公开(公告)号：US12233228B2

公开(公告)日：2025-02-25

申请号：US18478290

申请日：2023-09-29

Applicant: Nine Medical, Inc.

Inventor： Ryan Kendall Pierce ,  Benjamin Kahn Cline

IPC: A61M31/00 ,  A61M11/00 ,  B05B11/00

Abstract: Methods and devices to affect types, proportion, quantity, distribution, or proliferation of microorganisms within a female reproductive system.

公开(公告)号：US20250062642A1

公开(公告)日：2025-02-20

申请号：US18610992

申请日：2024-03-20

Applicant: The Board of Trustees of The Leland Stanford Junior University

Inventor： Daniel Michael Pivonka ,  Anatoly Anatolievich Yakovlev ,  Ada Shuk Yan Poon ,  Teresa H. Meng

IPC: H02J50/10 ,  A61B1/00 ,  A61B5/07 ,  A61M25/01 ,  A61M31/00 ,  H02J7/34 ,  H02J50/23 ,  H02J50/27 ,  H02J50/80 ,  H02J50/90

Abstract: Described is a locomotive implant for usage within a predetermined magnetic field. In one embodiment magnetohydrodynamics is used to generate thrust with a plurality of electrodes. In another embodiment, asymmetric drag forces are used to generate thrust.

公开(公告)号：US20250050081A1

公开(公告)日：2025-02-13

申请号：US18810246

申请日：2024-08-20

Applicant: Rani Therapeutics, LLC

Inventor： Mir IMRAN ,  Paul SPEHR

IPC: A61M31/00 ,  A61M39/08 ,  A61M39/22

Abstract: A delivery assembly for an ingestible device to deliver a fluid preparation into a GI lumen wall or surrounding tissue of a subject includes a housing, a piston, a needle, a conduit, and a valve member. The housing defines a piston chamber. The piston is movably disposed in the piston chamber. The needle is coupled to, or integrally formed with, the piston. The conduit is structured to direct the fluid preparation from a fluid source to the needle. The valve member has a first state and a second state. In the first state, the valve member substantially impedes a flow of the fluid preparation from the conduit to the needle. In the second state, the valve member is structured to allow the fluid preparation to flow through the conduit to the needle.

公开(公告)号：US20250032782A1

公开(公告)日：2025-01-30

申请号：US18427620

申请日：2024-01-30

Applicant: Oculeve, Inc.

Inventor： Douglas Michael Ackermann ,  James Donald Loudin

IPC: A61N1/05 ,  A61F7/12 ,  A61H1/00 ,  A61H9/00 ,  A61H21/00 ,  A61H23/02 ,  A61M31/00 ,  A61N1/04 ,  A61N1/36 ,  A61N1/378 ,  A61N7/00 ,  H02J7/00

Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.

公开(公告)号：US20250032327A2

公开(公告)日：2025-01-30

申请号：US17998674

申请日：2021-05-25

Applicant: Tonia PRICE

Inventor： Tonia PRICE

IPC: A61F13/26 ,  A61M31/00

Abstract: The present invention is directed to delivery device for deploying an insertable into an orifice guided by digit, the delivery device comprising: insertable orientation means adapted to orient the insertable in a deployment orientation and digit orientation means adapted to orient a portion of at least one digit in a navigation orientation, the insertable orientation means and the digit orientation means adjoined across a partition with a partition cross-section, and the deployment orientation and the navigation orientation arranged for digit guided deployment of the insertable into the orifice. Also disclosed is a method of deploying an insertable into an orifice guided by digit, using the delivery device of the present invention. The delivery device and method of the present invention are well suited to deploying tampons into the vaginal cavity.

公开(公告)号：US20250025675A1

公开(公告)日：2025-01-23

申请号：US18711339

申请日：2022-11-18

Applicant: Atmo Biosciences Limited

Inventor： James JOHN ,  Malcolm HEBBLEWHITE ,  Kyle BEREAN ,  William KENTLER ,  Mark KIDDER ,  Spencer Terry WOOD

IPC: A61M31/00

Abstract: Embodiments include an ingestible capsule comprising a housing including a therapeutic payload carrying compartment; a power supply; a release mechanism; and a sensing mechanism, the sensing mechanism being sensitive to an environment external to the housing; the ingestible capsule being configured for passage through a GI tract of a subject mammal, during which passage: the sensing mechanism is configured to output a signal varying according to a GI tract environment, wherein the sensing mechanism comprises one or more sensors from among: a VOC gas sensor; a TCD gas sensor; a reflectometer formed by a transmission antenna of the ingestible capsule connected in series with a directional coupler configured to measure a reflected signal from the transmission antenna; and an accelerometer; the release mechanism is configured to cause a therapeutic payload to be released into the GI tract from the therapeutic payload carrying compartment at a release timing determined according to the output signal.

公开(公告)号：US20250017783A1

公开(公告)日：2025-01-16

申请号：US18898266

申请日：2024-09-26

Applicant: Moldex-Metric, Inc.

Inventor： Mark Magidson ,  James Hornstein ,  Fred Ryan

IPC: A61F11/08 ,  A61F11/12 ,  A61L31/16 ,  A61M31/00 ,  A61M35/00

Abstract: A foam earplug for reception at least partially within the ear canal and including a body portion formed of resilient foam plastic material having a multiple open cell structure and having a size and shape for at least partial reception within the ear canal. A transdermal material having a particular beneficial action, and with an outer layer of the foam earplug infused with the transdermal material so that the benefits of the transdermal material is in transdermal contact with the ear canal. One example is a humectant material and, specifically, a moisturizer/lubricating material, for providing an increase to the lubrication and moisturizing in the ear canal. A second example is where the beneficial action is provided by systemic distribution such as a sleep aid, i.e., Melatonin, so that when the earplugs are worn during sleep, the earplugs will provide a sleep aid to the wearer.

公开(公告)号：US20250001148A1

公开(公告)日：2025-01-02

申请号：US18274106

申请日：2022-01-27

Applicant: Novo Nordisk A/S

Inventor： Noekkvi Steinn Sigurdarson ,  Finn Hougaard

IPC: A61M31/00

Abstract: A capsule device (100) suitable for ingestion for travelling into a lumen of the gastrointestinal tract of a patient, the lumen having a lumen wall, wherein the capsule device (100) is configured as a self-righting capsule comprising: a) a capsule housing (110, 120) comprising a compartment and an exterior tissue engaging surface (123) defining an exit opening (124) leading from the compartment to the capsule exterior, b) a tissue penetrating member (130) arranged along an axis and configured to be advanced axially from a first position in the compartment through the exit opening (124) and into the lumen wall at a target location, and c) an actuator (140, 150) for coupling to the tissue penetrating member (130), the actuator (140, 150) configured, upon actuation, to move from the a first configuration to a second configuration thereby advancing the tissue penetrating member (130) axially from the first position and into the lumen wall, wherein the actuator (140, 150) comprises a spring (140) formed as a tapered helical tension spring, the spring (140) having a wide first end coupled to the capsule housing (110, 120) and a narrow second end that couples to the tissue penetrating member (130), wherein, in the first configuration, accumulated tension in the spring (140) is maintained, and wherein, upon actuation, accumulated tension in the spring (140) is released thereby moving the actuator (140, 150) towards the second configuration.

公开(公告)号：US20240408361A1

公开(公告)日：2024-12-12

申请号：US18699199

申请日：2022-10-28

Applicant: Biograil APS

Inventor： Nikolaj Skak ,  Karsten Lindhardt ,  Kamille Majken Dumong Erichsen

IPC: A61M31/00

Abstract: A drug delivery device comprising a central axis extending from a first longitudinal end of the drug delivery device to a second longitudinal end of the drug delivery device, a first body part, a second body part, an attachment part connected to the first body part, and an actuator mechanism configured to rotate one of the first body part and/or the second body part, wherein the actuator mechanism is located more towards the first longitudinal end than the second longitudinal end along the central axis.

公开(公告)号：US20240399126A1

公开(公告)日：2024-12-05

申请号：US18800665

申请日：2024-08-12

Applicant: Spiral Therapeutics Inc.

Inventor： Kevin W. Sacherman ,  Signe Erickson ,  Hugo Peris ,  Eugene de Juan, JR.

IPC: A61M31/00 ,  A61M37/00

Abstract: An implantable device for delivering a therapeutic agent to treat an ear of a patient includes a body having a distal end region and a proximal end region. The body defines, at least in part, a reservoir configured to contain the therapeutic agent. The device includes a shaft attached to the distal end region of the body and a lumen extending through the shaft having at least one inlet at a proximal end region in fluid communication with the reservoir and at least one outlet at a distal end region. Upon implantation of the body in a region of the ear, a length of the shaft is sufficient to extend from the body to at least the round window membrane of the ear. The device is configured to deliver the therapeutic agent to the ear from the reservoir via passive diffusion. Related devices and methods are described.