公开(公告)号：US11969443B2

公开(公告)日：2024-04-30

申请号：US17436432

申请日：2020-03-06

申请人： LENTIGEN TECHNOLOGY, INC.

发明人： Dina Schneider ,  Boro Dropulic ,  Brian Robert Webster

IPC分类号： A61K35/17 ,  A61K48/00 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28 ,  C12N15/11 ,  C12N15/31

CPC分类号： A61K35/17 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70578 ,  C07K16/2803 ,  C07K2317/622 ,  C07K2319/03

摘要： Self-driving surface antigen-regulated promoter-therapeutic payload constructs containing antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the surface antigen-regulated promoter-therapeutic payload constructs are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making self-driving surface antigen-regulated promoter-therapeutic payload constructs in T-cells are also disclosed.

公开(公告)号：US11911415B2

公开(公告)日：2024-02-27

申请号：US15579633

申请日：2016-06-09

申请人： EDITAS MEDICINE, INC.

发明人： Jennifer Leah Gori ,  Tongyao Wang ,  Hariharan Jayaram ,  Penrose ODonnell

IPC分类号： C12N5/078 ,  A61K35/14 ,  C12N15/113 ,  C12N15/31 ,  G16B50/00 ,  A61K35/28 ,  G16B40/00 ,  C12N15/11 ,  C07K14/74 ,  C12N5/0789 ,  C12N9/22 ,  C12N15/86

CPC分类号： A61K35/28 ,  C07K14/70539 ,  C12N5/0647 ,  C12N9/22 ,  C12N15/11 ,  C12N15/111 ,  C12N15/86 ,  G16B40/00 ,  G16B50/00 ,  C12N2310/20

摘要： Disclosed herein are compositions and methods for increasing the immunocompatibility of donor cells (e.g., HSCs or T-cells) for transplantation to a recipient subject, as well as database schemes for use in the methods. The methods and compositions described herein result in the allele-specific modification of one or more immunogenicity genes (e.g., an HLA gene) of a cell, resulting in cells that are suitable for transplantation into a recipient subject.

公开(公告)号：US11878052B2

公开(公告)日：2024-01-23

申请号：US16773379

申请日：2020-01-27

申请人： LentigenTechnology, Inc. ,  The U.S.A., as represented by the Secretary, Department of Health and Human Services

发明人： Rimas J. Orentas ,  Dina Schneider ,  Boro Dropulic ,  Dimiter S. Dimitrov ,  Zhongyu Zhu

IPC分类号： C12N15/113 ,  C12N15/31 ,  C07K14/47 ,  A61K35/17 ,  A61K39/00 ,  C07K16/28 ,  C07K14/705 ,  C07K14/725 ,  A61P35/00

CPC分类号： A61K39/001113 ,  A61P35/00 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70578 ,  C07K16/2803 ,  A61K2039/505 ,  A61K2039/5156 ,  A61K2039/5158 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/33

摘要： Chimeric antigen receptors (CARs) containing CD22 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the CARs are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making CAR T cells are also disclosed.

公开(公告)号：US11542489B2

公开(公告)日：2023-01-03

申请号：US17386106

申请日：2021-07-27

申请人： Roche Diagnostics Operations, Inc.

发明人： Thomas Greiner-Stoeffele ,  Stefan Schoenert

IPC分类号： C12N9/54 ,  C12N15/31 ,  C12N15/57 ,  C12N1/19 ,  C12N9/52 ,  C07K14/195 ,  C12N5/071

摘要： The present disclosure provides the sequence of a Paenibacillus polymyxa preproenzyme which is the precursor of a neutral protease, expression thereof in a transformed host organism, and methods for production of the neutral protease, by recombinant means. Further, use of the recombinantly produced neutral protease is disclosed in the field of cell biology, particularly for the purpose of tissue dissociation. The disclosure also includes blends with other proteases. Further disclosed are nucleotide sequences encoding the neutral protease.

公开(公告)号：US10960063B2

公开(公告)日：2021-03-30

申请号：US16285008

申请日：2019-02-25

申请人： Pastoral Greenhouse Gas Research LTD.

发明人： Eric Heinz Altermann ,  Graeme Trevor Attwood ,  Gregory Cook ,  Debjit Dey ,  Scott A. Ferguson ,  Petrus Hendricus Janssen ,  William John Kelly ,  Zhanhao Kong ,  Suzanne Lambie ,  Sinead Christine Leahy ,  Dong Li ,  Duncan McMillan ,  Sharla McTavish ,  Diana Pacheco ,  Robert Starr Ronimus ,  Carrie Sang ,  Carl Yeoman

IPC分类号： C12N15/31 ,  C07K14/195 ,  C07K16/12 ,  A61K39/00 ,  C12N15/74

摘要： The present invention includes the complete genome sequence for the methanogen, Methanobrevibacter ruminan-tium, including polynucleotides which encode M. ruminantium polypeptides or peptides, as well as polynucleotides from non-coding regions. Also included are the encoded M. ruminantium polypeptides and peptides, and antibodies directed to these peptides or polypeptides, in addition to expression vectors and host cells for producing these peptides, polypeptides, polynucleotides, and antibodies. The invention further includes methods and compositions for detecting, targeting, and inhibiting microbial cells, especially methanogen cells such as M. ruminantium cells, using one or more of the disclosed peptides, polypeptides, polynu-cleotides, antibodies, expression vectors, and host cells.

公开(公告)号：US10538793B2

公开(公告)日：2020-01-21

申请号：US15539555

申请日：2015-12-24

申请人： KYOTO UNIVERSITY ,  NISSHIN PHARMA INC.

发明人： Jun Ogawa ,  Akinori Ando ,  Eiji Sakuradani ,  Sakayu Shimizu ,  Shigeru Hiramoto ,  Masataka Harata ,  Yuki Takemoto

IPC分类号： C12N9/02 ,  C12N15/31 ,  C12N15/53 ,  C12P7/64

摘要： Provided is ω3 desaturase having high enzymatic activity even at normal temperature. A polypeptide which consists of an amino acid sequence having an identity of 80% or more with the amino acid sequence represented by SEQ ID NO: 2 and has ω3 desaturation activity on C20 fatty acid, and a gene thereof.

公开(公告)号：US10208324B2

公开(公告)日：2019-02-19

申请号：US15103045

申请日：2014-12-08

申请人： BASF SE

发明人： Hartwig Schröder ,  Holger Hartmann ,  Qingzhao Wang ,  Shakir Ratani ,  Zheyuan Guo ,  Markus Pompejus

IPC分类号： C12N15/31 ,  C12P13/06 ,  C07K14/245 ,  C12N1/20 ,  C12N9/06 ,  C12P7/04 ,  C12P7/46 ,  C12P7/56 ,  C12P13/08 ,  C12P13/20

摘要： The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.

公开(公告)号：US10196656B2

公开(公告)日：2019-02-05

申请号：US15065717

申请日：2016-03-09

申请人： Alliance for Sustainable Energy, LLC

发明人： Christopher W. Johnson ,  Gregg T. Beckham

IPC分类号： C12N9/02 ,  C12N9/04 ,  C12N15/31 ,  C12N15/53 ,  C12N1/21 ,  C12P7/22

摘要： Disclosed herein are enzymes and organisms useful for the dealkylation of products derived from lignin depolymerization, including the conversion of guaiacol or guaethol to catechol or the conversion of anisole to phenol. Methods of converting guaiacol or guaethol to catechol or anisole to phenol using enzymes or organisms expressing the same are also disclosed.

公开(公告)号：US09896718B2

公开(公告)日：2018-02-20

申请号：US13748402

申请日：2013-01-23

申请人： Dow AgroSciences LLC

发明人： Yunxing C. Cui ,  Raina King ,  Tina M. Kaiser ,  Andrew E. Robinson ,  Dayakar Pareddy ,  Sandra G. Toledo ,  Leon B. Braxton ,  David M. Anderson ,  Terry R. Wright

IPC分类号： C12N15/82 ,  C12N5/04 ,  C12N15/11 ,  C12N15/31 ,  A01H5/10 ,  C12Q1/68 ,  A01H1/04

CPC分类号： C12Q1/6813 ,  A01H1/04 ,  C12N15/8274 ,  C12N15/8277 ,  C12Q1/6895 ,  C12Q2600/16

摘要： Cotton event pDAB4468.18.07.1 comprises genes encoding AAD-12 and PAT, affording herbicide tolerance to cotton crops containing the event, and enabling methods for crop protection.

公开(公告)号：US09895432B2

公开(公告)日：2018-02-20

申请号：US14312162

申请日：2014-06-23

申请人： Hasumi International Research Foundation

发明人： Kenichiro Hasumi ,  Mikio Kuraya

IPC分类号： A61K39/05 ,  C07K14/195 ,  C12N15/31 ,  C12Q1/68 ,  C07K16/12 ,  A61P17/10 ,  C07K7/08 ,  C12N15/63 ,  A61K39/02 ,  A61K31/7088 ,  A61K38/16 ,  C07K14/36 ,  A61K45/06 ,  A61K39/00

CPC分类号： A61K39/0208 ,  A61K31/7088 ,  A61K38/164 ,  A61K39/05 ,  A61K45/06 ,  A61K2039/53 ,  A61K2039/55516 ,  A61K2039/55588 ,  A61K2039/58 ,  A61K2039/645 ,  A61K2039/70 ,  C07K14/195 ,  C07K14/36 ,  C07K2319/30 ,  A61K2300/00

摘要： The invention relates to compositions, methods and therapies for the treatment of inflammation caused by infection with Propionibacterium acnes. The compositions include a combination of peptide and anti-TNF. The peptide consists of a specific amino acid sequence or a peptide consisting of an amino acid sequence derived the specific amino acid sequence by deletion, substitution, insertion or addition of one or more amino acids. The administration of the peptide and anti-TNF in therapeutically effective amounts to a patient is effective to suppress, by immune response, inflammation caused by infection with Propionibacterium acnes.