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    Characterization and Sorting for Particle Analyzers
    2.
    发明申请
    Characterization and Sorting for Particle Analyzers 有权

    公开(公告)号：US20250155352A1

    公开(公告)日：2025-05-15

    申请号：US19020951

    申请日：2025-01-14

    Applicant: Becton, Dickinson and Company

    Inventor： Jonathan Lin ,  Joseph T. Trotter ,  Keegan O. Owsley

    IPC: G01N15/1429 ,  G01N15/01 ,  G01N15/14 ,  G01N15/1404 ,  G01N15/1434 ,  G06F16/20 ,  G06F16/28 ,  G06N3/08 ,  G06N7/06 ,  G06N20/00

    Abstract: Non-parametric transforms such as t-distributed stochastic neighbor embedding (tSNE) are used to analyze multi-parametric data such as data derived from flow cytometry or other particle analysis systems and methods. These transforms may be included for dimensionality reduction and identification of subpopulations (e.g., gating). By nature, non-parametric transforms cannot transform new observations without training a new transformation based on the entire dataset including the new observations. The features described parameterize non-parametric transforms using a neural network thereby allowing a small training dataset to be transformed using non-parametric techniques. The training dataset may then be used to generate an accurate parametric model for assessing additional events in a manner consistent with the initial events.

    MODIFIED FLOW PROXY ASSAY PRIOR TO SINGLE-CELL CITE-SEQ
    8.
    发明申请
    MODIFIED FLOW PROXY ASSAY PRIOR TO SINGLE-CELL CITE-SEQ 有权

    公开(公告)号：US20250136972A1

    公开(公告)日：2025-05-01

    申请号：US18836303

    申请日：2023-03-08

    Applicant: Becton, Dickinson and Company

    Inventor： Xiaoshan Shi ,  Wei Fan ,  Majid Mehrpouyan ,  Stephanie J. Widmann-Nguyen ,  Aaron Jacob Tyznik ,  Yu Chen

    IPC: C12N15/10 ,  G01N33/68

    Abstract: Disclosed herein include systems, methods, compositions, and kits for detecting cellular component-binding reagents comprising a cellular component-binding reagent specific oligonucleotide having a unique identifier sequence for the cellular component-binding reagent. Provided herein include first detectable conjugates comprising a detectable moiety, or precursor thereof, and a unique identifier specific oligonucleotide having a sequence configured to bind a unique identifier sequence. Also provided herein are second detectable conjugates comprising a detectable moiety, or precursor thereof, and a shared oligonucleotide having a sequence configured to bind a shared sequence of the cellular component-binding reagent specific oligonucleotides.

    NON-SEQUENCING PCR-BASED METHOD FOR DETECTION OF ANTIBODY-CONJUGATED OLIGONUCLEOTIDES
    9.
    发明申请
    NON-SEQUENCING PCR-BASED METHOD FOR DETECTION OF ANTIBODY-CONJUGATED OLIGONUCLEOTIDES 有权

    公开(公告)号：US20250129405A1

    公开(公告)日：2025-04-24

    申请号：US18688919

    申请日：2022-09-07

    Applicant: Becton, Dickinson and Company

    Inventor： Tracy Campbell ,  Dennis Prosen ,  Xiaoshan Shi

    IPC: C12Q1/6804 ,  C12Q1/6841 ,  C12Q1/686

    Abstract: Disclosed herein include systems, methods, compositions, and kits for detecting antibody-conjugated oligonucleotides that do not comprise sequencing. The method can comprise generating amplicons of the unique identifier sequence of one or more of the cellular component-binding reagents. The method can comprise determining the amount of one or more amplicons as an indication of the amount of the one or more of the first cellular component-binding reagents. The method can comprise determining the amount of one or more amplicons as an indication of the amount of the cellular component targets bound by said one or more of the cellular component-binding reagents.

    Rigid Separation Barrier for a Specimen Collection Container
    10.
    发明申请
    Rigid Separation Barrier for a Specimen Collection Container 有权

    公开(公告)号：US20250128253A1

    公开(公告)日：2025-04-24

    申请号：US18691584

    申请日：2022-09-14

    Applicant: Becton, Dickinson and Company

    Inventor： Arun U. Nair ,  Shruti Wigh

    IPC: B01L3/00

    Abstract: A specimen collection container assembly including a collection tube, an interior reservoir formed within the collection tube, a gel separation substance provided within the interior reservoir, and a rigid barrier member provided within the interior reservoir. Upon collection of a specimen within the interior reservoir and centrifugation of the collection tube, the specimen is divided into two primary component parts, and the gel separation substance and the rigid barrier member migrate or are otherwise moved to a transition location between the two primary component parts so as to form a physical barrier between a first component part of the specimen and a second component part of the specimen.

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