专利检索 ap:("KNOPP BIOSCIENCES LLC") AND inv:"Michael HUMORA" 第 1 页

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发明申请
SYNTHESIS OF AMINE SUBSTITUTED 4,5,6,7-TETRAHYDROBENZOTHIAZOLE COMPOUNDS 审中-公开

公开(公告)号：US20170158648A1

公开(公告)日：2017-06-08

申请号：US15332599

申请日：2016-10-24

申请人： KNOPP BIOSCIENCES LLC

发明人： Weirong CHEN , Michael HUMORA , Daw-Iong Albert KWOK , William F. KIESMAN , Erwin Ayandra IRDAM

IPC分类号： C07D277/82 , C07D277/62

CPC分类号： C07D277/82 , C07D277/62

摘要： The present invention is related to an improved process for the preparation of amino-substituted 4,5,6,7-tetrahydrobenzothiazole compounds of formula I, such as the compound 2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention further relates to an improved synthesis of (R)-2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention also relates to the methods and intermediates associated with the synthetic process.