walker , Mikhail Zibinsky , James Aaron Balog , David K. Williams , Jay A. Markwalder , Emily Charlotte Cherney , Weifang Shan , Audris Huang
IPC分类号： A61K31/4709 , C07D487/04 , C07D215/06 , A61K31/47 , C07D231/56 , A61K31/416 , C07D215/233 , C07D471/04 , A61K31/437 , C07D239/74 , A61K31/517 , A61K31/4375 , C07D217/04 , C07D405/08 , C07D417/08 , C07D401/12 , C07D401/14 , A61K31/506 , A61K31/496 , A61K31/519 , A61K45/06
CPC分类号： C07D487/04 , A61K31/416 , A61K31/437 , A61K31/4375 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/517 , A61K31/519 , A61K45/06 , C07D215/06 , C07D215/14 , C07D215/233 , C07D217/04 , C07D231/56 , C07D239/74 , C07D401/12 , C07D401/14 , C07D405/08 , C07D405/12 , C07D417/08 , C07D417/12 , C07D471/04
摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
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公开(公告)号：US10987322B2
公开(公告)日：2021-04-27
申请号：US15315071
申请日：2015-06-05
发明人： Juan Carlos Jaen , Maksim Osipov , Jay Patrick Powers , Hunter Paul Shunatona , James Ross Walker , Mikhail Zibinsky
IPC分类号： A61K31/15 , C07D295/155 , C07D213/58 , C07D307/16 , A61K45/06 , C07C259/12 , C07D211/62 , C07D277/56 , A61K31/4409 , A61K31/167 , A61K31/196 , A61K31/24 , A61K31/27 , A61K31/341 , A61K31/40 , A61K31/426 , A61K31/4402 , A61K31/445 , A61K31/5375 , C07C259/14 , C07C271/28 , C07D207/09 , C07D211/34 , C07D277/30
摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
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公开(公告)号：US10533014B2
公开(公告)日：2020-01-14
申请号：US16123912
申请日：2018-09-06
发明人： Hilary Plake Beck , Juan Carlos Jaen , Maksim Osipov , Jay Patrick Powers , Maureen Kay Reilly , Hunter Paul Shunatona , James Ross Walker , Mikhail Zibinsky , James Aaron Balog , David K. Williams , Jay A. Markwalder , Emily Charlotte Cherney , Weifang Shan , Audris Huang
IPC分类号： C07D487/04 , A61K31/47 , C07D215/06 , C07D231/56 , A61K31/416 , C07D215/233 , C07D471/04 , A61K31/437 , C07D239/74 , A61K31/517 , A61K31/4375 , C07D217/04 , C07D405/08 , A61K31/4709 , C07D417/08 , C07D401/12 , C07D401/14 , A61K31/506 , A61K31/496 , A61K31/519 , A61K45/06 , C07D215/14 , C07D405/12 , C07D417/12 , A61P35/02 , C07D215/12 , C07D217/12 , C07D217/24 , A61K39/395
摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
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公开(公告)号：US09598422B2
公开(公告)日：2017-03-21
申请号：US14933879
申请日：2015-11-05
发明人： Hilary Plake Beck , Juan Carlos Jaen , Maksim Osipov , Jay Patrick Powers , Maureen Kay Reilly , Hunter Paul Shunatona , James Ross Walker , Mikhail Zibinsky , James Aaron Balog , David K. Williams , Jay A. Markwalder , Steven P. Seitz , Emily Charlotte Cherney , Liping Zhang , Weifang Shan , Weiwei Guo , Audris Huang
IPC分类号： C07C255/50 , A61K31/277 , C07C233/65 , C07D487/04 , A61K31/166 , C07D211/08 , A61K31/445 , C07C211/45 , A61K31/136 , C07D215/04 , A61K31/47 , A61K31/4709 , C07D215/233 , C07D213/68 , A61K31/4412 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K45/06 , A61K31/00
CPC分类号： A61K31/166 , A61K31/00 , A61K31/136 , A61K31/277 , A61K31/4412 , A61K31/445 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07C211/45 , C07C217/80 , C07C233/10 , C07C233/59 , C07C233/60 , C07C233/65 , C07C233/74 , C07C255/50 , C07C255/58 , C07C275/30 , C07C2601/14 , C07D211/08 , C07D213/68 , C07D215/04 , C07D215/233 , C07D487/04
摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
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公开(公告)号：US11242319B2
公开(公告)日：2022-02-08
申请号：US15524113
申请日：2015-11-05
发明人： Hilary Plake Beck , Juan Carlos Jaen , Maksim Osipov , Jay Patrick Powers , Maureen Kay Reilly , Hunter Paul Shunatona , James Ross Walker , Mikhail Zibinsky , James Aaron Balog , David K. Williams , Weiwei Guo
IPC分类号： C07D213/75 , A61K45/06 , A61K31/167 , C07C255/60 , C07C317/40 , C07D239/42 , C07C233/15 , C07D295/155 , C07C233/29 , C07C237/22 , C07C233/66 , C07D213/56 , C07C321/28 , C07D295/15 , C07C235/26 , A61K31/195 , C07C255/57 , C07C235/38 , C07D207/27 , C07D231/12 , C07C317/44 , C07C237/20 , C07D309/06 , C07D309/04 , C07C235/36 , C07D317/46 , C07D277/30 , A61K31/426 , A61K39/39 , A61P35/00 , A61P37/06 , A61K31/277 , A61K31/343 , A61K31/44 , A61K31/505 , A61K31/5375 , C07C233/11 , C07C233/28 , C07C323/41 , C07D317/66 , A61K39/00
摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
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公开(公告)号：US10106546B2
公开(公告)日：2018-10-23
申请号：US15469707
申请日：2017-03-27
发明人： Hilary Plake Beck , Juan Carlos Jaen , Maksim Osipov , Jay Patrick Powers , Maureen Kay Reilly , Hunter Paul Shunatona , James Ross Walker , Mikhail Zibinsky , James Aaron Balog , David K. Williams , Jay A. Markwalder , Emily Charlotte Cherney , Weifang Shan , Audris Huang
IPC分类号： A61K31/47 , C07D487/04 , C07D215/06 , C07D231/56 , A61K31/416 , C07D215/233 , C07D471/04 , A61K31/437 , C07D239/74 , A61K31/517 , A61K31/4375 , C07D217/04 , C07D405/08 , A61K31/4709 , C07D417/08 , C07D401/12 , C07D401/14 , A61K31/506 , A61K31/496 , A61K31/519 , A61K45/06 , C07D215/14 , C07D405/12 , C07D417/12
摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
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公开(公告)号：US20170197973A1
公开(公告)日：2017-07-13
申请号：US15469707
申请日：2017-03-27
发明人： Hilary Plake Beck , Juan Carlos Jaen , Maksim Osipov , Jay Patrick Powers , Maureen Kay Reilly , Hunter Paul Shunatona , James Ross Walker , Mikhail Zibinsky , James Aaron Balog , David K. Williams , Jay A. Markwalder , Emily Charlotte Cherney , Weifang Shan , Audris Huang
IPC分类号： C07D487/04 , C07D215/14 , A61K31/416 , C07D231/56 , A61K45/06 , C07D215/233 , C07D471/04 , A61K31/437 , A61K31/517 , C07D239/74 , A61K31/4375 , A61K31/4709 , C07D405/12 , C07D401/12 , C07D417/12 , A61K31/496 , C07D401/14 , A61K31/519 , A61K31/506 , A61K31/47
CPC分类号： C07D215/12 , A61K31/416 , A61K31/437 , A61K31/4375 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/517 , A61K31/519 , A61K39/39558 , A61K45/06 , A61K2300/00 , A61P35/02 , C07D215/06 , C07D215/14 , C07D215/233 , C07D217/04 , C07D217/12 , C07D217/24 , C07D231/56 , C07D239/74 , C07D401/12 , C07D401/14 , C07D405/08 , C07D405/12 , C07D417/08 , C07D417/12 , C07D471/04 , C07D487/04
摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
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公开(公告)号：US10206893B2
公开(公告)日：2019-02-19
申请号：US15422118
申请日：2017-02-01
发明人： Hilary Plake Beck , Juan Carlos Jaen , Maksim Osipov , Jay Patrick Powers , Maureen Kay Reilly , Hunter Paul Shunatona , James Ross Walker , Mikhail Zibinsky , James Aaron Balog , David K. Williams , Jay A. Markwalder , Steven P. Seitz , Emily Charlotte Cherney , Liping Zhang , Weifang Shan , Weiwei Guo , Audris Huang
IPC分类号： A61K31/166 , A61K31/5377 , A61K31/497 , A61K31/506 , A61K45/06 , A61K31/4709 , C07D487/04 , C07C255/50 , A61K31/277 , C07C233/65 , C07D211/08 , A61K31/445 , C07C211/45 , A61K31/136 , C07D215/04 , A61K31/47 , C07D215/233 , C07D213/68 , A61K31/4412 , A61K31/496 , A61K31/519 , A61K31/00 , C07C255/58 , C07C275/30 , C07C217/80 , C07C233/10 , C07C233/59 , C07C233/60 , C07C233/74
摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
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公开(公告)号：US20190002472A1
公开(公告)日：2019-01-03
申请号：US16123912
申请日：2018-09-06
发明人： Hilary Plake Beck , Juan Carlos Jaen , Maksim Osipov , Jay Patrick Powers , Maureen Kay Reilly , Hunter Paul Shunatona , James Ross Walker , Mikhail Zibinsky , James Aaron Balog , David K. Williams , Jay A. Markwalder , Emily Charlotte Cherney , Weifang Shan , Audris Huang
IPC分类号： C07D487/04 , A61K45/06 , C07D405/12 , A61K31/496 , A61K31/506 , C07D401/14 , C07D401/12 , C07D417/08 , A61K31/4709 , C07D405/08 , C07D217/04 , A61K31/4375 , A61K31/517 , C07D239/74 , A61K31/437 , C07D471/04 , C07D215/233 , A61K31/416 , C07D231/56 , A61K31/47 , C07D215/06 , C07D417/12 , C07D215/14 , A61K31/519
摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
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公开(公告)号：US20170143649A1
公开(公告)日：2017-05-25
申请号：US15422118
申请日：2017-02-01
发明人： Hilary Plake Beck , Juan Carlos Jaen , Maksim Osipov , Jay Patrick Powers , Maureen Kay Reilly , Hunter Paul Shunatona , James Ross Walker , Mikhail Zibinsky , James Aaron Balog , David K. Williams , Jay A. Markwalder , Steven P. Seitz , Emily Charlotte Cherney , Liping Zhang , Weifang Shan , Weiwei Guo , Audris Huang
IPC分类号： A61K31/166 , A61K31/5377 , A61K31/497 , A61K31/506 , A61K45/06 , A61K31/4709
CPC分类号： A61K31/47 , A61K31/00 , A61K31/136 , A61K31/166 , A61K31/277 , A61K31/381 , A61K31/4412 , A61K31/445 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , A61K2300/00 , A61P35/00 , C07C211/45 , C07C217/80 , C07C233/10 , C07C233/59 , C07C233/60 , C07C233/65 , C07C233/74 , C07C255/50 , C07C255/58 , C07C275/30 , C07C2601/14 , C07D211/08 , C07D213/68 , C07D215/04 , C07D215/233 , C07D487/04 , C07K16/18
摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
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