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公开(公告)号：US09681972B2
公开(公告)日：2017-06-20
申请号：US14918318
申请日：2015-10-20
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Rommel Lumauig , James Oberhauser
CPC classification number: A61F2/958 , A61F2/915 , A61F2002/9522 , B23P11/005 , B23P11/025 , B29C53/02 , B29C2793/0009 , B29K2067/046 , B29K2995/006 , B29L2031/7534 , Y10T29/49865 , Y10T29/49913
Abstract: A medical device-includes a scaffold crimped to a catheter having an expansion balloon. The scaffold is crimped to the balloon by a process that includes one or more balloon pressurization steps. The balloon pressurization steps are selected to enhance scaffold retention to the balloon and maintain a relatively uniform arrangement of balloon folds about the inner surface of the crimped scaffold so that the scaffold expands in a uniform manner when the balloon is inflated.
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公开(公告)号：US09681971B2
公开(公告)日：2017-06-20
申请号：US14867919
申请日：2015-09-28
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang
IPC: B23P11/02 , A61F2/06 , A61F2/958 , A61L31/06 , A61L31/16 , A61M25/10 , B29D23/00 , A61F2/95 , B29K67/00
CPC classification number: A61F2/958 , A61F2002/9522 , A61F2240/001 , A61L31/06 , A61L31/16 , A61M25/1034 , B23P11/025 , B29D23/00 , B29K2067/043 , B29K2067/046 , B29K2995/0082 , Y10T29/49865 , Y10T29/49913 , Y10T29/49925 , Y10T29/49927 , Y10T29/49929 , C08L67/04
Abstract: A medical device-includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold is crimped to the balloon by a process that includes inflating the delivery balloon during a diameter reduction to improve scaffold retention. A crimping temperature is maintained at about the onset of glass transition of the polymer material to facilitate more rapid stabilization of mechanical properties in the scaffold following crimping.
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公开(公告)号：US20170028616A1
公开(公告)日：2017-02-02
申请号：US15225720
申请日：2016-08-01
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Kevin F. Jow , Arlene Sucy Yang, JR. , Yunbing Wang , Kathleen W. Yan
CPC classification number: B29C65/72 , A61F2/89 , A61F2/915 , A61F2/958 , A61F2002/825 , A61F2002/91575 , A61F2210/0004 , A61F2210/0061 , B29C47/0004 , B29C47/0023 , B29C65/02 , B29C65/565 , B29C66/534 , B29K2067/046 , B29K2105/0085 , B29K2995/0056 , B29L2031/7532 , B29L2031/7543 , Y10T29/49863 , Y10T29/49865 , Y10T29/49913 , Y10T29/49925 , Y10T29/49927 , Y10T29/49929 , Y10T156/1005
Abstract: A medical device-includes a polymer stent crimped to a catheter having an expansion balloon. The stent is crimped to the balloon by a process that includes heating the stent to a temperature below the polymer's glass transition temperature to improve stent retention without adversely affecting the mechanical characteristics of the stent when later deployed to support a body lumen.
Abstract translation: 一种医疗装置 - 包括卷曲到具有膨胀气囊的导管的聚合物支架。 将支架通过包括将支架加热到低于聚合物玻璃化转变温度的温度的方法来卷曲到气囊，以改善支架保持，而不会在稍后部署以支撑体腔时对支架的机械特性产生不利影响。
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公开(公告)号：US20160296676A1
公开(公告)日：2016-10-13
申请号：US15188698
申请日：2016-06-21
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Derek Mortisen , Yunbing Wang
CPC classification number: A61L31/06 , A61F2/915 , A61F2002/91575 , A61F2002/91583 , A61F2210/0004 , A61F2230/0054 , A61F2230/0056 , A61F2250/0067 , A61K31/737 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/42 , C08L67/04
Abstract: Bioabsorbable polymer scaffolds with coatings are disclosed that include immobilized antithrombotic agents on the scaffolds or in or on the coatings. The agents act synergistically with antiproliferative agents released from coatings by providing hemocompatibility during and without interfering with antiproliferative agent release. Methods of modifying scaffolds and coatings with the antithrombotic agents are disclosed.
Abstract translation: 公开了具有涂层的生物可吸收聚合物支架，其包括在支架上或涂层中或涂层上的固定化抗血栓形成剂。 与抗增殖剂释放期间和之间提供血液相容性，这些试剂与从涂层释放的抗增殖剂协同作用。 公开了用抗血栓形成剂修饰支架和涂层的方法。
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公开(公告)号：US09278485B2
公开(公告)日：2016-03-08
申请号：US13736864
申请日：2013-01-08
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： David C. Gale , Yunbing Wang , Svava Maria Atladottir , Klaus Kleine
IPC: B29C71/04 , B23K26/38 , B29C53/82 , B29C33/42 , B29C67/00 , B26D3/16 , B29C59/16 , B23K26/08 , B23K26/40 , A61F2/91 , B29C59/02
CPC classification number: B29C59/165 , A61F2/91 , A61F2240/001 , B23K26/0823 , B23K26/38 , B23K26/402 , B23K2103/42 , B23K2103/50 , B26D3/164 , B29C33/42 , B29C53/82 , B29C67/0022 , B29C71/04 , B29C2059/027 , B29C2791/009 , B29C2793/0018 , B29K2005/00 , B29L2031/7546
Abstract: Apparatus, method and system for cutting a polymeric stent including the use of a polymeric mandrel as a laser shielding device. The polymeric mandrel is allowed to roll freely within a polymeric tube that is cut into a polymeric stent.
Abstract translation: 用于切割聚合物支架的装置，方法和系统，包括使用聚合物心轴作为激光屏蔽装置。 允许聚合物心轴在切割成聚合物支架的聚合物管内自由滚动。
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Patent Agency Ranking
6.发明授权Method to minimize molecular weight drop of poly(L-lactide) stent during processing 有权减少加工过程中聚（L-丙交酯）支架分子量下降的方法公开(公告)号：US09278470B2
公开(公告)日：2016-03-08
申请号：US14530151
申请日：2014-10-31
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Byron Lambert , Yunbing Wang , James Oberhauser
IPC: A61L31/06 , B29C47/00 , A61L31/04 , A61L31/14 , C08J3/28 , A61F2/82 , B29D23/20 , B29L23/20 , B29L31/00
CPC classification number: B29C47/0076 , A61F2/82 , A61L31/041 , A61L31/06 , A61L31/143 , A61L31/148 , B29D23/20 , B29K2005/00 , B29L2023/20 , B29L2031/753 , C08J3/28 , C08J2367/04 , C08L67/04
Abstract: A method to reduce or minimize the reduction in molecular weight of a stent during processing is disclosed. The stent has a scaffolding including a polymer formulation comprising PLLA and polymandelide. The polymandelide reduces the molecular weight drop during processing, particularly during sterilization. The stent scaffolding can further include one or more additional stabilizing agents that additionally reduce the molecular weight drop during processing.
Abstract translation: 公开了减少或最小化处理期间支架分子量降低的方法。 支架具有包括PLLA和聚扁桃酸酯的聚合物制剂的脚手架。 聚对苯二甲酸丁二醇酯降低加工过程中的分子量下降，特别是在灭菌过程中。 支架支架还可包括一种或多种附加的稳定剂，其另外降低加工过程中的分子量下降。
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7.发明授权Polymer-bioceramic composite implantable medical device with different types of bioceramic particles 有权具有不同类型生物陶瓷颗粒的聚合物 - 生物陶瓷复合植入式医疗装置公开(公告)号：US09199004B2
公开(公告)日：2015-12-01
申请号：US13933071
申请日：2013-07-01
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , David C. Gale , Syed F. A. Hossainy
Abstract: Implantable medical devices fabricated from polymer/bioceramic composites with different types of bioceramic particles are disclosed.
Abstract translation: 公开了由具有不同类型的生物陶瓷颗粒的聚合物/生物陶瓷复合材料制成的植入式医疗装置。
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8.发明授权Polyester implantable medical device with controlled in vivo biodegradability 有权具有受体内生物降解性的聚酯可植入医疗器械公开(公告)号：US09186440B2
公开(公告)日：2015-11-17
申请号：US14456739
申请日：2014-08-11
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang
CPC classification number: A61L31/041 , A61K9/0024 , A61K9/1647 , A61L27/26 , A61L31/148 , C08L67/04
Abstract: This invention relates to blends of high, optionally medium, and low molecular weight polyesters where at least the low molecular weight polyester is substituted with an acidic moiety, the biodegradation of the blends being controllable by selection of the mean molecular weigh of each fraction, the quantity of each fraction in the blend and the amount and pKa of the acidic moiety(ies).
Abstract translation: 本发明涉及高，任选中等和低分子量聚酯的共混物，其中至少低分子量聚酯被酸性部分取代，共混物的生物降解可通过选择各部分的平均分子量来控制， 共混物中每个级分的量和酸性部分的量和pKa。
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公开(公告)号：US20150217509A1
公开(公告)日：2015-08-06
申请号：US14686677
申请日：2015-04-14
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Kevin F. Jow , Arlene Sucy Yang , Yunbing Wang , Kathleen W. Yan
CPC classification number: B29C65/72 , A61F2/89 , A61F2/915 , A61F2/958 , A61F2002/825 , A61F2002/91575 , A61F2210/0004 , A61F2210/0061 , B29C47/0004 , B29C47/0023 , B29C65/02 , B29C65/565 , B29C66/534 , B29K2067/046 , B29K2105/0085 , B29K2995/0056 , B29L2031/7532 , B29L2031/7543 , Y10T29/49863 , Y10T29/49865 , Y10T29/49913 , Y10T29/49925 , Y10T29/49927 , Y10T29/49929 , Y10T156/1005
Abstract: A medical device-includes a polymer stent crimped to a catheter having an expansion balloon. The stent is crimped to the balloon by a process that includes heating the stent to a temperature below the polymer's glass transition temperature to improve stent retention without adversely affecting the mechanical characteristics of the stent when later deployed to support a body lumen.
Abstract translation: 一种医疗装置 - 包括卷曲到具有膨胀气囊的导管的聚合物支架。 将支架通过包括将支架加热到低于聚合物玻璃化转变温度的温度的方法来卷曲到气囊，以改善支架保持，而不会在稍后部署以支撑体腔时对支架的机械特性产生不利影响。
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10.发明授权Sheaths reducing recoil and loss of retention for polymer scaffolds crimped to balloons 有权护套减少聚合物支架的后坐力和失去保留力，卷曲到气球公开(公告)号：US09072590B2
公开(公告)日：2015-07-07
申请号：US13708638
申请日：2012-12-07
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Jhoan Bayogo
CPC classification number: A61F2/0095 , A61F2/958 , A61F2/962 , A61F2/97 , A61F2002/011 , A61F2002/9522 , A61F2002/9583 , A61F2240/001 , A61F2250/0059 , B23P11/005 , Y10T29/49826 , Y10T29/49838 , Y10T29/49909 , Y10T29/49915
Abstract: A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. A single piece sheath is placed over the scaffold immediately following crimping of the scaffold to the balloon. The single piece sheath is replaced by a two-piece sheath, which is removed prior to performing a medical procedure using the medical device.
Abstract translation: 医疗装置包括压接到具有膨胀气囊的导管的聚合物构架。 在将支架压合到气囊之后立即将单件护套放置在支架上方。 单件护套由两件式护套代替，其在使用医疗装置执行医疗程序之前被移除。
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