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    PROCESS AND COMPOSITION FOR KILLING SPORES
    1.
    发明申请
    PROCESS AND COMPOSITION FOR KILLING SPORES 审中-公开
    杀戮运动的过程和组成

    公开(公告)号：US20150305343A1

    公开(公告)日：2015-10-29

    申请号：US14525497

    申请日：2014-10-28

    Applicant: American Sterilizer Company

    Inventor： Peter A. Burke ,  Mark James Leggett ,  Michael A. Centanni

    IPC: A01N59/00 ,  A01N37/16

    CPC classification number: A01N59/00 ,  A01N37/16 ,  A61K8/22 ,  A61K31/327 ,  A61K33/40 ,  A61K45/06 ,  A61Q11/00 ,  A61Q17/005 ,  A01N2300/00 ,  A61K2300/00

    Abstract: This invention relates to an aqueous composition and a process for killing spores. The process may comprise contacting the spores with the aqueous composition for a sufficient period of time to effect a desired reduction (e.g., at least a 4 log reduction) in the number of spores capable of returning to vegetative growth. The aqueous composition may comprise water, an antimicrobial agent (e.g., peracetic acid) and a peroxide (e.g., hydrogen peroxide). The process may be a two-step process involving the use of a first aqueous composition, which may comprise water and the peroxide, and a second aqueous composition which may comprise water and the antimicrobial agent.

    Abstract translation: 本发明涉及水性组合物和杀死孢子的方法。 该方法可以包括使孢子与水性组合物接触足够的时间以实现能够恢复营养生长的孢子数量的期望的还原（例如至少4log的减少）。 水性组合物可以包含水，抗微生物剂（例如过乙酸）和过氧化物（例如过氧化氢）。 该方法可以是包括使用可以包含水和过氧化物的第一含水组合物和可以包含水和抗微生物剂的第二含水组合物的两步法。

    PROCESS AND COMPOSITION FOR KILLING SPORES
    2.
    发明申请
    PROCESS AND COMPOSITION FOR KILLING SPORES 审中-公开
    杀戮运动的过程和组成

    公开(公告)号：US20150305342A1

    公开(公告)日：2015-10-29

    申请号：US14262840

    申请日：2014-04-28

    Applicant: American Sterilizer Company

    Inventor： Peter A. Burke ,  Mark James Leggett

    IPC: A01N59/00 ,  A01N37/36

    Abstract: This invention relates to a process and an aqueous composition for killing spores. The process comprises contacting the spores with the aqueous composition for a sufficient period of time to effect a desired reduction (e.g., at least a 4 log reduction) in the number of spores capable of reproduction, metabolism and/or growth. The aqueous composition comprises water, peracetic acid and hydrogen peroxide. The concentration of peracetic acid in the water may be in the range from about 0.001 to about 60% by weight, or from about 0.001 to about 0.5% by weight. The weight ratio of peracetic acid to hydrogen peroxide may be in the range from about 0.001 to about 0.5.

    Abstract translation: 本发明涉及杀死孢子的方法和含水组合物。 该方法包括使孢子与水性组合物接触足够的时间以实现能够繁殖，代谢和/或生长的孢子数量所需的还原（例如，至少4log的减少）。 含水组合物包含水，过乙酸和过氧化氢。 过乙酸在水中的浓度可以在约0.001至约60重量％，或约0.001至约0.5重量％的范围内。 过乙酸与过氧化氢的重量比可以在约0.001至约0.5的范围内。

    Biological indicator
    4.
    发明授权
    Biological indicator 有权

    公开(公告)号：US10011843B2

    公开(公告)日：2018-07-03

    申请号：US15618156

    申请日：2017-06-09

    Applicant: American Sterilizer Company

    Inventor： Phillip P. Franciskovich ,  Tricia A. Cregger ,  William A. Yirava ,  Peter A. Burke

    IPC: C12Q1/22 ,  C12Q1/34 ,  C12Q1/68 ,  C12N15/75 ,  C12M1/12 ,  C12N9/38 ,  A61L2/28 ,  C12M1/34 ,  C12Q1/6897 ,  C12Q1/689

    Abstract: This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed.

    DECONTAMINATION OR STERILIZATION PROCESS
    5.
    发明申请
    DECONTAMINATION OR STERILIZATION PROCESS 审中-公开
    去污或灭菌过程

    公开(公告)号：US20150305344A1

    公开(公告)日：2015-10-29

    申请号：US14538011

    申请日：2014-11-11

    Applicant: American Sterilizer Company

    Inventor： Peter A. Burke ,  Mark James Leggett ,  Michael A. Centanni

    IPC: A01N59/00 ,  A01N37/36

    CPC classification number: A01N59/00 ,  A61L2/202 ,  A61L2/204 ,  A61L2/208 ,  A61L2202/24 ,  A01N37/16 ,  A01N2300/00

    Abstract: This invention relates to a decontamination or sterilization process wherein spores are killed, comprising: forming droplets of an aqueous composition comprising water and a peroxide, the aqueous composition having a concentration of peroxide in the range from about 0.01 to about 14% by weight; vaporizing the droplets to form a sporicidal vaporous mixture; and contacting the spores with the sporicidal vaporous mixture for a sufficient period of time to effect at least a 4 log reduction in the number of spores capable of returning to vegetative growth.

    Abstract translation: 本发明涉及灭菌或杀菌过程，其中孢子被杀死，包括：形成包含水和过氧化物的含水组合物的液滴，所述水性组合物的浓度为约0.01至约14重量％的过氧化物; 使液滴蒸发以形成杀孢子气体混合物; 并将孢子与杀孢子气体混合物接触足够的时间以使能够恢复营养生长的孢子数至少减少4log。

    Biological indicator
    6.
    发明授权
    Biological indicator 有权

    公开(公告)号：US10301632B2

    公开(公告)日：2019-05-28

    申请号：US16001266

    申请日：2018-06-06

    Applicant: American Sterilizer Company

    Inventor： Phillip P. Franciskovich ,  Tricia A. Cregger ,  William A. Yirava ,  Peter A. Burke

    IPC: C12Q1/22 ,  C12Q1/34 ,  C12Q1/689 ,  C12Q1/6897 ,  C12Q1/68 ,  C12N15/75 ,  A61L2/28 ,  C12M1/34 ,  C12M1/12 ,  C12N9/38

    Abstract: This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed.

    Biological indicator
    8.
    发明授权
    Biological indicator 有权

    公开(公告)号：US10011844B2

    公开(公告)日：2018-07-03

    申请号：US15618157

    申请日：2017-06-09

    Applicant: American Sterilizer Company

    Inventor： Phillip P. Franciskovich ,  Tricia A. Cregger ,  William A. Yirava ,  Peter A. Burke

    IPC: C12Q1/22 ,  C12Q1/34 ,  C12Q1/68 ,  C12N15/75 ,  C12M1/12 ,  C12N9/38 ,  A61L2/28 ,  C12M1/34 ,  C12Q1/6897 ,  C12Q1/689

    Abstract: This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed.

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