公开(公告)号：US12174177B2

公开(公告)日：2024-12-24

申请号：US18405536

申请日：2024-01-05

Applicant: Redcoat Solutions, Inc.

Inventor： William John Hall ,  Benedict Louis Zin ,  Andy Sturman ,  Min Wang

IPC: G01N33/53 ,  C07K16/00 ,  C07K16/18 ,  G01N21/78 ,  G01N21/84 ,  G01N33/543 ,  G01N33/553 ,  G01N33/558 ,  G01N33/68 ,  G01N21/77

Abstract: System and method embodiments for analyzing a test fluid to detect prior or present infestations of bed bugs are described. In an embodiment, the method may include receiving the test fluid on a test strip within the detection device. The test strip may include a reaction portion and a reagent portion containing an antibody or antigen-binding fragment that is conjugated to a colored particle. The test fluid may include bed bug antigen that reacts with the conjugated antibody. The detection device may include a first and a second optical sensor for monitoring a reaction and a background color intensity, respectively. Upon a predetermined time delay elapsing, the detection device determines whether bed bug antigen is present in the test fluid using the monitored color intensities and minimum and maximum color intensity thresholds associated with bed bugs. Then, the detection device outputs a result using a visual display.

公开(公告)号：US20240410881A1

公开(公告)日：2024-12-12

申请号：US18812046

申请日：2024-08-22

Applicant: Laboratory Corporation of America Holdings

Inventor： Mary Katherine Morr Kelemen ,  Brett Holmquist

IPC: G01N33/543 ,  G01N21/552 ,  G01N33/548 ,  G01N33/553 ,  G01N33/68

Abstract: The present disclosure relates to a method for detection of an antibody or antibody fragment in a biological sample from a subject. In some embodiments, the methods comprise immobilizing a first binding agent on a surface plasmon resonance (SPR) biosensor; adding a ligand that binds to the first binding agent under conditions such that a complex of the ligand and the first binding agent is formed; adding an aliquot of the biological sample under conditions such that the antibody and/or antibody fragment binds to the ligand that is complexed to the first binding agent; and detecting the presence of the antibody and/or antibody fragment as a change in signal obtained from SPR. In some embodiments, the antibody is an antibody therapeutic such as certolizumab pegol. Also disclosed are systems and kits for detecting an antibody in a biological sample from a subject using SPR.

公开(公告)号：US20240319186A1

公开(公告)日：2024-09-26

申请号：US18271640

申请日：2022-01-11

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Hong Gi KIM ,  Jung KIM ,  Bum Tae KIM ,  Jonghwan LEE ,  Nam Hoon KIM ,  Sung Kyun LEE

IPC: G01N33/569 ,  G01N21/64 ,  G01N33/531 ,  G01N33/553

CPC classification number: G01N33/56983 ,  G01N21/6428 ,  G01N33/531 ,  G01N33/553 ,  G01N2021/6439 ,  G01N2333/165 ,  G01N2469/20

Abstract: The present invention relates to a nanowire-based immunofluorescence kit for detecting a SARS coronavirus 2 antibody, and a use thereof, and more specifically, to a zinc oxide nanowire-based immunofluorescence kit for detecting a SARS coronavirus 2 antibody, and a use thereof, the kit comprising a step of growing nanowires on a substrate, introducing a functional group on the grown nanowires, and fixing a SARS coronavirus 2 antigen. The nanowire array of the present invention has enhanced detection sensitivity to enable more accurate diagnosis of whether or not a SARS coronavirus 2 antibody is produced.

公开(公告)号：US12099059B2

公开(公告)日：2024-09-24

申请号：US17037830

申请日：2020-09-30

Applicant: BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS

Inventor： Alexandru S. Biris ,  Zeid Nima ,  Yang Xu

IPC: G01N33/543 ,  G01N33/553

CPC classification number: G01N33/54346 ,  G01N33/54353 ,  G01N33/553

Abstract: A method of making at least one nanocomposite for surface enhanced Raman spectroscopy (SERS) detection of a target of interest includes forming at least one gold nanorod; coating a silver layer on an outer surface of the gold nanorod; assembling a Raman reporter molecule layer on the coated silver layer, wherein the Raman reporter molecule layer comprises Raman reporter molecules that are detectable by the SERS; coating a thiolated polyethylene glycol (PEG) layer on the assembled Raman reporter molecule layer; and conjugating the coated thiolated PEG layer with molecules of an antibody to make the at least one nanocomposite.

公开(公告)号：US20240192204A1

公开(公告)日：2024-06-13

申请号：US17998556

申请日：2021-05-17

Applicant: Universal Sequencing Technology Corporation

Inventor： Peiming Zhang ,  Ming Lei ,  Sanjay B. Hari

IPC: G01N33/543 ,  G01N33/553 ,  G01N33/569

CPC classification number: G01N33/54388 ,  G01N33/54346 ,  G01N33/553 ,  G01N33/56983 ,  G01N2333/165

Abstract: This invention provides a device and assays for the detection of pathogens.

公开(公告)号：US11977072B2

公开(公告)日：2024-05-07

申请号：US16479663

申请日：2018-01-30

Applicant: ZOETIS SERVICES LLC

Inventor： Rajesh K. Mehra ,  Kenneth P. Aron ,  Vincent Chiang ,  Sarah Ann Unser

IPC: G01N33/543 ,  G01N21/53 ,  G01N21/552 ,  G01N33/553

CPC classification number: G01N33/54346 ,  G01N21/554 ,  G01N33/553 ,  G01N2469/10 ,  G01N2469/20

Abstract: The present invention relates to nanostructure-binding partner conjugates, as well as reaction mixtures, analyte detection devices, and methods of making and using the conjugates. In particular, the invention provides a method of detecting a target analyte in a sample comprising mixing the sample with a first detection conjugate and a second detection conjugate in solution, wherein the first and second detection conjugates comprise metallic nanostructures coupled to binding partners that are capable of specifically binding to the target analyte if present in the sample to form a complex between the first detection conjugate, the analyte, and the second detection conjugate, wherein a change in an optical signal upon complex formation indicates the presence of the target analyte in the sample.

公开(公告)号：US20230375541A1

公开(公告)日：2023-11-23

申请号：US18029698

申请日：2021-10-04

Applicant: University of Houston System ,  Board of Regents, The University of Texas System

Inventor： Wei-Chuan Shih ,  Nareg Ohannesian ,  Steven H. Lin

IPC: G01N33/543 ,  B82Y5/00 ,  G01N33/553 ,  G01N33/569 ,  G01N33/574

CPC classification number: G01N33/54346 ,  B82Y5/00 ,  G01N33/553 ,  G01N33/569 ,  G01N33/574

Abstract: Ultra near-field index modulated plasmonic nano-aperture label-free imaging methods and techniques are useful for imaging and detection of biological microparticles and nanoparticles such as circulating tumor exosomes (CTEs), bacteria and vimses. The methods and techniques utilize a high-density array of gold, silver, or gold/silver alloy nanodisks, in some cases on an undercut or invisible substrate. Given the relatively large nanodisk dimensions, the nanodisk array may feature a significantly blue-shifted LSPR extinction peak due to both far-field plasmonic coupling and substrate undercut. The ultra near-field imaging methods have the ability to image nanoparticles as small as 25 nm.

公开(公告)号：US11779896B2

公开(公告)日：2023-10-10

申请号：US16987816

申请日：2020-08-07

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Young Keun Kim ,  Yu Jin Kim ,  Bum Chul Park ,  Myeong Soo Kim

IPC: B01J13/02 ,  B03C1/30 ,  G01N33/543 ,  G01N33/553 ,  B82Y40/00 ,  B82Y15/00 ,  B82Y35/00

CPC classification number: B01J13/02 ,  B03C1/30 ,  G01N33/54326 ,  G01N33/54346 ,  G01N33/54353 ,  G01N33/553 ,  B82Y15/00 ,  B82Y35/00 ,  B82Y40/00

Abstract: The present invention relates to a magnetic-optical composite nanostructure, which has a heterogeneous nature due to consisting of a first core-shell nanoparticle and second core-shell nanoparticles and thus realizes magnetic and optical functions at the same time.

公开(公告)号：US20230258633A1

公开(公告)日：2023-08-17

申请号：US18014220

申请日：2021-07-07

Applicant: The Regents of the University of California

Inventor： Timothy RODWELL ,  Antonino CATANZARO ,  Marva SEIFERT ,  Joseph WANG ,  Eva Vargas ORGAZ ,  Victor Ruiz Valdepenas MONTIEL

IPC: G01N33/569 ,  G01N27/327 ,  G01N33/553 ,  C07K16/12 ,  C07K16/10

CPC classification number: G01N33/569 ,  G01N27/327 ,  G01N33/553 ,  C07K16/1289 ,  C07K16/10 ,  G01N2333/35 ,  G01N2333/165

Abstract: In one aspect, the disclosure relates to test strips for detecting and/or monitoring the treatment of a disease in a subject. The test strips are inexpensive and disposable and can be used directly with clinical biological samples from patients including, but not limited to, blood, plasma, saliva, and urine. Also disclosed are methods of using the test strips to quantify antigens produced by a virus or microorganism causing an infectious disease. The methods can be conducted at a point of care for a patient and do not require expensive equipment or extensive operator training. The methods are also rapid to complete and can be used to monitor progress in the treatment of a disease This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US20230243816A1

公开(公告)日：2023-08-03

申请号：US18159857

申请日：2023-01-26

Applicant: MYTECH CO. LTD.

Inventor： Yuki HASEGAWA ,  Katsuyuki HASEGAWA

IPC: G01N33/543 ,  G01N33/553 ,  G01N33/569

CPC classification number: G01N33/54306 ,  G01N33/553 ,  G01N33/56983 ,  G01N2333/165

Abstract: The present invention relates to a system capable of performing simple and rapid inspection of an antigen equivalent to the immune chromatographic method with accuracy good as a PCR method. An embodiment relates to a novel fluorescence counting system for quantifying viruses or antibodies in an analyte which comprises an unit of providing an antigen or antibody phase solidified substrate by an aggregation method with quantum crystals, an unit for making a labeling liquor and labeling a virus or an antibody to be measured in the analyte by an antigen-antibody method, an unit of exciting the fluorescently labeled virus or antibody by a surface plasmon excitation method, and an unit of counting fluorescent points in an excited fluorescent screen to quantify the virus or antibody in the analyte.