公开(公告)号：US10807958B2

公开(公告)日：2020-10-20

申请号：US16009979

申请日：2018-06-15

申请人： INSERM (Institut National de la Sante et de la Recherche Medicale) ,  CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU) ,  UNIVERSITE DE LILLE 2 DROIT ET SANTE

发明人： Nicolas Sergeant ,  Luc Buee ,  Patricia Melnyk ,  Marion Gay ,  Nicolas Le Fur

IPC分类号： C07D219/12

摘要： The present invention relates to the compound having Formula (I) or pharmaceutically acceptable salts or solvates thereof, and its use in treating and/or preventing a Tauopathy.

公开(公告)号：US20190381036A1

公开(公告)日：2019-12-19

申请号：US16552436

申请日：2019-08-27

申请人： ALZPROTECT ,  UNIVERSITE DE LILLE 2 DROIT ET SANTE ,  INSERM (Institut National de la Santé et de la Recherche Médicale)

发明人： Stéphane BURLET ,  Cécilia ESTRELLA ,  Mathieu BARRIER ,  Patricia MELNYK ,  Nicolas SERGEANT ,  Luc BUEE ,  Philippe VERWAERDE

IPC分类号： A61K31/496 ,  A61P25/28 ,  C07D235/30 ,  A61K9/00

摘要： The present invention relates to sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof, preparation thereof, pharmaceutical compositions containing them and use of the same in the treatment and/or prevention of neurodegenerative diseases.

公开(公告)号：US20190099448A1

公开(公告)日：2019-04-04

申请号：US16087471

申请日：2017-03-23

申请人： CENTRE HOSPITALER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU) ,  UNIVERSITE DE LILLE 2 DROIT ET SANTE ,  UNIVERSITE DU LITTORAL COTE D'OPALE ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  TAIPEI MEDICAL UNIVERSITY

发明人： David DEVOS ,  Thierry BURNOUF ,  Jean-christophe DEVEDJIAN ,  Ming-Li CHOU

IPC分类号： A61K35/19 ,  A61P25/28 ,  A61P25/16

摘要： A process for preparing a modified heat-treated platelet pellet lysate, said process comprising the steps of: a) Providing a platelet pellet lysate, b) Heat-treating the platelet pellet lysate at a temperature of 55° C. to 65° C. during 20 to 40 minutes, c) Purifying the heat-treated platelet pellet lysate of step b) so as to obtain a modified heat treated platelet pellet lysate having a total protein content of less than 70% of the total protein content of the platelet pellet lysate of step a).

公开(公告)号：US20190022034A1

公开(公告)日：2019-01-24

申请号：US16138286

申请日：2018-09-21

申请人： CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU) ,  UNIVERSITE DE LILLE 2 DROIT ET SANTE ,  UNIVERSITE DU LITTORAL COTE D'OPALE

发明人： David Devos ,  Caroline Moreau ,  Charlotte Laloux ,  Jean-Christophe Devedjian

IPC分类号： A61K31/137 ,  A61K9/00

摘要： The present invention is directed to pharmaceutical solution comprising at least dopamine for use in treating Parkinson's disease, wherein said pharmaceutical solution is kept under anaerobic conditions from its formulation to its administration.

公开(公告)号：US20180008723A1

公开(公告)日：2018-01-11

申请号：US15545163

申请日：2016-01-21

申请人： UNIVERSITE DES SCIENCES ET TECHNOLOGIES DE LILLE-LILLE 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT PASTEUR DE LILLE ,  UNIVERSITE DE LILLE 2 DROIT ET SANTE ,  UNIVERSITA' DEGLI STUDI DI PAVIA

发明人： Jerome VICOGNE ,  Oleg MELNYK ,  Nathalie OLLIVIER ,  Eric ADRIAENSSENS ,  Berenice LECLERCQ ,  Claire SIMONNEAU ,  Giovanni DE NOLA ,  Ermanno GHERARDI ,  Hugo DE JONGE

IPC分类号： G01N33/58 ,  A61K38/18 ,  A61K49/00 ,  G01N33/50

CPC分类号： A61K47/665 ,  A61K38/00 ,  A61K38/1833 ,  A61K47/557 ,  A61K49/0002 ,  C07K14/4753 ,  G01N33/502 ,  G01N33/5023 ,  G01N33/582

摘要： Disclosed are multimeric compounds of K1 domains from the Hepatocyte Growth Factor/Scatter Factor (HGF/SF) being able to induce activation of the tyrosine kinase receptor MET and their uses.

公开(公告)号：US20170151193A1

公开(公告)日：2017-06-01

申请号：US15310364

申请日：2015-05-12

申请人： CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU) ,  UNIVERSITE DE LILLE 2 DROIT ET SANTE ,  UNIVERSITE DU LITTORAL COTE D'OPALE

发明人： David Devos ,  Caroline Moreau ,  Charlotte Laloux ,  Jean-christophe Devedjian

IPC分类号： A61K31/137 ,  A61K9/00

CPC分类号： A61K31/137 ,  A61K9/0019 ,  A61K9/0085

摘要： The present invention is directed to pharmaceutical solution comprising at least dopamine for use in treating Parkinson's disease, wherein said pharmaceutical solution is kept under anaerobic conditions from its firmation to its administration.

公开(公告)号：US20170107174A1

公开(公告)日：2017-04-20

申请号：US15317742

申请日：2015-06-15

申请人： UNIVERSITE DE LILLE 2 DROIT ET SANTE ,  CENTER HOSPITALIER REGIONAL ET UNIVERSITARE DE LILLE (CHRU)

发明人： Patricia Melnyk ,  Patrick Vermersch ,  Pascal Carato ,  Bénédicte Oxombre-Vanteghem ,  Hélène Zephir ,  Marion Donnier-Marechal

IPC分类号： C07C233/78 ,  C07D209/44 ,  C07C235/50 ,  C07C211/29 ,  C07C255/57 ,  C07C237/10 ,  C07C255/60 ,  C07C311/37 ,  A61K49/00 ,  C07C237/34

CPC分类号： C07C233/78 ,  A61K49/00 ,  C07C211/27 ,  C07C211/29 ,  C07C235/50 ,  C07C237/10 ,  C07C237/20 ,  C07C237/34 ,  C07C255/57 ,  C07C255/60 ,  C07C311/37 ,  C07D209/08 ,  C07D209/44

摘要： The present invention is directed to novel compounds of Formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.

公开(公告)号：US10561856B2

公开(公告)日：2020-02-18

申请号：US15025623

申请日：2014-11-25

申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE DE LILLE 2 DROIT ET SANTE ,  CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU)

发明人： Serge Mordon ,  Nacim Betrouni ,  Laurent Mortier

IPC分类号： A61N5/06

摘要： The system comprises: —a bundle of light fibers (11) connected to a light-emitting source (8), and both transmitting light inside the light fiber and emitting light toward a treatment volume (V), —a temperature-modifying system attached to the bundle of light fibers (11) to modify temperature in the treatment volume (V).

公开(公告)号：US10323016B2

公开(公告)日：2019-06-18

申请号：US15315270

申请日：2015-06-11

申请人： UNIVERSITE DE LILLE 2 DROIT ET SANTE ,  INSTITUT PASTEUR DE LILLE ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)

发明人： Julie Charton ,  Benoit Deprez ,  Florence Leroux ,  Bart Staels ,  Anne Muhr-Tailleux ,  Nathalie Hennuyer ,  Sophie Lestavel ,  Manuel Lassalle ,  Barbara Dubanchet

IPC分类号： C07D403/12 ,  C07D401/12 ,  C07D233/88 ,  C07D249/14

摘要： The present invention is directed to novel compounds of formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.

公开(公告)号：US20190033525A1

公开(公告)日：2019-01-31

申请号：US16074937

申请日：2017-02-03

申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE DE LILLE 2 DROIT ET SANTE ,  CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU)

发明人： Serge MORDON ,  Pascal DELEPÔRTE ,  Nacim BETROUNI

IPC分类号： G02B6/14 ,  H04B10/2581

CPC分类号： G02B6/14 ,  H04B10/2581

摘要： An optical fiber mode scrambler adapted to give a determined bending to an optical fiber inserted in the mode scrambler, the mode scrambler having a general extension direction X, the mode scrambler having a morphology adapted to give the optical fiber a direction along X at the entry of the scrambler, and then to bend the fiber to bring the fiber substantially in the X, Y plan in the −X and Y directions, before bringing the fiber in a rotation around the X axis substantially in the Y, Z plan in the anti clockwise direction for one full rotation, and then bending the fiber to bring the fiber substantially in the X, Y plan in the −X and −Y directions, and then bending the fiber to give the optical fiber a direction along X at the exit of the scrambler.