发明授权
- 专利标题： Method and agents for inhibiting protein aging
- 专利标题（中）： 抑制蛋白质老化的方法和试剂
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申请号： US798032申请日： 1985-11-14
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公开(公告)号： US4758583A公开(公告)日： 1988-07-19
- 发明人: Anthony Cerami , Peter C. Ulrich , Michael Brownlee
- 申请人： Anthony Cerami , Peter C. Ulrich , Michael Brownlee
- 申请人地址： NY New York
- 专利权人： The Rockefeller University
- 当前专利权人： The Rockefeller University
- 当前专利权人地址： NY New York
- 主分类号： C07H3/02
- IPC分类号： C07H3/02 ; A23J3/00 ; A23L3/3526 ; A61K8/40 ; A61K8/42 ; A61K8/43 ; A61K8/44 ; A61K31/155 ; A61K31/195 ; A61K31/415 ; A61K31/4178 ; A61K38/19 ; A61K38/20 ; A61K38/21 ; A61K38/38 ; A61K39/00 ; A61P3/06 ; A61P3/08 ; A61P3/10 ; A61P9/10 ; A61P9/12 ; A61P13/02 ; A61P15/00 ; A61P17/00 ; A61P27/02 ; A61P43/00 ; A61Q11/00 ; A61Q19/00 ; A61Q19/08 ; C07D405/00 ; C07D405/14 ; C07K14/00 ; C07K14/435 ; C07K14/76 ; C07K16/00 ; C07K16/28 ; C09K11/06 ; C12Q1/00 ; G01N21/76 ; G01N21/78 ; G01N33/53 ; G01N33/533 ; G01N33/573 ; G01N33/58 ; G01N33/66 ; G01N33/68 ; C07C128/00 ; C07C129/00 ; C12N1/06
摘要：
The present invention relates to compositions and methods for inhibiting protein aging. Accordingly, a composition is disclosed which comprises an agent or compound capable of inhibiting the formation of advanced glycosylation end products of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. Suitable agents may contain an active nitrogen-containing group, such as a hydrazine group, and may further be at least partially derived from amino acids. Particular agents comprise aminoguanidine, .alpha.-hydrazinohistidine and lysine. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
公开/授权文献
- US5989539A Compounds and compositions for delivering active agents 公开/授权日：1999-11-23
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