公开(公告)号：US07280875B1

公开(公告)日：2007-10-09

申请号：US10773136

申请日：2004-02-04

申请人： Yougandh Chitre ,  John R. Helland ,  Steven R. Conger

发明人： Yougandh Chitre ,  John R. Helland ,  Steven R. Conger

IPC分类号： A61N1/05

CPC分类号： A61N1/0563 ,  Y10T29/49117

摘要： For use in an implantable medical device, there is provided a biocompatible, biostable, corrosion-resistant wire strand comprising a core comprising a plurality of electrically conductive, low electrical resistance filaments embedded in an electrically conductive matrix, and a low electrical resistance, substantially chemically inactive cladding.

摘要翻译： 为了在可植入医疗装置中使用，提供了生物相容性，生物稳定的耐腐蚀线材，其包括芯，其包含嵌入导电基体中的多个导电的，低电阻的细丝，以及基本上化学上的低电阻 不活动包层

公开(公告)号：US07027852B2

公开(公告)日：2006-04-11

申请号：US10153848

申请日：2002-05-21

申请人： John R. Helland

发明人： John R. Helland

IPC分类号： A61B5/042 ,  A61N1/05

CPC分类号： A61N1/0573 ,  A61N1/056

摘要： An body implantable stimulation lead is provided including tip electrode patterns and configurations producing low noise, clean sensed signals devoid of far field components, such sensed signals being generated irrespective of the direction of the incident depolarization wavefront. The invention also provides high pacing impedances and advantageous anode-to-cathode surface area ratios. Further, implantable leads utilizing the features of the present invention are particularly suitable for left side stimulation therapies.

摘要翻译： 提供了一种可植入人体的刺激引线，包括尖端电极图案和产生低噪声干净感测信号的结构，没有远场分量，这种感测信号不管入射去极化波前的方向而产生。 本发明还提供高起搏阻抗和有利的阳极至阴极表面积比。 此外，利用本发明的特征的可植入引线特别适用于左侧刺激疗法。

公开(公告)号：US06968237B2

公开(公告)日：2005-11-22

申请号：US10154893

申请日：2002-05-22

申请人： Phong D. Doan ,  Kevin L. Morgan ,  John R. Helland ,  Sheldon Williams ,  Kerwyn Schimke ,  Christopher R. Jenney

发明人： Phong D. Doan ,  Kevin L. Morgan ,  John R. Helland ,  Sheldon Williams ,  Kerwyn Schimke ,  Christopher R. Jenney

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N2001/0585

摘要： An implantable stimulation lead is disclosed for placement in the coronary sinus region and its associated coronary vessels overlying the left side of a patient's heart. The lead comprises at least one proximal connector; at least one tissue stimulation electrode; at least one conductor coupled between the at least one proximal connector and the at least one stimulation electrode; and a lead body including a housing of insulating material enclosing the at least one conductor, the lead body having a relatively flexible distal portion of, for example, silicone rubber, having a length corresponding to the coronary sinus region of the heart, and a stiffer proximal portion of, for example, polyurethane. A robust transition joint comprising telescoped sections of the distal and proximal portions of the lead body couples the two portions of the lead body.Also provided is a versatile lead delivery system including a stylet stop disposed within the distal portion of the lead body. The stylet stop defines an aperture dimensioned to pass a guide wire but not the enlarged distal tip of a stylet. The lead includes a tip electrode having a longitudinally extending bore dimensioned to permit passage of the guide wire through the tip electrode.

摘要翻译： 公开了一种植入式刺激引线，用于放置在冠状窦区及其相关联的冠状动脉血管，其覆盖在患者心脏的左侧。 引线包括至少一个近端连接器; 至少一个组织刺激电极; 耦合在所述至少一个近端连接器和所述至少一个刺激电极之间的至少一个导体; 以及引线体，其包括围绕所述至少一个导体的绝缘材料的外壳，所述引线主体具有例如硅橡胶的相对柔性的远端部分，其长度对应于心脏的冠状窦区域，并且较硬 例如聚氨酯的近端部分。 包括引导体的远侧和近端部分的伸缩部分的鲁棒的过渡接头将引线体的两个部分相互连接。 还提供了一种多功能引线输送系统，其包括设置在引线主体的远端部分内的探针止动器。 探针止动器限定了通过导丝而不是通孔的扩大的远端的尺寸的孔。 引线包括具有纵向延伸的孔的尖端电极，其尺寸允许引导线通过尖端电极。

公开(公告)号：US06760619B1

公开(公告)日：2004-07-06

申请号：US09945449

申请日：2001-08-31

申请人： John R. Helland ,  Gene A. Bornzin ,  Eric Falkenberg

发明人： John R. Helland ,  Gene A. Bornzin ,  Eric Falkenberg

IPC分类号： A61N1368

CPC分类号： A61N1/3627 ,  A61N1/3684 ,  A61N1/3918 ,  A61N1/395

摘要： An implantable cardiac stimulation system senses electrical activity of all four chambers of the heart and delivers pacing and defibrillation pulses to all four chambers of the heart. The system includes a lead system consisting of first and second leads. The first lead includes a right ventricular pacing electrode, a right ventricular defibrillation electrode, and a right atrial defibrillation lead. The second lead is implantable in the coronary sinus of the heart and includes a left ventricular pacing electrode, a left ventricular defibrillation electrode, a left atrial pacing electrode, and a left atrial defibrillation electrode. A right atrial pacing electrode is carried by one of the first and second leads. The system further includes a cardiac stimulation device including a pulse generator that delivers defibrillation pulses between any combination of the defibrillation electrodes and pacing pulses to any one of the pacing electrodes and a sensing circuit that senses cardiac electrical activity with any one of the pacing electrodes.

摘要翻译： 植入式心脏刺激系统感测心脏的所有四个腔室的电活动，并将心脏起搏和除颤脉冲输送到心脏的所有四个腔室。 该系统包括由第一和第二引线组成的引导系统。 第一个引线包括右心室起搏电极，右心室除颤电极和右心房除颤引线。 第二引线可植入心脏的冠状窦内，包括左心室起搏电极，左心室除颤电极，左心房起搏电极和左心房除颤电极。 右心房起搏电极由第一和第二引线之一承载。 该系统还包括心脏刺激装置，其包括脉冲发生器，该脉冲发生器将除颤电极和起搏脉冲的任何组合之间的除颤脉冲传送到任何一个起搏电极，以及感测电路，其用任何一个起搏电极感测心脏电活动。

公开(公告)号：US06748268B1

公开(公告)日：2004-06-08

申请号：US09945079

申请日：2001-08-31

申请人： John R. Helland ,  Gene A. Bornzin ,  Eric Falkenberg

发明人： John R. Helland ,  Gene A. Bornzin ,  Eric Falkenberg

IPC分类号： A61N1368

CPC分类号： A61N1/0563 ,  A61N1/3918 ,  A61N1/395 ,  A61N2001/0585

摘要： A three lead implantable cardiac stimulation system is capable of delivering stimulation pulses to any one chamber or combination of chambers of a heart. The system includes a first lead for implant in the right ventricle and having a right ventricular defibrillation electrode, a second lead for implant in the coronary sinus and having a left ventricular defibrillation electrode, and a third lead for implant in the coronary sinus and having a left atrial defibrillation electrode. One of the leads further including a right atrial defibrillation electrode for placement in one of the right atrium and superior vena cava. The system further includes an implantable cardiac stimulation device including a programmable pulse generator that delivers defibrillation pulses to any one of the defibrillation electrodes or to any combination of the defibrillation electrodes. The leads may further provide at least one pacing electrode for each chamber of the heart and the device is programmable to provide pacing pulses to any one of the pacing electrodes.

摘要翻译： 三引线可植入心脏刺激系统能够将刺激脉冲输送到心脏的任何一个腔室或腔室的组合。 该系统包括用于植入右心室并具有右心室除颤电极的第一引线，用于在冠状窦内植入并具有左心室除颤电极的第二引线和用于植入在冠状窦中的第三引线，并具有 左心房除颤电极。 其中一个引线还包括右心房除颤电极，用于放置在右心房和上腔静脉中的一个。 该系统还包括可植入心脏刺激装置，其包括将除颤脉冲输送到除颤电极中的任何一个或除颤电极的任何组合的可编程脉冲发生器。 引线还可以为心脏的每个腔室提供至少一个起搏电极，并且该装置可编程以将起搏脉冲提供给任何一个起搏电极。

公开(公告)号：US06609027B2

公开(公告)日：2003-08-19

申请号：US09793640

申请日：2001-02-23

申请人： Mark W. Kroll ,  John R. Helland

发明人： Mark W. Kroll ,  John R. Helland

IPC分类号： A61N1368

CPC分类号： A61N1/3627 ,  A61N1/368

摘要： A cardiac stimulation device, a His Bundle lead, and an associated method for detecting a conduction signal from the His Bundle. Upon this detection, the stimulation device delivers ventricular stimulation to the right and/or left ventricles at an interval following the atrial depolarization. A sensing window is initiated following the sensing of the atrial depolarization. During the sensing windows, the His Bundle signal received through the His Bundle lead is sampled and a moving average is calculated to determine a signal peak. Detection of the His Bundle signal peak triggers ventricular stimulation, which may be delivered to the right ventricle, the left ventricle, or both ventricles.

摘要翻译： 心脏刺激装置，His束引线，以及用于检测来自His束的传导信号的相关方法。 在这种检测中，刺激装置在心房去极化之后的间隔向右心室和/或左心室递送心室刺激。 在感觉到心房去极化之后启动感测窗口。 在感测窗口期间，通过His Bundle引线接收的His Bundle信号被采样，并计算移动平均线以确定信号峰值。 His Bundle信号峰的检测触发心室刺激，可以将其传送到右心室，左心室或两个脑室。

公开(公告)号：US5628780A

公开(公告)日：1997-05-13

申请号：US387525

申请日：1995-02-13

申请人： John R. Helland ,  Hong Li

发明人： John R. Helland ,  Hong Li

IPC分类号： A61M25/02 ,  A61N1/05 ,  A61N1/00 ,  A61N1/04

CPC分类号： A61M25/02 ,  A61N1/057 ,  A61M2025/028 ,  A61M2025/0286 ,  A61N2001/0582 ,  Y10S128/26

摘要： A suture sleeve for anchoring the lead body of an implantable medical device is fabricated of a biocompatible, polymeric material to which has been added color pigment in clear contrast with the bodily tissue adjacent the sleeve. The sleeve is therefore readily visible to the naked eye to aid the physician in locating the sleeve during lead implant or lead revision. Furthermore, the tubular body may be radiopaque and, therefore, easily seen on a fluoroscope through the addition of a radiologically dense material, such as tantalum powder, to the plastic from which the sleeve is molded.

摘要翻译： 用于固定可植入医疗装置的引线体的缝合套管由生物相容的聚合物材料制成，已经与邻近套管的身体组织形成明显的颜色颜料。 因此，肉眼可以容易地看到套筒，以帮助医生在引线植入或引线修复期间定位套管。 此外，管状体可以是不透射线的，并且因此通过将放射致密材料（例如钽粉末）添加到成型套筒的塑料上而在荧光镜上容易地看到。

公开(公告)号：US5411528A

公开(公告)日：1995-05-02

申请号：US979083

申请日：1992-11-19

申请人： Leslie S. Miller ,  John R. Helland

发明人： Leslie S. Miller ,  John R. Helland

IPC分类号： A61N1/365 ,  A61N1/368 ,  A61N1/372 ,  A61N1/39 ,  A61N1/08

CPC分类号： A61N1/3956 ,  A61N1/372 ,  A61N1/3918 ,  Y10T307/839

摘要： A programmable output connector of an implantable cardioverter-defibrillator (ICD), or similar implantable medical device, allows each of a multiplicity of output terminals to be selectively connected to either a positive or a negative output bus of the ICD. The positive and negative output buses of the ICD, in turn, are switched to an output capacitor, or equivalent output circuit, of the ICD. An electrical charge stored on the output capacitor, or otherwise generated by the output circuit, is presented to the multiplicity of output terminals in accordance with a programmed polarity. The programmed polarity causes a selected one or group of the multiplicity of output terminals to be connected to the positive output bus, and a selected other or group of the multiplicity of output terminals to be connected to the negative output bus. Respective electrodes designed for contacting cardiac tissue may then be electrically connected to each one of the multiplicity of output terminals. An electrical charge available on the positive and negative output buses may then be transferred to the body tissue as an electrical shock or stimulus through the electrodes in accordance with the programmed polarity.

摘要翻译： 可植入式心律转复除颤器（ICD）的可编程输出连接器或类似的可植入医疗设备允许多个输出端子中的每一个选择性地连接到ICD的正或负输出总线。 ICD的正和负输出总线又被切换到ICD的输出电容器或等效输出电路。 存储在输出电容器上的电荷或由输出电路产生的电荷根据编程的极性被呈现给多个输出端子。 编程的极性使所选择的一组或多组输出端连接到正输出总线，并且选择的另一组或多组输出端连接到负输出总线。 设计用于接触心脏组织的各个电极然后可以电连接到多个输出端子中的每一个。 正负输出总线上可用的电荷然后可以根据编程的极性通过电极作为电击或刺激传递到身体组织。

公开(公告)号：US5324328A

公开(公告)日：1994-06-28

申请号：US926075

申请日：1992-08-05

申请人： Hong Li ,  Phong D. Doan ,  John R. Helland

发明人： Hong Li ,  Phong D. Doan ,  John R. Helland

IPC分类号： A61N1/05 ,  A61N1/39 ,  H01B7/04

CPC分类号： A61N1/0587 ,  A61N1/05

摘要： An electrical conductor assembly utilized, for example, in a defibrillator patch lead to interconnect a pulse generator and monitoring unit, and a wire mesh electrode pad. The electrical conductor includes a Teflon insulated drawn brazed stranded (DBS) wire cable which is wrapped in a drawn filled tube (DFT) wire multifilar coil encased in a biocompatible insulative tubing.

摘要翻译： 例如，在除颤器贴片中使用的电导体组件导致将脉冲发生器和监视单元互连，以及金属丝网电极垫。 电导体包括聚四氟乙烯绝缘拉伸铜焊绞线（DBS）线缆，其被缠绕在包裹在生物相容绝缘管中的拉伸填充管（DFT）线多线圈线圈中。

公开(公告)号：US08108054B2

公开(公告)日：2012-01-31

申请号：US12365522

申请日：2009-02-04

申请人： John R. Helland

发明人： John R. Helland

IPC分类号： A61N1/00

CPC分类号： A61N1/0573 ,  A61B90/39 ,  A61B2090/0807

摘要： An implantable medical lead for active fixation to cardiac tissue is disclosed herein. The lead may include a lead body distal end, a tissue fixation helical anchor and a structure. The tissue fixation helical anchor may be coupled to the lead body distal end and include a distal tip. The structure may be coupled to the lead body distal end and include a structure distal end including a first radiopaque marker. The structure may be biased to project the structure distal end near the distal tip. When the tissue fixation helical anchor is progressively embedded in the cardiac tissue, the cardiac tissue progressively displaces the structure distal end proximally.

摘要翻译： 本文公开了用于主动固定于心脏组织的可植入医疗引线。 引线可以包括引线体远端，组织固定螺旋锚和结构。 组织固定螺旋锚可以联接到引线体远端并包括远端。 该结构可以耦合到引线体远端，并且包括具有第一不透射线标记的结构远端。 该结构可能被偏置以将结构远端突出到远侧末端附近。 当组织固定螺旋锚被逐渐嵌入心脏组织中时，心脏组织逐渐将结构远端置换为近端。