The invention relates to a production process for preventing a high-cracking-sensitive-index steel plate generating edge cracking. The production process is characterized by concretely comprising thefollowing steps that (1) high-temperature low-speed and great-pressure operation is used for plate blank rolling; (2) after the rolling, slow cooling is performed as soon as possible; (2) the time intervals of the heat treatment are short; (4) after the cutting, chamfering trimming and grinding are performed. Compared with the prior art, the production process has the beneficial effects that the proportion of the steel plate for generating the edge cracks is reduced to be 0.5 percent or below; the problem of edge cracking generated by an F20 steel plate in the production, cutting, hanging conveying and storage processes is thoroughly solved; the generation of a great number of waste products is avoided; the maximum benefits are realized.