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发明授权
CN101678020B 作为Janus激酶的酪氨酸激酶活性抑制剂的喹喔啉衍生物 失效 - 权利终止

作为Janus激酶的酪氨酸激酶活性抑制剂的喹喔啉衍生物
摘要：
本发明涉及式(I)的喹喔啉化合物及其在治疗疾病、特别是由包括JAK-2和JAK-3激酶的Janus激酶的酪氨酸激酶活性介导的疾病的用途：，其中R1为碳环基或杂环基，其中任何一个任选被1、2、3、4或5个R7取代；R2为碳环基或杂环基，其中任何一个任选被1、2、3、4或5个R8取代；R3、R4、R5和R6各自独立为氢或R9；且R7、R8和R9各自独立选自有机和无机取代基。
摘要（英）：

The present invention relates to quinoxaline compound of the formula (I): wherein R1 is carbocycly! or heterocyclyl, either of which is optionally substituted with 1, 2, 3, 4 or 5 R7; R2 is carbocyclyl or heterocyclyl, either of which is optionally substituted with 1, 2, 3, 4 or 5 R8; R3, R4, R5 and R6 are each independently hydrogen or R9; and R7, R8 and R9 are each independently selected from organic and inorganic substituents, their use in therapy of diseases, in particular diseases mediated by the tyrosine kinase activity of Janus kinases, including JAK-2 and JAK-3 kinases.

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