公开(公告)号：US5608112A

公开(公告)日：1997-03-04

申请号：US499932

申请日：1995-07-10

申请人： Jeffrey Schwartz

发明人： Jeffrey Schwartz

IPC分类号： C07C209/36 ,  C07C209/42 ,  C07C209/30 ,  C07C1/26

CPC分类号： C07C209/42 ,  C07C209/36 ,  Y10S210/909

摘要： Nitrogen-containing substituents of aliphatic or aromatic compounds can be reduced by treatment with a reagent comprising (i) at least one complex of a transition metal of group 4 or 5 with a multidentate or unidentate organic or inorganic ligand and (ii) a reducing agent. The reaction is conducted optionally in the presence of an aliphatic or aromatic amine, and/or in the presence of an inert organic solvent.

摘要翻译： 脂肪族或芳族化合物的含氮取代基可以通过用包含（i）至少一种第4或5族的过渡金属的络合物与多齿或无齿的有机或无机配体和（ii）还原剂 。 反应任选在脂族或芳族胺存在下，和/或在惰性有机溶剂的存在下进行。

公开(公告)号：US20090082599A1

公开(公告)日：2009-03-26

申请号：US11859377

申请日：2007-09-21

申请人： Elizabeth Burkhardt ,  Alex J. Attlesey ,  Christopher P. Sutton ,  Karl Matos

发明人： Elizabeth Burkhardt ,  Alex J. Attlesey ,  Christopher P. Sutton ,  Karl Matos

IPC分类号： C07C209/30 ,  C07C209/24 ,  C07C29/136

CPC分类号： C07C29/147 ,  C07C29/143 ,  C07C209/48 ,  C07C209/50 ,  C07C209/52 ,  C07C31/12 ,  C07C33/22

摘要： In a process for the accelerated reduction of organic substrates, selected from the group consisting of esters, amides, nitriles, acids, ketones, imines or mixtures thereof, they are reacted with an amine borane, sulfide borane or ether borane complex as a borane source in the presence of organic accelerator compounds containing either Lewis acidic or Lewis basic sites in their structure, of which the Lewis acidic site can coordinate with the carbonyl or nitrile or imine group of the substrate or the Lewis basic site can coordinate with the borane.

摘要翻译： 在加速还原有机底物的方法中，选自酯，酰胺，腈，酸，酮，亚胺或其混合物，它们与胺硼烷，硫化硼烷或醚硼烷络合物作为硼烷源反应 在其结构中含有路易斯酸性或路易斯碱性位点的有机促进剂化合物的存在下，其中路易斯酸性位点可以与底物的羰基或腈或亚胺基团或路易斯碱性位点配位，可与硼烷配位。

公开(公告)号：US07109378B2

公开(公告)日：2006-09-19

申请号：US10053787

申请日：2002-01-21

申请人： Keith Allen Welp ,  Anthony Rocco Cartolano ,  David Joseph Parrillo ,  Richard Peter Boehme ,  Reinaldo Mario Machado ,  Sylvia Caram

发明人： Keith Allen Welp ,  Anthony Rocco Cartolano ,  David Joseph Parrillo ,  Richard Peter Boehme ,  Reinaldo Mario Machado ,  Sylvia Caram

IPC分类号： C07C209/30 ,  C07C209/32 ,  C07C209/34 ,  C07C209/48 ,  C07C209/52

CPC分类号： B01F5/0643 ,  B01J19/0053 ,  B01J19/2485 ,  B01J35/04 ,  C07C209/36 ,  Y02P20/582

摘要： The invention pertains to an improved apparatus comprised of a monolith catalytic reactor having an inlet and an outlet and a static mixer having an inlet and an outlet thereto with the outlet of said static mixer in communication with the inlet of said monolith catalytic reactor. The invention also pertains to an improvement in a process for effecting a reaction in the monolith catalytic reactor wherein a reactant gas and reactant liquid are introduced to the inlet to the monolith catalytic reactor, reacted and, then, the reaction product passed through the outlet of the monolith catalytic reactor.

公开(公告)号：US5382691A

公开(公告)日：1995-01-17

申请号：US147619

申请日：1993-11-05

申请人： Michael K. Stern ,  Brian K-M. Cheng

发明人： Michael K. Stern ,  Brian K-M. Cheng

IPC分类号： B01J31/02 ,  C07B61/00 ,  C07C209/00 ,  C07C209/02 ,  C07C209/30 ,  C07C209/42 ,  C07C209/68 ,  C07C211/45 ,  C07C211/54 ,  C07C211/55 ,  C07C245/08 ,  C07C309/45 ,  C07C209/24

CPC分类号： C07C209/68 ,  C07C209/00

摘要： A process for preparing substituted aromatic amines is provided which comprises contacting a substituted aromatic azo compound and an alcohol selected from the group consisting of aliphatic alcohols, cycloaliphatic alcohols, arylalkyl alcohols and mixtures thereof in the presence of a suitable base at a temperature of about 70.degree. C. to about 200.degree. C. In another embodiment, the substituted aromatic amines of the invention are reductively alkylated to produce alkylated diamines or substituted derivatives thereof.

摘要翻译： 提供了一种制备取代的芳族胺的方法，其包括在合适的碱存在下，在约70℃的温度下使取代的芳族偶氮化合物和选自脂族醇，脂环族醇，芳烷基醇及其混合物的醇 在另一个实施方案中，本发明的取代的芳族胺被还原烷基化以产生烷基化的二胺或其取代的衍生物。

公开(公告)号：US20180086691A9

公开(公告)日：2018-03-29

申请号：US15411863

申请日：2017-01-20

申请人： AQUINOX PHARMACEUTICALS (CANADA) INC.

发明人： Curtis Harwig ,  Jeyaprakashnarayanan Seenisamy ,  Mahesh Narayan Keregadde ,  Lakshindra Chetia

IPC分类号： C07C209/30

CPC分类号： C07C209/30 ,  C07B2200/07 ,  C07C213/00 ,  C07C249/12 ,  C07C2101/14 ,  C07C2102/02 ,  C07C2601/14 ,  C07C2602/02 ,  C07C2602/24 ,  C07D307/77 ,  C07D317/70 ,  C07D317/72 ,  C07J1/0011 ,  C07J1/0022 ,  C07J13/007 ,  C07J21/008 ,  C07J31/006 ,  C07J51/00 ,  C07J71/0026 ,  C07J73/003 ,  C07J73/005 ,  C07C215/42

摘要： This invention is directed to methods of preparing AQX-1125 having the formula: This invention is also directed to intermediates utilized in the methods of preparing AQX-1125.

公开(公告)号：US20100197954A1

公开(公告)日：2010-08-05

申请号：US12440285

申请日：2007-09-05

申请人： Hao Yang ,  Lanny S. Liebeskind

发明人： Hao Yang ,  Lanny S. Liebeskind

IPC分类号： C07C68/06 ,  C07C209/30

CPC分类号： C07C213/02 ,  C07C269/06 ,  C07C215/24 ,  C07C271/16

摘要： Embodiments of the present disclosure provide for methods of making sphingosines and derivatives thereof, and the like.

摘要翻译： 本公开的实施方案提供了制备鞘氨醇及其衍生物的方法等。

公开(公告)号：US5929282A

公开(公告)日：1999-07-27

申请号：US39547

申请日：1998-03-16

申请人： Ken Sendelsky ,  Brent S. DeFeo ,  Russell W. Johnson ,  Subramaniam E. Haran ,  Alexander M. Bershitsky ,  Martin Andren ,  John Yamanis

发明人： Ken Sendelsky ,  Brent S. DeFeo ,  Russell W. Johnson ,  Subramaniam E. Haran ,  Alexander M. Bershitsky ,  Martin Andren ,  John Yamanis

IPC分类号： A62D3/00 ,  A62D3/37 ,  A62D101/06 ,  A62D101/26 ,  A62D101/45 ,  C01C1/02 ,  C07C209/30 ,  C07C211/04 ,  C07C211/06 ,  C01C1/00 ,  C07C211/00

CPC分类号： A62D3/37 ,  C01C1/02 ,  C01C1/026 ,  C07C209/30 ,  A62D2101/06 ,  A62D2101/26 ,  A62D2101/45 ,  A62D2203/10 ,  Y02P20/52

摘要： An apparatus and method for converting hydrazine, substituted hydrazines and/or other nitrogen-containing explosive materials, particularly unsymmetric dimethyl hydrazine (UDMH), to ammonia or ammonia and the corresponding amines by hydrogenation are disclosed. The hydrazines are diluted with a suitable carrier fluid, preferably water, mixed with hydrogen, then hydrogenated in a catalyst reactor, followed by separation of the commercially valuable ammonia and amines. Separated carrier fluid and hydrogen gas may be recycled in to the process to conserve energy and reduce waste. Recycled carrier fluid may be used to preheat the diluted hydrazine prior to hydrogenation. Ammonia may be dissociated and the resultant hydrogen recycled into the hydrogenation process. The apparatus is sized for disassembly and transport for shipping to hydrazine disposal sites.

摘要翻译： 公开了将肼，取代的肼和/或其它含氮的爆炸性材料，特别是不对称的二甲基肼（UDMH）转化成氨或氨以及通过氢化的相应的胺的装置和方法。 将肼用合适的载体流体稀释，优选水与氢气混合，然后在催化剂反应器中氢化，然后分离商业上有价值的氨和胺。 分离的载体流体和氢气可以循环到该过程中以节省能量并减少浪费。 再循环的载体流体可以用于在氢化之前预热稀释的肼。 氨可能被解离并且所产生的氢再循环到氢化过程中。 该设备的尺寸适于拆卸和运输以运送到肼处理场。

公开(公告)号：US5166444A

公开(公告)日：1992-11-24

申请号：US848390

申请日：1992-03-09

申请人： Klaus Hutchmacher ,  Hermann Schmitt

发明人： Klaus Hutchmacher ,  Hermann Schmitt

IPC分类号： C07C209/30 ,  C07C209/48 ,  C07C211/36 ,  C07C255/61

CPC分类号： C07C255/61 ,  C07C209/30 ,  C07C209/48 ,  C07C2101/14

摘要： The invention relates to bis(3-cyano-3,5,5-trimethylcyclohexylidene)-azine (=IPN-azine), a method of its preparation by reacting 1,3,3-trimethyl-5-oxocyclohexane carbonitrile (=IPN) with a source for hydrazine in a molar ratio of essentially 2 to 1 in the presence of a solvent and to a method for the further processing of the IPN-azine to 3-(aminomethyl)-3,5,5-trimethylcyclohexyl amine (isophorone diamine=IPDA) by means of a hydrogenating azine splitting with hydrogen in the presence of an organic solvent, ammonia and of a catalytic system from the series (a) of a cobalt- or nickel-containing Raney catalyst and of a cocatalyst from the series of salts of the elements aluminum, cobalt, nickel, yttrium, lanthanum, cerium, Ru, Rh, Pd, Ir and Pt or of carrier-supported noble metals from the series Ru, Rh, Pd, Ir, Pt or b) of a carrier-supported Ru-, Pd- or Pt catalyst at a pressure of 3 to 30 MPa and a temperature of 50.degree. to 150.degree. C. The method of the invention concerning IPN-azine makes it possible to obtain IPDA from IPN in high yield and purity and avoids disadvantages of the previously known reductive amination of IPN.

摘要翻译： 本发明涉及双（3-氰基-3,5,5-三甲基亚环己基）嗪（= IPN-吖嗪），其制备方法为1,3,3-三甲基-5-氧代环己烷腈（= IPN） 其中在溶剂存在下，摩尔比基本为2:1的肼源和用于将IPN-吖嗪进一步加工成3-（氨基甲基）-3,5,5-三甲基环己胺（异佛尔酮）的方法 二胺= IPDA）通过在有机溶剂，氨和来自含钴或镍的阮内催化剂系列（a）的催化体系和来自该系列的助催化剂的一系列催化体系 的元素铝，钴，镍，钇，镧，铈，Ru，Rh，Pd，Ir和Pt的元素或载体负载的贵金属由Ru，Rh，Pd，Ir，Pt或b） 载体负载的Ru-，Pd-或Pt催化剂，压力为3〜30MPa，温度为50〜150℃。本发明涉及IPN-吖嗪mak 可以以高产率和纯度从IPN获得IPDA，并避免以前已知的IPN还原胺化的缺点。

公开(公告)号：US4474987A

公开(公告)日：1984-10-02

申请号：US365131

申请日：1982-04-05

申请人： Bruno Wollemann ,  Hartmut Hartner ,  Hans Bardonner

发明人： Bruno Wollemann ,  Hartmut Hartner ,  Hans Bardonner

IPC分类号： C07C311/08 ,  C07C67/00 ,  C07C209/00 ,  C07C209/30 ,  C07C209/38 ,  C07C211/50 ,  C07C213/00 ,  C07C213/02 ,  C07C215/16 ,  C07C217/08 ,  C07C217/18 ,  C07C301/00 ,  C07C303/22 ,  C07C303/36 ,  C07C309/14 ,  C07C311/32 ,  C07C85/11

CPC分类号： C07C209/02 ,  C07C303/40

摘要： A process for preparing an N,N-disubstituted p-phenylenediamine of the formula ##STR1## wherein R.sup.1 is alkyl of 1-6 C atoms, R.sup.2 is alkyl of 1-6 C atoms or alkyl of 1-6 C atoms which is substituted by OH, lower alkoxy, a sulfo group or an alkylsulfonamido group and R.sup.3 is hydrogen or lower alkylor an acid addition salt thereof,comprises adding an alkyl nitrite, as a nitrosation agent,to an aqueous, acid suspension of the corresponding aniline derivative of the formula ##STR2## thereby forming the corresponding N,N-disubstituted p-nitroso-aniline, and subsequently hydrogenating the latter without isolation thereof from the reaction mixture.

摘要翻译： 制备下式的N，N-二取代的对苯二胺的方法，其中R 1是1-6个C原子的烷基，R 2是1-6个碳原子的烷基或被取代的1-6个C原子的烷基 通过OH，低级烷氧基，磺基或烷基磺酰胺基，R 3是氢或低级烷基或其酸加成盐，包括将亚硝酸烷基酯作为亚硝化剂加入到相应的苯胺衍生物的 从而形成相应的N，N-二取代对亚硝基苯胺，随后将其氢化，而不从反应混合物中分离。

公开(公告)号：US10053415B2

公开(公告)日：2018-08-21

申请号：US15411863

申请日：2017-01-20

申请人： AQUINOX PHARMACEUTICALS (CANADA) INC.

发明人： Curtis Harwig ,  Jeyaprakashnarayanan Seenisamy ,  Mahesh Narayan Keregadde ,  Lakshindra Chetia

IPC分类号： C07C209/30

CPC分类号： C07C209/30 ,  C07B2200/07 ,  C07C213/00 ,  C07C249/12 ,  C07C2601/14 ,  C07C2602/02 ,  C07C2602/24 ,  C07D307/77 ,  C07D317/70 ,  C07D317/72 ,  C07J1/0011 ,  C07J1/0022 ,  C07J13/007 ,  C07J21/008 ,  C07J31/006 ,  C07J51/00 ,  C07J71/0026 ,  C07J73/003 ,  C07J73/005 ,  C07C215/42

摘要： This invention is directed to methods of preparing AQX-1125 having the formula: This invention is also directed to intermediates utilized in the methods of preparing AQX-1125.