公开(公告)号：US20240361214A1

公开(公告)日：2024-10-31

申请号：US18754887

申请日：2024-06-26

申请人： BD KIESTRA B.V.

发明人： Timothy Roy Hansen ,  Martijn Kleefstra ,  Michael Bois ,  Timothy M. Wiles ,  Charles Chak Cheung Yu

IPC分类号： G01N1/38 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/40

CPC分类号： G01N1/38 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/40 ,  G01N2001/386

摘要： An automated method for preparing a sample suspension. The sample suspension can be used for both MALDI and antimicrobial susceptibility (AST). A suspension is prepared, and a portion of that suspension is removed for a first analysis (e.g. MALDI), leaving a remaining volume. The turbidity of the remaining volume is measured. If the turbidity is below a first threshold, the suspension is not used for a second analysis (e.g. AST) and is subjected to a concentration protocol to raise the turbidity of the suspension. If the turbidity is within a predetermined range, a volume of the suspension is calculated that will deliver a predetermined amount of sample to a vessel for the second analysis. If the turbidity of the suspension is above the predetermined range, and the suspension has not been diluted a predetermined number of times, the suspension is diluted according to a dilution protocol.

公开(公告)号：US12123814B1

公开(公告)日：2024-10-22

申请号：US16900019

申请日：2020-06-12

申请人： Pierce Biotechnology, Inc.

发明人： Barbara Kaboord ,  Joanna Geddes ,  Christopher Wojewodzki ,  Kay Opperman ,  Scott Meier

IPC分类号： C07K1/14 ,  C07K14/705 ,  C07K14/72 ,  G01N1/40 ,  C07H3/04 ,  C07J9/00 ,  C07J41/00

CPC分类号： G01N1/4044 ,  C07K1/145 ,  C07K14/705 ,  C07K14/723 ,  C07H3/04 ,  C07J9/00 ,  C07J41/0033 ,  G01N2001/4061

摘要： Formulations for extraction and stabilization of G-Protein Coupled Receptors (GPCRs), kits and methods for their use for extracting GPCRs from biological specimens (e.g., cells and tissues), and methods for making such formulations in bulk scale are described. GPCRs extracted from cells and tissues using the described formulations remain in a functional, solubilized form over extended time periods.

公开(公告)号：US20240344017A1

公开(公告)日：2024-10-17

申请号：US18444673

申请日：2024-02-17

申请人： S2 Genomics, Inc.

发明人： Stevan Bogdan Jovanovich ,  Kaiwan Chear ,  Bruce Leisz ,  David Eberhart ,  John Bashkin

IPC分类号： C12M1/33 ,  C12M1/00 ,  C12M1/34 ,  C12N1/06 ,  G01N1/28 ,  G01N1/31 ,  G01N1/40

CPC分类号： C12M45/02 ,  C12M41/12 ,  C12M45/06 ,  C12M45/09 ,  C12M45/20 ,  C12N1/066 ,  G01N1/286 ,  G01N1/31 ,  G01N1/4077 ,  G01N2001/4088

摘要： A system, methods, and apparatus are described to collect and prepare single cells, nuclei, subcellular components, and biomolecules from specimens including tissues and in some embodiments use the single cells to form organoids or microtissues. The system can perform enzymatic and/or physical disruption of the tissue to dissociate it into single-cells and then use a hanging droplet method to form organoids or microtissues.

公开(公告)号：US12117378B2

公开(公告)日：2024-10-15

申请号：US18205397

申请日：2023-06-02

申请人： 10X GENOMICS, INC.

发明人： Christopher Hindson ,  Andrew D. Price ,  Michael Schnall-Levin

IPC分类号： G01N1/28 ,  C12N5/00 ,  G01N1/40

CPC分类号： G01N1/28 ,  C12N5/0006 ,  G01N1/4077 ,  C12N2537/10

摘要： Methods and systems for cell and bead processing or analysis are provided. A cell or bead can be subjected to conditions sufficient to change a first characteristic or set of characteristics (e.g., cell or bead size). The cell or bead can further be subjected to conditions sufficient to change a second characteristic or set of characteristics. In some cases, crosslinks are formed within the cell or bead.

公开(公告)号：US20240337639A1

公开(公告)日：2024-10-10

申请号：US18746379

申请日：2024-06-18

申请人： Precision Planting LLC

发明人： Richard Petroski ,  Rachel Nelson

IPC分类号： G01N31/22 ,  G01N1/40 ,  G01N21/80 ,  G01N33/24

CPC分类号： G01N31/221 ,  G01N1/4055 ,  G01N21/80 ,  G01N33/24 ,  G01N2001/4061 ,  G01N2001/4088 ,  G01N33/245

摘要： Compositions for testing soil to measure one or more of the following properties of soil: pH, buffer pH, potassium, phosphorus, calcium, and/or magnesium. Test methods for testing soil to measure one or more of the following properties of soil: pH, buffer pH, potassium, phosphorus, calcium, and/or magnesium. A multichamber cartridge containing two or more of the compositions in separate chambers.

公开(公告)号：US20240337637A1

公开(公告)日：2024-10-10

申请号：US18746362

申请日：2024-06-18

申请人： Precision Planting LLC

发明人： Richard Petroski ,  Rachel Nelson

IPC分类号： G01N31/22 ,  G01N1/40 ,  G01N21/80 ,  G01N33/24

CPC分类号： G01N31/221 ,  G01N1/4055 ,  G01N21/80 ,  G01N33/24 ,  G01N2001/4061 ,  G01N2001/4088 ,  G01N33/245

摘要： Compositions for testing soil to measure one or more of the following properties of soil: pH, buffer pH, potassium, phosphorus, calcium, and/or magnesium. Test methods for testing soil to measure one or more of the following properties of soil: pH, buffer pH, potassium, phosphorus, calcium, and/or magnesium. A multichamber cartridge containing two or more of the compositions in separate chambers.

公开(公告)号：US20240337633A1

公开(公告)日：2024-10-10

申请号：US18746327

申请日：2024-06-18

申请人： Precision Planting LLC

发明人： Richard Petroski ,  Rachel Nelson

IPC分类号： G01N31/22 ,  G01N1/40 ,  G01N21/80 ,  G01N33/24

CPC分类号： G01N31/221 ,  G01N1/4055 ,  G01N21/80 ,  G01N33/24 ,  G01N2001/4061 ,  G01N2001/4088 ,  G01N33/245

摘要： Compositions for testing soil to measure one or more of the following properties of soil: pH, buffer pH, potassium, phosphorus, calcium, and/or magnesium. Test methods for testing soil to measure one or more of the following properties of soil: pH, buffer pH, potassium, phosphorus, calcium, and/or magnesium. A multichamber cartridge containing two or more of the compositions in separate chambers.

公开(公告)号：US20240337632A1

公开(公告)日：2024-10-10

申请号：US18746314

申请日：2024-06-18

申请人： Precision Planting LLC

发明人： Richard Petroski ,  Rachel Nelson

IPC分类号： G01N31/22 ,  G01N1/40 ,  G01N21/80 ,  G01N33/24

CPC分类号： G01N31/221 ,  G01N1/4055 ,  G01N21/80 ,  G01N33/24 ,  G01N2001/4061 ,  G01N2001/4088 ,  G01N33/245

摘要： Compositions for testing soil to measure one or more of the following properties of soil: pH, buffer pH, potassium, phosphorus, calcium, and/or magnesium. Test methods for testing soil to measure one or more of the following properties of soil: pH, buffer pH, potassium, phosphorus, calcium, and/or magnesium. A multichamber cartridge containing two or more of the compositions in separate chambers.

公开(公告)号：US20240328935A1

公开(公告)日：2024-10-03

申请号：US18579418

申请日：2022-07-15

申请人： Manfred Dausch

发明人： Manfred Dausch

IPC分类号： G01N21/33 ,  C12C11/00 ,  G01N1/40 ,  G01N33/14

CPC分类号： G01N21/33 ,  C12C11/003 ,  G01N1/4077 ,  G01N33/146 ,  G01N2001/4083

摘要： Methods and systems for automated quality monitoring of the fermentation process and/or for determining the end point of fermentation during the beer brewing process in the production of beer by determining one or more aroma components or other ingredients of the beer.

公开(公告)号：US20240328906A1

公开(公告)日：2024-10-03

申请号：US18598355

申请日：2024-03-07

申请人： Georgia Tech Research Corporation

发明人： Andrei G. FEDOROV ,  Mason CHILMONCZYK ,  Peter Arthur KOTTKE

IPC分类号： G01N1/20 ,  G01N1/40

CPC分类号： G01N1/2035 ,  G01N1/40 ,  G01N2001/205

摘要： The present disclosure provides for analysis systems that are configured to extract a fluid sample from a fluid (e.g., aqueous solution) in a reactor (e.g., bioreactor) at a first rate and then flow the fluid sample to a sensor system at a second rate to analyze the fluid sample. The sensor system can detect the presence and/or concentration of molecules (e.g., biomolecules such as biomarkers (e.g., metabolites, proteins, peptides, cytokines, growth factors, DNA, RNA, lipids) and cells of different types and cell properties, e.g., mechanical stiffness, etc.)). The data obtained can be used by a feedback control system to modify, as needed, the conditions in the reactor to enhance the productively of the reactor.