Invention Grant
- Patent Title: Antiviral agents against HBV infection
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Application No.: US14759385Application Date: 2013-12-27
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Publication No.: US09938236B2Publication Date: 2018-04-10
- Inventor: Xiaodong Xu , Ju-Tao Guo , Tong Xiao , Yanming Du , Timothy Block , Simon David Peter Baugh , Hong Ye
- Applicant: DREXEL UNIVERSITY , BARUCH S. BLUMBERG INSTITUTE , ARBUTUS BIOPHARMA, INC.
- Applicant Address: US PA Philadelphia US PA Doylestown US PA Warminster
- Assignee: Drexel University,Baruch S. Blumberg Institute,Arbutus Biopharma, Inc.
- Current Assignee: Drexel University,Baruch S. Blumberg Institute,Arbutus Biopharma, Inc.
- Current Assignee Address: US PA Philadelphia US PA Doylestown US PA Warminster
- Agency: Saul Ewing Arnstein & Lehr LLP
- Agent Kathryn Doyle; Domingos J. Silva
- International Application: PCT/US2013/077940 WO 20131227
- International Announcement: WO2014/106019 WO 20140703
- Main IPC: C07C311/16
- IPC: C07C311/16 ; C07D213/75 ; C07D213/76 ; C07D309/04 ; C07D215/38 ; C07D215/42 ; C07D217/24 ; C07D319/18 ; C07D231/40 ; C07D231/42 ; C07D239/26 ; C07D261/14 ; C07D263/48 ; C07D263/50 ; C07D203/26 ; C07D263/58 ; C07D205/04 ; C07D277/46 ; C07D277/52 ; C07D211/96 ; C07D295/26 ; C07D295/30 ; C07D213/40 ; C07D305/08 ; C07C309/89 ; C07C311/17 ; C07C311/18 ; C07C311/19 ; C07C311/20 ; C07C311/48 ; C07C233/66 ; C07C317/14 ; C07D295/32 ; C07D319/16
Abstract:
The present invention provides novel compounds of formula (I) and methods of use thereof. In certain embodiments, the compounds of the invention are useful as nucleocapsid assembly inhibitors. In other embodiments, the compounds of the invention are useful as pregenomic RNA encapsidation inhibitors of Hepatitis B virus (HBV). In yet other embodiments, the compounds of the invention are useful for the treatment of viral infection, including HBV and related viral infections.
Public/Granted literature
- US20160024004A1 NOVEL ANTIVIRAL AGENTS AGAINST HBV INFECTION Public/Granted day:2016-01-28
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