公开(公告)号：US20240199564A1

公开(公告)日：2024-06-20

申请号：US18546560

申请日：2022-02-16

申请人： Concentric Analgesics, Inc.

发明人： Craig HUSFELD

IPC分类号： C07D295/135 ,  A61K31/166 ,  A61K31/40 ,  A61K31/4465 ,  A61K31/451 ,  A61K31/472 ,  A61K31/4965 ,  A61K31/5375 ,  C07C233/62 ,  C07C235/10 ,  C07C237/10 ,  C07D211/46 ,  C07D213/40 ,  C07D217/02 ,  C07D295/185

CPC分类号： C07D295/135 ,  A61K31/166 ,  A61K31/40 ,  A61K31/4465 ,  A61K31/451 ,  A61K31/472 ,  A61K31/4965 ,  A61K31/5375 ,  C07C233/62 ,  C07C235/10 ,  C07C237/10 ,  C07D211/46 ,  C07D213/40 ,  C07D217/02 ,  C07D295/185 ,  C07C2601/16

摘要： Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate transient receptor potential melastatin 8 receptor (TRPM8) activity.

公开(公告)号：US20230242481A1

公开(公告)日：2023-08-03

申请号：US18009877

申请日：2020-06-15

申请人： Zhejiang Tianyu Pharmaceutical Co., Ltd.

发明人： Zhen Wang ,  Chunlong Ke ,  Junfeng Liu ,  Peng Zhang ,  Qichao Li ,  Guorong Zhu ,  Yongjun Tu

IPC分类号： C07D207/12 ,  C07C237/10

CPC分类号： C07D207/12 ,  C07C237/10

摘要： Provided is a preparation method for brivaracetam. The method has a synthetic route as shown below. The preparation method for the brivaracetam is simple, economical, environmentally friendly and suitable for industrialization:

公开(公告)号：US20230100647A1

公开(公告)日：2023-03-30

申请号：US17794322

申请日：2021-01-07

申请人： DAICEL CORPORATION

发明人： Hiroyuki FUJII

IPC分类号： C07C215/10 ,  C07C237/10 ,  C07C291/04

摘要： Provided is a composition having moderate viscosity for coating properties and ejection properties, being applicable for firing at low temperatures, and leaving an extremely small amount of ash after firing. The composition of the present disclosure contains a miscible material of a compound represented by Formula (1) below and a compound (A) represented by Formula (A) below. In Formula (1) below, R1 represents a linear aliphatic hydrocarbon group having from 10 to 25 carbons; R2 and R3 are identical or different and represent an aliphatic hydrocarbon group having 2, 4, 6, or 8 carbons; R4 represents an aliphatic hydrocarbon group having from 1 to 8 carbons; R5 and R6 are identical or different and represent an aliphatic hydrocarbon group having from 1 to 3 carbons or a hydroxyalkyl ether group; and L1 to L3 represent an amide bond. In Formula (A) below, in the formula, Ra and Rc are identical or different and represent a hydrogen atom or an aliphatic hydrocarbon group that has from 1 to 12 carbons and may have a substituent; Rb represents an aliphatic hydrocarbon group that has from 1 to 12 carbons and may have a substituent; and the substituents are each an amino group and/or a hydroxyl group.

公开(公告)号：US20220363976A1

公开(公告)日：2022-11-17

申请号：US17861360

申请日：2022-07-11

申请人： ChampionX USA Inc.

发明人： Jeremy Wayne Bartels ,  Jeffrey M. Servesko

IPC分类号： C09K8/524 ,  C07C237/10 ,  C07D223/04 ,  C09K8/52

摘要： Disclosed are alkyl lactone-derived hydroxyamides and alkyl lactone-derived hydroxyesters used in compositions and methods for inhibiting natural gas hydrate agglomerates. The alkyl lactone-derived hydroxyamides and alkyl lactone-derived hydroxyesters are reaction products of an alkyl lactone and an amine, and an alkyl lactone and an alcohol, respectively.

公开(公告)号：US11414588B2

公开(公告)日：2022-08-16

申请号：US16507873

申请日：2019-07-10

申请人： ChampionX USA Inc.

发明人： Jeremy Wayne Bartels ,  Jeffrey M. Servesko

IPC分类号： C09K8/524 ,  C07C237/10 ,  C09K8/52 ,  C07D223/04

摘要： Disclosed are alkyl lactone-derived hydroxyamides and alkyl lactone-derived hydroxyesters used in compositions and methods for inhibiting natural gas hydrate agglomerates. The alkyl lactone-derived hydroxyamides and alkyl lactone-derived hydroxyesters are reaction products of an alkyl lactone and an amine, and an alkyl lactone and an alcohol, respectively.

公开(公告)号：US20210347949A1

公开(公告)日：2021-11-11

申请号：US17382452

申请日：2021-07-22

申请人： Alliance for Sustainable Energy, LLC

发明人： Tao DONG ,  Lieve M.L. LAURENS ,  Philip T. PIENKOS ,  Paris Fabian SPINELLI

IPC分类号： C08G71/04 ,  C07C269/04 ,  C07C271/16 ,  C07C271/20 ,  C07C237/10 ,  C07C237/20 ,  C07C237/22 ,  C07C279/12

摘要： The present disclosure relates to methods for producing polymers and resins, the method including a first reacting of at least a first diamine with a first carbonate-containing compound and a second carbonate-containing compound to produce at least one of the polymer or the resin, where the first reacting is according to each of R1, R2, R3, and R4 include at least one of a hydrogen atom, a methyl group, a saturated hydrocarbon chain, and/or an unsaturated hydrocarbon chain, and R comprises at least one of a carbon atom, a saturated hydrocarbon chain, and/or an unsaturated hydrocarbon chain.

公开(公告)号：US10435616B2

公开(公告)日：2019-10-08

申请号：US15522906

申请日：2015-10-30

申请人： Ecolab USA Inc.

发明人： Rebecca Michele Lucente-Schultz ,  Jeff Servesko

IPC分类号： C09K8/52 ,  C07C237/06 ,  C07C237/10

摘要： This disclosure relates to anti-agglomerant low dosage hydrate inhibitors that can inhibit the formation of hydrate agglomerants and/or plugs. The anti-agglomerant low dosage hydrate inhibitors can be surfactants. The hydrate inhibitors can be used for inhibiting, retarding, mitigating, reducing, controlling and/or delaying formation of hydrocarbon hydrates, agglomerants of hydrates, and/or plugs. The hydrate inhibitors can be applied to prevent, reduce, and/or mitigate plugging of conduits, pipes, transfer lines, valves, and other places or equipment where hydrocarbon hydrate solids can form. The hydrate inhibitors can be zwitterionic or cationic ammonium surfactants.

公开(公告)号：US10358411B2

公开(公告)日：2019-07-23

申请号：US15781493

申请日：2016-12-29

申请人： Samyang Biopharmaceuticals Corporation

发明人： Sungwon Choi ,  Hye Yeong Nam ,  Min-Hyo Seo

IPC分类号： C07C237/10 ,  C07C231/02 ,  C07C237/06 ,  C07C231/12

摘要： Disclosed is a method capable of selectively synthesizing cationic lipids by controlling the introduction rate of a fatty acid group with respect to an oligoalkyleneamine by the change of reaction conditions.

公开(公告)号：US20190092721A1

公开(公告)日：2019-03-28

申请号：US16205637

申请日：2018-11-30

申请人： UNIVERSITE DE LILLE 2 DROIT ET SANTE ,  CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU)

发明人： Patricia Melnyk ,  Patrick Vermersch ,  Pascal Carato ,  Bénédicte Oxombre-Vanteghem ,  Héléne Zephir ,  Marion Donnier-Marechal

IPC分类号： C07C233/78 ,  C07D209/44 ,  A61K49/00 ,  C07C237/10 ,  C07C255/60 ,  C07D209/08 ,  C07C237/34 ,  C07C255/57 ,  C07C235/50 ,  C07C211/29 ,  C07C211/27 ,  C07C311/37 ,  C07C237/20

摘要： The present invention is directed to novel compounds of Formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.

公开(公告)号：US10172846B2

公开(公告)日：2019-01-08

申请号：US15470599

申请日：2017-03-27

申请人： Medivir AB

发明人： Asa Rosenquist ,  Fredrik Thorstensson ,  Per-Ola Johansson ,  Ingemar Kvarnstrom ,  Bertil Samuelsson ,  Hans Wallberg

IPC分类号： A61K31/47 ,  C07C235/40 ,  C07C237/04 ,  C07C237/10 ,  C07C247/04 ,  C07C271/22 ,  C07C281/02 ,  C07C309/73 ,  C07C311/51 ,  C07D207/16 ,  C07D215/233 ,  C07D245/04 ,  C07D401/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D487/04 ,  C07K5/02 ,  C07K5/062 ,  C07D215/20

摘要： Methods drawn to peptidomimetic compounds which inhibit the NS3 protease of the hepatitis C virus (HCV), are described. The compounds have the formula (VI) where the variable definitions are as provided in the specification. The compounds comprise a carbocyclic P2 unit in conjunction with a novel linkage to those portions of the inhibitor more distal to the nominal cleavage site of the native substrate, which linkage reverses the orientation of peptidic bonds on the distal side relative to those proximal to the cleavage site.