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    2-AMINO-BICYCLO(3.1.0) HEXANE-2, 6-DICARBOXYLIC ESTER DERIVATIVE
    5.
    发明申请
    2-AMINO-BICYCLO(3.1.0) HEXANE-2, 6-DICARBOXYLIC ESTER DERIVATIVE 失效
    2-氨基双酚（3.1.0）HEXANE-2，6-二甲氧基硅烷衍生物

    公开(公告)号：US20120004232A1

    公开(公告)日：2012-01-05

    申请号：US13227942

    申请日：2011-09-08

    Applicant: Akito YASUHARA ,  Kazunari SAKAGAMI ,  Hiroshi OHTA ,  Atsuro NAKAZATO

    Inventor： Akito YASUHARA ,  Kazunari SAKAGAMI ,  Hiroshi OHTA ,  Atsuro NAKAZATO

    IPC: A61K31/535 ,  A61K31/27 ,  A61K31/21 ,  A61K31/265 ,  C07C61/13 ,  C07D265/30 ,  C07D317/08 ,  C07D307/87 ,  C07C69/96 ,  C07C271/24 ,  A61K31/365 ,  A61K31/195

    CPC classification number: C07C229/50 ,  C07D307/88

    Abstract: A drug effective for the treatment and prevention of psychiatric disorders such as schizophrenia, anxiety and related ailments thereof, depression, bipolar disorder and epilepsy. The drug antagonizes the action of group II metabotropic glutamate receptors and shows high activity in oral administrationA 2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic ester derivative represented by formula [I] [wherein R1 and R2 are identical or different, and each represents a hydrogen atom, a C1-10alkyl group or the like; X represents a hydrogen atom or a fluorine atom; Y represents —OCHR3R4 or the like (wherein R3 and R4 are identical or different, and each represents a hydrogen atom, a C1-10alkyl group or the like; and n represents integer 1 or 2)], a pharmaceutically acceptable salt thereof or a hydrate thereof.

    Abstract translation: 一种有效治疗和预防精神疾病如精神分裂症，焦虑及其相关疾病，抑郁症，双相情感障碍和癫痫的药物。 该药物拮抗II型代谢型谷氨酸受体的作用，并且在口服给药中表现出高活性。由式[I]表示的2-氨基 - 双环[3.1.0]己烷-2,6-二羧酸酯衍生物[其中R1和R2为 相同或不同，并且各自表示氢原子，C 1-10烷基等; X表示氢原子或氟原子; Y表示-OCHR 3 R 4等（其中R 3和R 4相同或不同，并且各自表示氢原子，C 1-10烷基等; n表示1或2的整数）]，其药学上可接受的盐或 水合物。

    Addition reaction to fluoroallylfluorosulfate
    6.
    发明申请
    Addition reaction to fluoroallylfluorosulfate 有权
    氟代氟代硫酸盐的加成反应

    公开(公告)号：US20100273968A1

    公开(公告)日：2010-10-28

    申请号：US12745869

    申请日：2008-12-17

    Applicant: Giuseppe Marchionni ,  Vito Tortelli

    Inventor： Giuseppe Marchionni ,  Vito Tortelli

    IPC: C08F16/24 ,  C07C41/00 ,  C07D317/08

    CPC classification number: C07D317/42 ,  C07C41/24 ,  C07C51/58 ,  C07C303/24 ,  C08F214/18 ,  C08F259/08 ,  C07C59/135 ,  C07C305/26 ,  C07C43/126

    Abstract: The invention pertains to a process for preparing compounds of formula (I-A) or (I-B) here below: by reaction of perfluoroallylfluorosulfate (FAFS) of formula (II): with at least one hypofluorite of formula (II-A) or (II-B): wherein: RF in formulae (I-A) and (II-A) is a monovalent fluorocarbon C1-C20 group, optionally comprising oxygen catenary atoms, optionally comprising functional groups comprising heteroatoms (e.g. —SO2F groups); R′F in formulae (I-B) and (II-B) is a divalent fluorocarbon C1-C6 group, preferably a group of formula wherein X1 and X2, equal to or different from each other, are independently a fluorine atom or a C1-C3 fluorocarbon group. The FAFS-hypofluorite adducts of formulae (I-A) and (I-B) can be produced with high selectivity so as to access useful intermediates which can further be reacted taking advantage of the un-modified fluorosulfate group chemistry.

    Abstract translation: 本发明涉及如下制备式（IA）或（IB）化合物的方法：通过式（II）的全氟代氟代硫酸盐（FAFS）与至少一种式（II-A）的次氟酸盐或（II- B）：其中：式（IA）和（II-A）中的RF是任选包含氧连接原子的任选包含杂原子的官能团（例如-SO 2 F基团）的单价碳氟化合物C1-C20基团; 式（IB）和（II-B）中的R'F是二价碳氟化合物C1-C6基团，优选下式的基团：其中X1和X2彼此相同或不同，分别为氟原子或C1- C3碳氟化合物。 可以高选择性地制备式（I-A）和（I-B）的FAFS-次氟化物加合物，以便获得可利用未改性的氟硫酸盐基团化学进一步反应的有用的中间体。

    Unsubstituted and polymeric lactone colorants for coloring consumer products
    8.
    发明授权
    Unsubstituted and polymeric lactone colorants for coloring consumer products 有权
    用于着色消费品的未取代和聚合的内酯着色剂

    公开(公告)号：US07544216B2

    公开(公告)日：2009-06-09

    申请号：US12012855

    申请日：2008-02-06

    Applicant: Eduardo Torres ,  Patrick D Moore ,  Joe Clark

    Inventor： Eduardo Torres ,  Patrick D Moore ,  Joe Clark

    IPC: C09B67/02 ,  C07D317/08

    CPC classification number: C07D307/88 ,  C07C217/08 ,  C07C217/76 ,  C07C255/42 ,  C07C309/49 ,  C07D493/10 ,  C09B11/04 ,  C09B11/16 ,  C09B11/18 ,  C09B11/20 ,  C09B11/24 ,  C09B69/00 ,  C11D3/40 ,  D06L4/686 ,  D06P1/004 ,  D06P1/0052 ,  D06P1/227 ,  G01N31/22

    Abstract: This invention relates to unsubstituted and polymeric leuco colorants for use as consumer product additives to indicate a product function by color change, to make attractive or distinctive visual effects, or to provide latent or delayed color generation. The colorants may be present in a stable, colorless state and may be transformed to an intense colored state upon exposure to certain physical or chemical changes. Alternatively, the colorants may be transformed from one color to another color upon exposure to certain physical or chemical changes. The colored form of the unsubstituted or polymeric leuco colorant may be transient, since the colorant can revert back to its colorless form or its original color after the physical or chemical activation has been removed or changed. Polymeric leuco colorants are typically comprised of at least two components: at least one leuco chromophore component and at least one polymeric component.

    Abstract translation: 本发明涉及用作消费品添加剂的未取代和聚合的无色着色剂，以通过颜色变化来表示产品功能，以产生有吸引力或独特的视觉效果，或提供潜在或延迟的颜色产生。 着色剂可以以稳定的无色状态存在，并且在暴露于某些物理或化学变化时可以转变成强烈的着色状态。 或者，当暴露于某些物理或化学变化时，着色剂可以从一种颜色转变成另一种颜色。 未取代的或聚合的无色着色剂的有色形式可能是暂时的，因为在物理或化学活化被去除或改变之后，着色剂可以回复到其无色形式或其原始颜色。 聚合物无色着色剂通常由至少两种组分组成：至少一种无色发色团组分和至少一种聚合物组分。

    PROCESS FOR THE PRODUCTION OF ALKYLENE CARBONATE AND USE OF ALKYLENE CARBONATE THUS PRODUCED IN THE MANUFACTURE OF AN ALKANE DIOL AND A DIALKYL CARBONATE
    9.
    发明申请
    PROCESS FOR THE PRODUCTION OF ALKYLENE CARBONATE AND USE OF ALKYLENE CARBONATE THUS PRODUCED IN THE MANUFACTURE OF AN ALKANE DIOL AND A DIALKYL CARBONATE 有权
    生产亚烷基二醇和碳酸二乙酯生产中生产的亚烷基碳酸酯的方法

    公开(公告)号：US20070197802A1

    公开(公告)日：2007-08-23

    申请号：US11677997

    申请日：2007-02-22

    Applicant: Evert Heide ,  Gerardus Van Kessel ,  Timothy Nisbet ,  Garo Vaporciyan

    Inventor： Evert Heide ,  Gerardus Van Kessel ,  Timothy Nisbet ,  Garo Vaporciyan

    IPC: C07D317/08

    CPC classification number: C07C29/128 ,  C07D317/36 ,  Y02P20/584 ,  C07C31/202

    Abstract: An alkylene carbonate is produced by the reaction of an alkylene oxide with carbon dioxide in the presence of a phosphonium compound as catalyst in a process in which (a) the alkylene oxide, carbon dioxide and the phosphonium catalyst are continuously introduced into a reaction zone from which a product stream containing alkylene carbonate and catalyst is withdrawn, (b) alkylene carbonate and a mixture of alkylene carbonate and phosphonium catalyst are separated from the product stream, (c) the alkylene carbonate, separated in step (b), is recovered as product, and (d) the mixture of alkylene carbonate and phosphonium catalyst is continuously recycled to the reaction zone. The alkylene carbonate thus produced is suitably reacted with an alkanol to produce an alkane diol and a dialkyl carbonate.

    Abstract translation: 在鏻化合物作为催化剂的存在下，通过烯化氧与二氧化碳的反应制备碳酸亚烃酯，其中（a）将环氧烷，二氧化碳和鏻催化剂从 取出含有碳酸亚烃酯和催化剂的产物流，（b）碳酸亚烷基酯和碳酸亚烃酯和鏻催化剂的混合物与产物流分离，（c）将步骤（b）中分离的碳酸亚烃酯回收为 产物，和（d）碳酸亚烷基酯和鏻催化剂的混合物连续循环到反应区。 这样制得的碳酸亚烃酯适当地与烷醇反应生成烷烃二醇和碳酸二烷基酯。

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