公开(公告)号：US20250027020A1

公开(公告)日：2025-01-23

申请号：US18714867

申请日：2022-11-17

Applicant: CORNING INCORPORATED

Inventor： Yujian Sun ,  Yue Zhou

IPC: C12M1/12 ,  C12M3/00

Abstract: A cell culture matrix for culturing cells in a fixed bed reactor is provided. The cell culture matrix includes a plurality of substrate layers in a stacked arrangement, with each layer being a substrate material with an ordered and regular array of openings passing through the layer, where the openings are separated by the substrate material, which has a physical structure that is substantially regular and uniform and that is for growing cell thereon. The plurality of substrate layers includes a first substrate material and a second substrate material that is different from the first substrate material in at least one physical dimension. The first substrate material and the second substrate material make up separate layers of the plurality of substrate layers.

公开(公告)号：US20240344008A1

公开(公告)日：2024-10-17

申请号：US18293618

申请日：2022-07-21

Applicant: CORNING INCORPORATED

Inventor： Yujian Sun ,  Yue Zhou

IPC: C12M1/12 ,  C12M1/00

CPC classification number: C12M25/18 ,  C12M29/06

Abstract: A packed-bed bioreactor system for culturing cells is provided. The system includes a cell culture vessel having at least one interior reservoir, an inlet fluidly connected to the reservoir, and an outlet fluidly connected to the reservoir; and a cell culture matrix disposed in the reservoir and arranged as a fixed bed. The cell culture matrix includes a substrate configured for adhering cells thereto. The cell culture matrix maintains a uniform flow within the reservoir throughout the cell culture matrix.

公开(公告)号：US20230173514A1

公开(公告)日：2023-06-08

申请号：US18072104

申请日：2022-11-30

Applicant: CORNING INCORPORATED

Inventor： James Michael Brown ,  Brian Charles Cook ,  Daniel Warren Hawtof ,  Purushotam Kumar ,  Sean Thomas Miller ,  Bruce Arthur Mourhess, JR. ,  Elias Panides ,  James Westley Rogacki ,  John Stone, III ,  Yujian Sun ,  Leo Young Zheng

IPC: B05B7/08 ,  B05B13/02 ,  C03C17/00

CPC classification number: B05B7/0815 ,  B05B13/0228 ,  C03C17/005 ,  C03C2218/112

Abstract: A spray coating apparatus that applies a coating material onto outer surfaces of glass objects includes a coating material source that includes a coating material. A spray nozzle assembly includes a spray nozzle fluidly connected to the coating material source. The spray nozzle is arranged and configured to direct the coating material in a first direction toward the glass object and provide an overspray amount of the coating material by the glass object such that the overspray amount bypasses a non-line of sight area of the glass object. A turn nozzle assembly includes a turn nozzle fluidly connected to a pressurized gas source. The turn nozzle is arranged and configured to direct pressurized gas in a second direction different than the first direction toward the non-line of sight area of the glass package to redirect the coating material onto the non-line of sight area.

公开(公告)号：US20240336885A1

公开(公告)日：2024-10-10

申请号：US18293676

申请日：2022-07-21

Applicant: CORNING INCORPORATED

Inventor： Yujian Sun ,  Vinalia Tjong ,  Yue Zhou

IPC: C12M1/12 ,  C12M1/00

CPC classification number: C12M25/18 ,  C12M25/02 ,  C12M29/10

Abstract: A bioreactor system for culturing cells is provided having a cell culture vessel with an interior reservoir, and an inlet and outlet connected to the reservoir. The system also includes a cell culture matrix in the reservoir for adhering cells thereto. The cell culture matrix maintains a uniform flow of liquid media through the cell culture matrix, such that the uniform flow satisfies the following expressions: wherein P is greater than or equal to at least one of 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, and 0.95, and wherein N is less than or equal to at least one of 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, and 1.0.

公开(公告)号：US20230348834A1

公开(公告)日：2023-11-02

申请号：US17779044

申请日：2020-10-30

Applicant: CORNING INCORPORATED

Inventor： Sumitava De ,  Abhijit Rao ,  Ryann Loren Russell ,  Yujian Sun

IPC: C12M1/12 ,  C12M1/08

CPC classification number: C12M25/18 ,  C12M27/24

Abstract: A packed-bed bioreactor is provided that includes: a vessel having an interior cavity defined by an outer wall; and a center column disposed within the interior cavity. The center column includes a columnar sidewall defining an inner region within the center column, the columnar sidewall separating the inner region from an outer region within the interior cavity. The bioreactor further includes a cell culture substrate disposed in the outer region of the cavity, the cell culture substrate surrounding the center column; at least one port extending through the vessel for at least one supply and removal of media to or from the interior cavity; and a fountain head element disposed above the center column.

公开(公告)号：US20220064046A1

公开(公告)日：2022-03-03

申请号：US17410131

申请日：2021-08-24

Applicant: CORNING INCORPORATED

Inventor： Purushotam Kumar ,  Sean Thomas Miller ,  Elias Panides ,  Yujian Sun

IPC: C03B17/04 ,  C03B23/00

Abstract: An enclosure for providing a controlled environment includes a central plane extending through a top end of the enclosure and a bottom end of the enclosure and bisecting the enclosure along a width of the enclosure, an inlet at the bottom end of the enclosure having an inlet width, Winlet, an enclosure wall extending from the inlet to the top end of the enclosure, an entry port at the top end of the enclosure, and an outlet between the entry port and the chamber region of the enclosure wall. The enclosure wall comprises a chamber region and a transition region between the inlet and the chamber region. The width of the chamber region, Wchamber, is substantially constant through the chamber region. The width of the enclosure in the transition region decreases from Wchamber to Winlet, and a ratio of Winlet to Wchamber is from 1:2 to 1:5.