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1.发明授权公开(公告)号：US08929990B2
公开(公告)日：2015-01-06
申请号：US12968831
申请日：2010-12-15
申请人： Julia Moffitt , Imad Libbus
发明人： Julia Moffitt , Imad Libbus
CPC分类号： A61N1/37288 , A61M31/00 , A61N1/0558 , A61N1/056 , A61N1/36053 , A61N1/3611 , A61N1/36114 , A61N1/36117 , A61N1/362 , A61N1/3627 , A61N1/37217
摘要： This document discusses, among other things, apparatus, systems, and methods for transvascularly stimulation of a nerve or nerve trunk. In an example, an apparatus is configured to transvascularly stimulate a nerve trunk through a blood vessel. The apparatus includes an expandable electrode that is chronically implantable in a blood vessel proximate a nerve trunk. The expandable electrode is configured to abut a predetermined surface area of the vessel wall along a predetermined length of the vessel. An electrical lead is coupled to the expandable electrode. An implantable pulse generator is coupled to the lead and configured to deliver an electrical stimulation signal to the electrode through the lead. In an example method, an electrical signal is delivered from an implanted medical device to an electrode chronically implanted in a blood vessel proximate a nerve trunk to transvascularly deliver neural stimulation from the electrode to the nerve trunk.
摘要翻译： 本文件还讨论了用于神经或神经干的经血管刺激的装置，系统和方法。 在一个实例中，一种装置构造成通过血管经血管刺激神经干。 该装置包括可长期植入在靠近神经干的血管中的可扩张电极。 可膨胀电极构造成沿容器的预定长度邻接容器壁的预定表面积。 电引线耦合到可扩张电极。 可植入脉冲发生器耦合到引线并且被配置为通过引线将电刺激信号传递到电极。 在一个示例性方法中，将电信号从植入的医疗装置输送到长期植入在靠近神经干的血管中的电极，从而将神经刺激从电极转移到神经干。
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公开(公告)号：US20130190837A1
公开(公告)日：2013-07-25
申请号：US13792805
申请日：2013-03-11
申请人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
发明人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
IPC分类号： A61N1/36
CPC分类号： A61N1/36117 , A61N1/08 , A61N1/36171
摘要： Various aspects of the present subject matter provide a device. In various embodiments, the device comprises a port adapted to connect a lead, a pulse generator connected to the port and adapted to provide a neural stimulation signal to the lead, and a signal processing module connected to the port and adapted to receive and process a nerve traffic signal from the lead into a signal indicative of the nerve traffic. The device includes a controller connected to the pulse generator and the signal processing module. The controller is adapted to implement a stimulation protocol to provide the neural stimulation signal with desired neural stimulation parameters based on the signal indicative of the nerve traffic. Other aspects are provided herein.
摘要翻译： 本主题的各个方面提供了一种装置。 在各种实施例中，该装置包括适于连接引线的端口，连接到端口的脉冲发生器，并适于向引线提供神经刺激信号，以及信号处理模块，连接到端口并适于接收和处理 神经交通信号从引导到指示神经交通的信号。 该装置包括连接到脉冲发生器和信号处理模块的控制器。 控制器适于实现刺激方案，以基于指示神经交通的信号向神经刺激信号提供期望的神经刺激参数。 本文提供了其他方面。
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公开(公告)号：US20120232604A1
公开(公告)日：2012-09-13
申请号：US13473774
申请日：2012-05-17
申请人： Julia Moffitt , Andrew P. Kramer , Imad Libbus
发明人： Julia Moffitt , Andrew P. Kramer , Imad Libbus
CPC分类号： A61N1/36114 , A61B5/0464 , A61N1/0587 , A61N1/3622 , A61N1/3627 , A61N1/368 , A61N1/3684 , A61N1/3962 , A61N2001/0585
摘要： Various aspects of the present subject matter provide devices and methods to treat AV-conducted ventricular tachyarrhythmia (AVCVT). According to various embodiments of the method, an AVCVT is sensed, an IVC-LA fat pad is stimulated when the AVCVT is sensed to block AV conduction, and bradycardia support pacing is provided while the IVC-LA fat pad is stimulated. Other aspects and embodiments are provided herein.
摘要翻译： 本主题的各个方面提供了治疗AV进行性室性快速性心律失常（AVCVT）的装置和方法。 根据该方法的各种实施例，感测到AVCVT，当检测到AVCVT以阻止AV传导时刺激IVC-LA脂肪垫，并且在IVC-LA脂肪垫被刺激的同时提供心动过缓支持起搏。 本文提供了其它方面和实施例。
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公开(公告)号：US20110082537A1
公开(公告)日：2011-04-07
申请号：US12968831
申请日：2010-12-15
申请人： Julia Moffitt , Imad Libbus
发明人： Julia Moffitt , Imad Libbus
CPC分类号： A61N1/37288 , A61M31/00 , A61N1/0558 , A61N1/056 , A61N1/36053 , A61N1/3611 , A61N1/36114 , A61N1/36117 , A61N1/362 , A61N1/3627 , A61N1/37217
摘要： This document discusses, among other things, apparatus, systems, and methods for transvascularly stimulation of a nerve or nerve trunk. In an example, an apparatus is configured to transvascularly stimulate a nerve trunk through a blood vessel. The apparatus includes an expandable electrode that is chronically implantable in a blood vessel proximate a nerve trunk. The expandable electrode is configured to abut a predetermined surface area of the vessel wall along a predetermined length of the vessel. An electrical lead is coupled to the expandable electrode. An implantable pulse generator is coupled to the lead and configured to deliver an electrical stimulation signal to the electrode through the lead. In an example method, an electrical signal is delivered from an implanted medical device to an electrode chronically implanted in a blood vessel proximate a nerve trunk to transvascularly deliver neural stimulation from the electrode to the nerve trunk.
摘要翻译： 本文件还讨论了用于神经或神经干的经血管刺激的装置，系统和方法。 在一个实例中，一种装置构造成通过血管经血管刺激神经干。 该装置包括可长期植入在靠近神经干的血管中的可扩张电极。 可膨胀电极构造成沿容器的预定长度邻接容器壁的预定表面积。 电引线耦合到可扩张电极。 可植入脉冲发生器耦合到引线并且被配置为通过引线将电刺激信号传递到电极。 在一个示例性方法中，将电信号从植入的医疗装置输送到长期植入在靠近神经干的血管中的电极，从而将神经刺激从电极转移到神经干。
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5.发明授权Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device 有权通过可植入心脏装置的联合重塑控制治疗和抗重塑治疗公开(公告)号：US07805193B2
公开(公告)日：2010-09-28
申请号：US11777394
申请日：2007-07-13
IPC分类号： A61N1/368
CPC分类号： A61N1/362 , A61N1/36114 , A61N1/3627
摘要： A method and device for delivering ventricular resynchronization pacing therapy in conjunction with electrical stimulation of nerves which alter the activity of the autonomic nervous system is disclosed. Such therapies may be delivered by an implantable device and are useful in preventing the deleterious ventricular remodeling which occurs as a result of a heart attack or heart failure. The device may perform an assessment of cardiac function in order to individually modulate the delivery of the two types of therapy.
摘要翻译： 公开了一种用于将脑室再同步起搏治疗与神经改变自主神经系统的活动的电刺激结合的方法和装置。 这样的治疗可以由可植入装置递送，并且可用于防止由于心脏病发作或心力衰竭而发生的有害心室重构。 该装置可以执行心脏功能的评估，以便单独地调节两种类型的治疗的递送。
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公开(公告)号：US07769446B2
公开(公告)日：2010-08-03
申请号：US11077583
申请日：2005-03-11
申请人： Julia Moffitt , Imad Libbus
发明人： Julia Moffitt , Imad Libbus
IPC分类号： A61N1/08
CPC分类号： A61N1/36114 , A61N1/0551 , A61N1/056 , A61N1/0587 , A61N1/36135 , A61N1/36514 , A61N1/3962 , A61N1/3987
摘要： Various aspects relate to a device which, in various embodiments, comprises a header, a neural stimulator, a detector and a controller. The header includes at least one port to connect to at least one lead, and includes first and second channels for use to provide neural stimulation to first and second neural stimulation sites for a heart. The controller is connected to the detector and the neural stimulator to selectively deliver a therapy based on the feedback signal. A first therapy signal is delivered to the first neural stimulation site to selectively control contractility and a second therapy signal is delivered to the second neural stimulation site to selectively control one of a sinus rate and an AV conduction. Other aspects and embodiments are provided herein.
摘要翻译： 各种方面涉及在各种实施例中包括头部，神经刺激器，检测器和控制器的装置。 头部包括至少一个连接至少一个引线的端口，并且包括用于向心脏的第一和第二神经刺激部位提供神经刺激的第一和第二通道。 控制器连接到检测器和神经刺激器，以基于反馈信号选择性地递送治疗。 第一治疗信号被递送到第一神经刺激部位以选择性地控制收缩性，并且第二治疗信号被递送到第二神经刺激部位以选择性地控制窦速率和AV传导之一。 本文提供了其它方面和实施例。
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公开(公告)号：US20090149900A1
公开(公告)日：2009-06-11
申请号：US12371153
申请日：2009-02-13
申请人： Julia Moffitt , Imad Libbus
发明人： Julia Moffitt , Imad Libbus
IPC分类号： A61N1/36
CPC分类号： A61N1/37288 , A61M31/00 , A61N1/0558 , A61N1/056 , A61N1/36053 , A61N1/3611 , A61N1/36114 , A61N1/36117 , A61N1/362 , A61N1/3627 , A61N1/37217
摘要： This document discusses, among other things, apparatus, systems, and methods for transvascularly stimulation of a nerve or nerve trunk. In an example, an apparatus is configured to transvascularly stimulate a nerve trunk through a blood vessel. The apparatus includes an expandable electrode that is chronically implantable in a blood vessel proximate a nerve trunk. The expandable electrode is configured to abut a predetermined surface area of the vessel wall along a predetermined length of the vessel. An electrical lead is coupled to the expandable electrode. An implantable pulse generator is coupled to the lead and configured to deliver an electrical stimulation signal to the electrode through the lead. In an example method, an electrical signal is delivered from an implanted medical device to an electrode chronically implanted in a blood vessel proximate a nerve trunk to transvascularly deliver neural stimulation from the electrode to the nerve trunk.
摘要翻译： 本文件还讨论了用于神经或神经干的经血管刺激的装置，系统和方法。 在一个实例中，一种装置构造成通过血管经血管刺激神经干。 该装置包括可长期植入在靠近神经干的血管中的可扩张电极。 可膨胀电极构造成沿容器的预定长度邻接容器壁的预定表面积。 电引线耦合到可扩张电极。 可植入脉冲发生器耦合到引线并且被配置为通过引线将电刺激信号传递到电极。 在一个示例性方法中，将电信号从植入的医疗装置输送到长期植入在靠近神经干的血管中的电极，从而将神经刺激从电极转移到神经干。
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公开(公告)号：US20060259107A1
公开(公告)日：2006-11-16
申请号：US11130022
申请日：2005-05-16
申请人： Anthony Caparso , Julia Moffitt , Avram Scheiner
发明人： Anthony Caparso , Julia Moffitt , Avram Scheiner
IPC分类号： A61N1/05
CPC分类号： A61N1/0551 , A61N1/057 , A61N1/372
摘要： A system for selective activation of a nerve trunk using a transvascular reshaping lead is provided. One aspect of this disclosure relates to a system for spreading nerve bundles in a nerve trunk. The system includes a lead adapted to be chronically implanted in a blood vessel proximate a nerve trunk, and having an expandable portion adapted to be expanded to reshape the blood vessel to an elongated shape and to reshape the nerve trunk into an elongated shape to spread nerve bundles of the nerve trunk. The system also includes a plurality of electrodes and an implantable device coupled to the lead, where an electrical signal is delivered from the implanted medical device to one of the plurality of electrodes to transvascularly deliver neural stimulation from the electrode to at least one of the nerve bundles of the nerve trunk. Other aspects and embodiments are provided herein.
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公开(公告)号：US20060106429A1
公开(公告)日：2006-05-18
申请号：US10992319
申请日：2004-11-18
申请人： Imad Libbus , Andrew Kramer , Julia Moffitt
发明人： Imad Libbus , Andrew Kramer , Julia Moffitt
IPC分类号： A61N1/18
CPC分类号： A61N1/36117 , A61N1/08 , A61N1/36171
摘要： Various aspects of the present subject matter provide a device. In various embodiments, the device comprises a port adapted to connect a lead, a pulse generator connected to the port and adapted to provide a neural stimulation signal to the lead, and a signal processing module connected to the port and adapted to receive and process a nerve traffic signal from the lead into a signal indicative of the nerve traffic. The device includes a controller connected to the pulse generator and the signal processing module. The controller is adapted to implement a stimulation protocol to provide the neural stimulation signal with desired neural stimulation parameters based on the signal indicative of the nerve traffic. Other aspects are provided herein.
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公开(公告)号：US08909337B2
公开(公告)日：2014-12-09
申请号：US13473774
申请日：2012-05-17
申请人： Julia Moffitt , Andrew P. Kramer , Imad Libbus
发明人： Julia Moffitt , Andrew P. Kramer , Imad Libbus
CPC分类号： A61N1/36114 , A61B5/0464 , A61N1/0587 , A61N1/3622 , A61N1/3627 , A61N1/368 , A61N1/3684 , A61N1/3962 , A61N2001/0585
摘要： Various aspects of the present subject matter provide devices and methods to treat AV-conducted ventricular tachyarrhythmia (AVCVT). According to various embodiments of the method, an AVCVT is sensed, an IVC-LA fat pad is stimulated when the AVCVT is sensed to block AV conduction, and bradycardia support pacing is provided while the IVC-LA fat pad is stimulated. Other aspects and embodiments are provided herein.
摘要翻译： 本主题的各个方面提供了治疗AV进行性室性快速性心律失常（AVCVT）的装置和方法。 根据该方法的各种实施例，感测到AVCVT，当检测到AVCVT以阻止AV传导时刺激IVC-LA脂肪垫，并且在IVC-LA脂肪垫被刺激的同时提供心动过缓支持起搏。 本文提供了其它方面和实施例。
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