公开(公告)号：US20200283466A1

公开(公告)日：2020-09-10

申请号：US16878911

申请日：2020-05-20

Applicant: Hayashibara Co. Ltd.

Inventor： Mitsuyuki KAMBE ,  Koichi NISHI ,  Akira KAWASHIMA ,  Akiko YASUDA ,  Hitoshi MITSUZUMI ,  Toshio ARIYASU

IPC: C07H17/07 ,  A61Q19/00 ,  A61K31/7048 ,  A23L27/00 ,  A23L27/20 ,  A23L33/10 ,  A23L33/15 ,  A61K8/60 ,  C12P19/60 ,  A23L2/52 ,  C12P19/18 ,  C12P19/14

Abstract: The present invention aims to provide a novel glycosyl hesperetin, which is significantly reduced in miscellaneous tastes characteristic of conventional products containing glycosyl hesperetin, and a method for producing the same and uses thereof; and the objects are solved by providing a glycosyl hesperetin which comprises glycosyl hesperetin in an amount of 90% or more by mass but less than 100% by mass, on a dry solid basis, but it does not substantially contain furfural, and a method for producing the same and uses thereof.

公开(公告)号：US20180243195A1

公开(公告)日：2018-08-30

申请号：US15756698

申请日：2016-09-01

Applicant: Hayashibara Co., Ltd.

Inventor： Masaki MIYAKE ,  Motoyuki SUZUKI ,  Tatsuya ISHIHARA ,  Toshio ARIYASU

IPC: A61K8/60 ,  A61K8/49 ,  A61Q19/02 ,  A61K8/365 ,  A61K8/36 ,  A61K8/368

CPC classification number: A61K8/602 ,  A61K8/36 ,  A61K8/365 ,  A61K8/368 ,  A61K8/49 ,  A61K8/498 ,  A61K8/60 ,  A61K9/08 ,  A61K9/16 ,  A61K9/20 ,  A61K31/19 ,  A61K31/198 ,  A61K31/353 ,  A61K31/702 ,  A61K31/7048 ,  A61Q19/00 ,  A61Q19/02

Abstract: [Object] The present invention has an object to provide an external dermal agent for reducing skin yellowness already generated in the skin.[Means to Attain the Object] The above object is solved by providing an external dermal agent for reducing skin yellowness already generated in the skin, which contains hesperetin and/or glycosyl hesperetin as an effective ingredient(s).

公开(公告)号：US20170081354A1

公开(公告)日：2017-03-23

申请号：US15122708

申请日：2015-03-03

Applicant: Hayashibara Co. Ltd.

Inventor： Mitsuyuki KAMBE ,  Koichi NISHI ,  Akira KAWASHIMA ,  Akiko YASUDA ,  Hitoshi MITSUZUMI ,  Toshio ARIYASU

IPC: C07H17/07 ,  A61K8/60 ,  A61Q19/00 ,  A23L33/15 ,  C12P19/60 ,  A23L27/20 ,  A23L27/00 ,  A23L33/10 ,  A61K31/7048 ,  C12P19/14

Abstract: The present invention aims to provide a novel glycosyl hesperetin, which is significantly reduced in miscellaneous tastes characteristic of conventional products containing glycosyl hesperetin, and a method for producing the same and uses thereof; and the objects are solved by providing a glycosyl hesperetin which comprises glycosyl hesperetin in an amount of 90% or more by mass but less than 100% by mass, on a dry solid basis, but it does not substantially contain furfural, and a method for producing the same and uses thereof.

公开(公告)号：US20220031690A1

公开(公告)日：2022-02-03

申请号：US17279760

申请日：2019-09-24

Applicant: Hayashibara Co., Ltd.

Inventor： Hitomi OHTA ,  Satomi MIYATA ,  Takashi MORIMOTO ,  Akira HARASHIMA ,  Toshio ARIYASU

IPC: A61K31/4709

Abstract: The present invention addresses the problem of providing an orally-administrable anti-neurodegenerative disease agent having an action of accelerating neurocyte growth and an action of promoting neurite-outgrowth, and having excellent transfer properties to central nervous tissues. The problem is solved by providing an anti-neurodegenerative disease agent containing a compound represented by General formula 4 as an active ingredient, and having an action of accelerating neurocyte growth, an action of promoting neurite-outgrowth, and an action of scavenging reactive oxygen species. In General formula 4, R10 and R11 represent the same or different alkyl group having 2-8 carbon atoms, and the alkyl group may be either a straight chain or a branched chain. n represents an integer of 0 or 1, and X4− represents a suitable counter anion that is pharmaceutically acceptable.

公开(公告)号：US20210161791A1

公开(公告)日：2021-06-03

申请号：US16071137

申请日：2017-01-19

Applicant: Hayashibara Co., Ltd.

Inventor： Masaki KONO ,  Masahiro FUJIMOTO ,  Yutaka AKAGI ,  Akiko MIYAKE ,  Toshio ARIYASU

IPC: A61K8/60 ,  A23L29/10 ,  A23L3/46 ,  A61K8/02 ,  A61Q19/10 ,  C12P19/12 ,  C12P19/18

Abstract: An object of the present invention is to provide a particulate composition containing crystalline α,α-trehalose dihydrate, having an advantageous emulsifying ability.
The above object is solved by providing a particulate composition comprising crystalline α,α-trehalose dihydrate, which consists of particles containing α,α-trehalose and maltose and/or maltotriose, wherein said particulate composition contains α,α-trehalose in an amount of 70% by weight or higher but 90% by weight or lower, on a dry solid basis; and maltose and/or maltotriose in a total amount of 3% by weight or higher, on a dry solid basis; and has a degree of crystallinity for crystalline α,α-trehalose dihydrate of 25% or higher but less than 90%, when calculated based on its powder X-ray diffraction profile.