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1.
公开(公告)号:US20240092747A1
公开(公告)日:2024-03-21
申请号:US18227186
申请日:2023-07-27
发明人: Denton W. Hoyer , Robert F. Roscow , Rong Ling , Chuanjun Gao
IPC分类号: C07D277/62 , A61K45/06
CPC分类号: C07D277/62 , A61K45/06
摘要: The present invention is directed to novel chemical compositions of matter, and in particular a novel MDMA class of compounds MDMA analogs having 1,3-benzothiazoles substituted at the 5 and 6-position with a MDMA basic or modified side chain.
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公开(公告)号:US20220064112A1
公开(公告)日:2022-03-03
申请号:US17232511
申请日:2021-04-16
发明人: Troy E. Messick , Garry R. Smith , Allen B. Reitz , Paul M. Lieberman , Mark E. McDonnell , Yan Zhang , Marianne Carlsen , Shuai Chen
IPC分类号: C07D209/08 , C07D403/12 , C07D405/14 , C07D401/12 , C07D405/12 , C07D409/12 , C07D487/08 , C07D471/08 , C07D417/12 , A61P35/00 , A61P31/20 , A61K31/404 , A61K31/41 , A61K31/4155 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/435 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K45/06 , C07D277/62 , C07D401/10 , C07D401/14 , C07D403/10 , C07D403/14 , C07D413/10 , C07D417/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107
摘要: The present invention provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by EBNA1 activity, such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and/or rheumatoid arthritis. The present invention further provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection and/or lytic EBV infection.
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公开(公告)号:US10995078B2
公开(公告)日:2021-05-04
申请号:US15929751
申请日:2020-05-20
发明人: Kenneth W. Bair , David R. Lancia, Jr. , Hongbin Li , James Loch , Wei Lu , Matthew W. Martin , David S. Millan , Shawn E. R. Schiller , Mark J. Tebbe
IPC分类号: C07D295/192 , C07D401/04 , C07D403/04 , C07D405/12 , C07D413/12 , A61K31/4965 , A61P35/00 , A61K45/06 , C07D215/14 , C07D231/56 , C07D417/12 , C07D471/04 , C07D257/04 , C07D487/04 , C07D263/57 , C07D491/048 , C07D271/12 , C07D495/04 , C07D209/18 , C07D277/62 , C07D277/66 , C07D513/04 , C07D213/56 , C07D305/08 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/5025 , A61K31/506 , C07D209/08 , C07D213/65 , C07D213/69 , C07D217/16 , C07D231/12 , C07D235/08 , C07D417/04
摘要: The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:
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4.
公开(公告)号:US10730844B2
公开(公告)日:2020-08-04
申请号:US15831735
申请日:2017-12-05
申请人: ZEON CORPORATION
发明人: Kei Sakamoto , Kumi Okuyama
IPC分类号: C07D277/82 , C07C251/82 , C07D277/62 , C07C251/86 , G02B5/30 , C08F222/10 , C09K19/38 , G02B1/111
摘要: A compound which is represented by a formula (IIa), wherein each of Y1 to Y8 independently represents a chemical single bond, —O—, —S—, —O—C(═O)—, —C(═O)—O—, —O—C(═O)—O—, —NR1—C(═O)—, —C(═O)—NR1—, —O—C(═O)—NR1—, —NR1—C(═O)—O—, —NR1—C(═O)—NR1—, —O—NR1—, or —NR1—O—, R1 represents a hydrogen atom or an alkyl group; each of G1 and G2 independently represents a divalent linear aliphatic group; each of Z1 and Z2 independently represents an alkenyl group; Ax represents a group represented by a formula (II), wherein X represents —NR2—, an oxygen atom, a sulfur atom, and R2 represents a hydrogen atom or an alkyl group; D represents an alkylene group or a cycloalkanediyl group; A1 represents a trivalent aromatic group; each of A2 and A3 independently represents a divalent alicyclic hydrocarbon group; each of A4 and A5 independently represents a divalent aromatic group; Q1 represents a hydrogen atom, or an alkyl group.
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公开(公告)号:US10472342B2
公开(公告)日:2019-11-12
申请号:US16383296
申请日:2019-04-12
发明人: Kenneth W. Bair , David R. Lancia, Jr. , Hongbin Li , James Loch , Wei Lu , Matthew W. Martin , David S. Millan , Shawn E. R. Schiller , Mark J. Tebbe
IPC分类号: C07D295/192 , A61K31/4965 , A61P35/00 , C07D401/04 , C07D403/04 , C07D405/12 , C07D413/12 , C07D417/04 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D213/65 , C07D213/69 , C07D213/56 , C07D231/12 , C07D235/08 , C07D209/08 , C07D209/18 , C07D263/57 , C07D277/66 , C07D277/62 , C07D271/12 , C07D513/04 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K45/06 , C07D217/16 , A61K31/5025 , A61K31/506 , C07D305/08 , C07D257/04 , C07D417/12 , C07D231/56 , C07D215/14
摘要: The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:
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公开(公告)号:US10399951B2
公开(公告)日:2019-09-03
申请号:US16119962
申请日:2018-08-31
发明人: Kenneth W. Bair , David R. Lancia, Jr. , Hongbin Li , James Loch , Wei Lu , Matthew W. Martin , David S. Millan , Shawn E. R. Schiller , Mark J. Tebbe
IPC分类号: C07D295/192 , A61K31/4965 , A61P35/00 , C07D401/04 , C07D403/04 , C07D405/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D491/048 , C07D495/04 , C07D213/65 , C07D213/69 , C07D213/56 , C07D231/12 , C07D235/08 , C07D209/08 , C07D209/18 , C07D263/57 , C07D271/12 , C07D277/66 , C07D277/62 , C07D513/04 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K45/06 , C07D215/14 , C07D231/56 , C07D257/04 , C07D487/04 , C07D305/08 , A61K31/5025 , A61K31/506 , C07D217/16
摘要: The present invention relates to compounds and compositions for inhibition of FASN, their synthesis, applications, and antidotes.
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7.
公开(公告)号:US20180093958A1
公开(公告)日:2018-04-05
申请号:US15831735
申请日:2017-12-05
申请人: ZEON CORPORATION
发明人: Kei SAKAMOTO , Kumi OKUYAMA
IPC分类号: C07D277/82 , G02B1/111 , C09K19/38 , C07D277/62 , G02B5/30 , C07C251/86 , C07C251/82 , C08F222/10
CPC分类号: C07D277/82 , C07C251/82 , C07C251/86 , C07D277/62 , C08F222/1006 , C09K19/3838 , G02B1/111 , G02B5/30
摘要: A compound represented by a formula (IIa) is provided. In formula (IIa), Y1 to Y8 represent —O—, —S—, —O—C(═O)—, —C(═O)—O— or the like, G1 and G2 represent a divalent linear aliphatic group having 1 to 20 carbon atoms or the like, Z1 and Z2 represent an alkenyl group having 2 to 10 carbon atoms or the like, Ax represents a group represented by a formula (II), wherein X represents an oxygen atom, a sulfur atom or the like, D represents an alkylene group having 1 to 20 carbon atoms or the like, A1 represents a trivalent aromatic group or the like, A2 and A3 represent a divalent alicyclic hydrocarbon group having 3 to 30 carbon atoms or the like, A4 and A5 represent a divalent aromatic group having 4 to 30 carbon atoms or the like, Q1 represents an alkyl group having 1 to 6 carbon atoms or the like, and m and n are 0 or 1.
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公开(公告)号:US09745328B2
公开(公告)日:2017-08-29
申请号:US14765556
申请日:2014-01-31
发明人: Genesis M. Bacani , Wendy Eccles , Anne E. Fitzgerald , Steven D. Goldberg , Michael D. Hack , Natalie A. Hawryluk , William M. Jones , John M. Keith , Paul Krawczuk , Alec D. Lebsack , Alice Lee-Dutra , Jing Liu , Kelly J. McClure , Steven P. Meduna , Daniel J. Pippel , Mark D. Rosen , Zachary S. Sales
IPC分类号: C07F7/08 , C07D491/107 , C07D491/08 , C07D405/12 , C07D403/14 , A61K31/422 , A61K31/55 , A61K31/506 , C07D403/10 , C07D237/20 , C07D409/12 , C07D413/10 , C07D241/20 , C07D241/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D487/04 , C07D405/14 , C07D413/14 , C07D213/73 , C07D401/04 , C07D235/10 , C07D401/10 , C07D417/10 , C07D471/04 , C07D487/08 , C07D263/48 , C07D491/10 , C07D498/04 , C07D209/08 , C07D277/62 , C07D285/12 , C07F5/02 , C07D495/10
CPC分类号: C07F7/0812 , C07D209/08 , C07D213/73 , C07D235/10 , C07D237/20 , C07D241/20 , C07D241/26 , C07D263/48 , C07D277/62 , C07D285/12 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/10 , C07D491/107 , C07D495/10 , C07D498/04 , C07F5/025 , C07F7/08
摘要: The present invention relates to compounds of Formula (I), or a form thereof wherein ring A1, R1, R2, R3, R3′, L, W, and V are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.
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公开(公告)号:US20170158648A1
公开(公告)日:2017-06-08
申请号:US15332599
申请日:2016-10-24
发明人: Weirong CHEN , Michael HUMORA , Daw-Iong Albert KWOK , William F. KIESMAN , Erwin Ayandra IRDAM
IPC分类号: C07D277/82 , C07D277/62
CPC分类号: C07D277/82 , C07D277/62
摘要: The present invention is related to an improved process for the preparation of amino-substituted 4,5,6,7-tetrahydrobenzothiazole compounds of formula I, such as the compound 2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention further relates to an improved synthesis of (R)-2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention also relates to the methods and intermediates associated with the synthetic process.
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公开(公告)号:US09617259B2
公开(公告)日:2017-04-11
申请号:US14776320
申请日:2014-03-10
发明人: Celia Dominguez , Ignacio Muñoz-Sanjuán , Michel Maillard , Christopher A. Luckhurst , Rebecca E. Jarvis , Roland W. Bürli , Daniel R. Allen , Alan F. Haughan , Perla Breccia , Huw D. Vater , Andrew J. Stott , Stephen D. Penrose , Michael Wall , Elizabeth A. Saville-Stones , Grant Wishart , Samantha J. Hughes
IPC分类号: C07D471/04 , C07D277/64 , C07D241/12 , C07D213/64 , C07C259/08 , C07D277/62 , C07D261/20 , C07D275/04 , C07D333/60 , C07D213/56 , C07D213/61 , C07D239/26 , C07D241/42 , C07D231/12 , C07D231/56
CPC分类号: C07D471/04 , C07C259/08 , C07C2601/02 , C07C2601/10 , C07D213/56 , C07D213/61 , C07D213/64 , C07D231/12 , C07D231/56 , C07D239/26 , C07D241/12 , C07D241/42 , C07D261/20 , C07D275/04 , C07D277/62 , C07D277/64 , C07D333/60
摘要: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
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