公开(公告)号：US10711025B2

公开(公告)日：2020-07-14

申请号：US16373118

申请日：2019-04-02

Applicant: INTERQUIM, S.A.

Inventor： Francisco Javier López Cremades

IPC: C07H17/07 ,  C07H1/00

Abstract: Provided is a process for the preparation of diosmin from hesperidin. The process involves the oxidation of acylated hesperidin with iodine or bromine in a C2-C4 carboxylic acid medium and subsequent treatment with an inorganic base to partially neutralize the acidic media. The process allows obtaining diosmin with low iodine or bromine content, avoiding the use of organic solvents.

公开(公告)号：US20190248825A1

公开(公告)日：2019-08-15

申请号：US16097120

申请日：2018-01-31

Applicant: Masamitsu Moriwaki ,  Kentaro Kumoi ,  Makoto Ozeki

Inventor： Masamitsu Moriwaki ,  Kentaro Kumoi ,  Makoto Ozeki

IPC: C07H17/07 ,  A23L3/3499 ,  A61K47/40 ,  A61K8/60 ,  A61K8/73 ,  A61K31/7048

Abstract: A method for producing a flavonoid inclusion compound, including a cleaving step including treating a sparingly soluble flavonoid having a rhamnoside structure with an enzyme having a rhamnosidase activity in the presence of a cyclodextrin to cleave a rhamnose. According to the production method of the present invention, a flavonoid inclusion compound and a composition of flavonoid glycosides having excellent solubility in water can be efficiently produced, so that the compound and composition can be suitably utilized in the fields of medicaments, foodstuff, health foods, foods for specified health use, cosmetics, and the like.

公开(公告)号：US10287310B2

公开(公告)日：2019-05-14

申请号：US15544174

申请日：2016-02-02

Applicant: INTERQUIM, S.A.

Inventor： Francisco Javier López Cremades

IPC: C07H1/00 ,  C07H17/07

Abstract: The present invention relates to a process for the preparation of diosmin from hesperidin. The process involves the oxidation of acylated hesperidin with iodine or bromine in a C2-C4 carboxylic acid medium and subsequent treatment with an inorganic base to partially neutralize the acidic media. The process allows obtaining diosmin with low iodine or bromine content, avoiding the use of organic solvents.

公开(公告)号：US20180201639A1

公开(公告)日：2018-07-19

申请号：US15745784

申请日：2015-06-29

Applicant: FOSHAN GOLDEN HEALTH TECHNOLOGY CO., LTD.

Inventor： Lianquan GU ,  Changyou WU ,  Jinlin ZHOU ,  Yujing LU ,  Tianmiao OU ,  Baohua HUANG ,  Liwei LIN

IPC: C07H17/07 ,  C07H1/00 ,  C12P19/60

CPC classification number: C07H17/07 ,  A61K8/602 ,  A61K9/0014 ,  A61P31/06 ,  A61P31/12 ,  A61P35/00 ,  A61P37/04 ,  A61Q19/00 ,  C07H1/00 ,  C07H1/08 ,  C12P19/60 ,  G01N33/5055

Abstract: An icariside compound as shown in Formula I wherein the compound is a natural chemical component in the traditional Chinese herbal epimedium or a chemically modified or a totally synthetic product based on the natural component. The compound can be used for preparing pharmaceuticals, health care products, cosmetic and skin care products and the like for improvement of immunity in a human body.

公开(公告)号：US20180016292A1

公开(公告)日：2018-01-18

申请号：US15544174

申请日：2016-02-02

Applicant: INTERQUIM, S.A.

Inventor： Francisco Javier LÓPEZ CREMADES

IPC: C07H17/07 ,  C07H1/00

CPC classification number: C07H17/07 ,  C07H1/00

Abstract: The present invention relates to a process for the preparation of diosmin from hesperidin. The process involves the oxidation of acylated hesperidin with iodine or bromine in a C2-C4 carboxylic acid medium and subsequent treatment with an inorganic base to partially neutralize the acidic media. The process allows obtaining diosmin with low iodine or bromine content, avoiding the use of organic solvents.

公开(公告)号：US09724361B2

公开(公告)日：2017-08-08

申请号：US14229352

申请日：2014-03-28

Applicant: Korea Food Research Institute

Inventor： In Wook Choi ,  Yong Kon Park ,  Yoon Sook Kim ,  Hee Don Choi ,  Ho Young Park

IPC: A23C9/133 ,  A23L1/30 ,  A61K31/7048 ,  A61K36/752 ,  C07H1/08 ,  C07H17/07 ,  A23L33/105

CPC classification number: A61K31/7048 ,  A23C9/133 ,  A23L33/105 ,  A61K36/752 ,  A61K2236/30 ,  C07H1/08 ,  C07H17/07

Abstract: The present invention relates to a pharmaceutical composition for treating liver diseases, containing a narirutin extract of citrus peel extract or narirutin as an active ingredient. The extract or narirutin decreases cholesterol levels and fat levels in liver tissue, and thus can be utilized as a composition or food for preventing and treating liver diseases. In addition, the present invention relates to a method for extracting narirutin from citrus peel, and a method for preparing citrus fermented milk using the same.

公开(公告)号：US20170081354A1

公开(公告)日：2017-03-23

申请号：US15122708

申请日：2015-03-03

Applicant: Hayashibara Co. Ltd.

Inventor： Mitsuyuki KAMBE ,  Koichi NISHI ,  Akira KAWASHIMA ,  Akiko YASUDA ,  Hitoshi MITSUZUMI ,  Toshio ARIYASU

IPC: C07H17/07 ,  A61K8/60 ,  A61Q19/00 ,  A23L33/15 ,  C12P19/60 ,  A23L27/20 ,  A23L27/00 ,  A23L33/10 ,  A61K31/7048 ,  C12P19/14

Abstract: The present invention aims to provide a novel glycosyl hesperetin, which is significantly reduced in miscellaneous tastes characteristic of conventional products containing glycosyl hesperetin, and a method for producing the same and uses thereof; and the objects are solved by providing a glycosyl hesperetin which comprises glycosyl hesperetin in an amount of 90% or more by mass but less than 100% by mass, on a dry solid basis, but it does not substantially contain furfural, and a method for producing the same and uses thereof.

公开(公告)号：US20170044127A1

公开(公告)日：2017-02-16

申请号：US15113500

申请日：2015-01-23

Applicant: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

Inventor： Sheng Wei ,  Alan List ,  Nicholas Lawrence

IPC: C07D311/30 ,  C07H17/07 ,  C07D239/91

CPC classification number: C07D311/30 ,  C07D239/91 ,  C07D311/62 ,  C07H17/07

Abstract: Disclosed are derivatives of icariin. Disclosed are compounds having Formula I-VIII as defined herein. Methods of using these compounds for the treatment of cancer and inflammation are also disclosed.

Abstract translation: 披露的是淫羊藿苷的衍生物。 公开了具有本文定义的式I-VIII的化合物。 还公开了使用这些化合物治疗癌症和炎症的方法。

公开(公告)号：US09308216B2

公开(公告)日：2016-04-12

申请号：US14389573

申请日：2012-10-22

Applicant: ALPS Pharmaceuticals, IND. Co., Ltd.

Inventor： Kazunobu Minami ,  Shinji Taniwaki ,  Akiko Katsumata

IPC: A61K36/00 ,  A61K31/7048 ,  C07H17/07 ,  A23L1/30 ,  A61K36/74 ,  A61K36/18

CPC classification number: A61K31/7048 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/18 ,  A61K36/74 ,  A61K2236/33 ,  C07H17/07 ,  A23V2200/326 ,  A23V2250/21

Abstract: A method of obtaining a rutin-rich extract from a plant and a rutin-rich extract of Uncaria elliptica thus obtained.

Abstract translation: 从植物获得富含芦丁的提取物的方法和由此获得的胡萝卜素的富含芦丁的提取物。

公开(公告)号：US09079933B2

公开(公告)日：2015-07-14

申请号：US13703220

申请日：2011-06-08

Applicant: Yasushi Yamada ,  Keigo Hanaki ,  Toshiteru Komatsu

Inventor： Yasushi Yamada ,  Keigo Hanaki ,  Toshiteru Komatsu

IPC: C07H17/07 ,  A61K31/05 ,  A61K31/192 ,  A61K31/366 ,  A61K31/7048

CPC classification number: C07H17/07 ,  A61K31/05 ,  A61K31/192 ,  A61K31/366 ,  A61K31/7048 ,  Y02P20/582

Abstract: A method for producing a polyphenol composition including a step of subjecting (A) a hardly water-soluble polyphenol and (B) one or more selected from cathechins, chlorogenic acids and methylated compounds of hardly water-soluble polyphenols to a heat treatment at from 100 to 180° C. in the presence of an aqueous medium.

Abstract translation: 一种多酚组合物的制造方法，其特征在于，包括使（A）几乎不溶于水的多酚和（B）一种或多种选自几何水溶性多酚的导管链，绿原酸和甲基化化合物中的一种以上的热处理 在水介质的存在下为180℃。