The invention provides a high-strength high-toughness pipe for a crane boom. The high-strength high-toughness pipe consists of the following components in percentage by mass: 0.14-0.18% of C, 0.30-0.50% of Si, 1.30-1.50% of Mn, less than or equal to 0.015% of P, less than or equal to 0.008% of S, 0.35-0.50% of Cr, 0.10-0.20% of Ni, 0.25-0.38% of Mo, 0.07-0.12% of V, less than or equal to 0.05% of Ti, 0.30-0.45% of W, 0.02-0.05% of Al, less than or equal to 0.02% of Cu, less than or equal to 0.05% of Nb, less than or equal to 0.007% of N, and the balance iron and impurities. Ferrotitanium is added 5-8 minutes before ending external refining. A pipe blank heating temperature ranges from 1260 DEG C to 1280 DEG C; a steel pipe quenching temperature ranges from 920 DEG C to 930 DEG C, a tempering temperature ranges from 690 DEG C to 700 DEG C, and thermal insulation time ranges from 40 minutes to 60 minutes. The process is simple and easy to realize; the boom is welded and judged according to the technical requirements of standard Pressure-bearing Equipment Welding Procedure Qualification NB/T47014-2011; bending tests such as a room-temperature tensile test, a lateral bending test, a surface bending test and a back bending test as well as a low-temperature impact test at (-)40 DEG C of the boom are qualified; and moreover, production performances are uniform and stability is good.