公开(公告)号：US20240350485A1

公开(公告)日：2024-10-24

申请号：US18700089

申请日：2022-10-12

申请人： TARIS Biomedical LLC

发明人： Srinivas MAMIDI ,  Karen DANIEL ,  Dennis GIESING ,  Philip Erna H HEYNS ,  Jens Julien Maurits André DHONDT ,  Urbain Alfons C DELAET

IPC分类号： A61K31/498 ,  A61J3/10 ,  A61K9/00 ,  A61K9/20 ,  A61M31/00 ,  A61P35/00

CPC分类号： A61K31/498 ,  A61J3/10 ,  A61K9/0034 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/2095 ,  A61M31/002 ,  A61P35/00 ,  A61M2210/1085

摘要： Provided herein are solid pharmaceutical compositions comprising erdafitinib, processes for making such formulations, and drug delivery systems comprising such formulations, including systems for intravesical administration.

公开(公告)号：US12115330B2

公开(公告)日：2024-10-15

申请号：US17419187

申请日：2020-01-02

申请人： VIBRANT LTD.

发明人： Lior Ben-Tsur ,  Shai Molnar ,  Ronny Shabbat

IPC分类号： A61M31/00 ,  A61B5/00 ,  A61B5/07 ,  A61K9/00 ,  A61M37/00

CPC分类号： A61M31/002 ,  A61B5/0051 ,  A61B5/073 ,  A61B5/42 ,  A61B5/4839 ,  A61B5/6861 ,  A61K9/0053 ,  A61M31/00 ,  A61M37/00 ,  A61B2562/162 ,  A61M2205/3306 ,  A61M2205/3327 ,  A61M2205/3341 ,  A61M2205/3344 ,  A61M2205/3368 ,  A61M2205/8206 ,  A61M2210/1053 ,  A61M2210/106 ,  A61M2210/1064

摘要： Devices and methods for delivering an ingestible medicament of a medicament tablet into the gastrointestinal tract of a user. A device according to the invention includes a vibrating ingestible capsule and a hollow medicament compartment housing. The vibrating capsule includes a housing, a vibrating agitation mechanism disposed within the housing, a power supply, and a control element. The hollow medicament compartment housing is associated with the housing of the capsule and includes at least one aperture. The hollow of the medicament compartment housing is configured to have the medicament tablet disposed therein. The aperture(s) are dimensioned to enable fluid communication the surrounding environment and the hollow.

公开(公告)号：US12115252B2

公开(公告)日：2024-10-15

申请号：US18588938

申请日：2024-02-27

申请人： Cristcot LLC

发明人： Jennifer J. Davagian ,  Raj Devarajan

IPC分类号： A61K9/02 ,  A61K9/00 ,  A61K31/573 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/20 ,  A61M31/00

CPC分类号： A61K9/025 ,  A61K9/0031 ,  A61K9/02 ,  A61K31/573 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/20 ,  A61M31/007 ,  A61M2210/1064 ,  A61M2210/1067

摘要： The present invention relates, in various embodiments, to formulations comprising hydrocortisone and silicon dioxide. In additional embodiments, the invention relates to suppositories comprising hydrocortisone and silicon dioxide. The formulations of the present invention are useful for administration to patients who have gastrointestinal diseases and disorders such as, for example, inflammatory bowel disease.

公开(公告)号：US12115251B2

公开(公告)日：2024-10-15

申请号：US18588820

申请日：2024-02-27

申请人： Cristcot LLC

发明人： Jennifer J. Davagian ,  Raj Devarajan

IPC分类号： A61K9/02 ,  A61K9/00 ,  A61K31/573 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/20 ,  A61M31/00

CPC分类号： A61K9/025 ,  A61K9/0031 ,  A61K9/02 ,  A61K31/573 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/20 ,  A61M31/007 ,  A61M2210/1064 ,  A61M2210/1067

摘要： The present invention relates, in various embodiments, to formulations comprising hydrocortisone and silicon dioxide. In additional embodiments, the invention relates to suppositories comprising hydrocortisone and silicon dioxide. The formulations of the present invention are useful for administration to patients who have gastrointestinal diseases and disorders such as, for example, inflammatory bowel disease.

公开(公告)号：US12102784B2

公开(公告)日：2024-10-01

申请号：US17474961

申请日：2021-09-14

申请人： Heraeus Medical GmbH

发明人： Sebastian Vogt ,  Thomas Kluge

IPC分类号： A61M31/00 ,  A61M5/178 ,  A61M5/32

CPC分类号： A61M31/002 ,  A61M5/1782 ,  A61M5/3286 ,  A61M2205/0216

摘要： The invention relates to an implant for local active ingredient release having an upper wall (1), which is closed and disk-shaped and consists of a material which is pierceable with an injection cannula using a force of less than 100 N, is self-sealing and is elastically deformable, a lower wall (2) which is arranged opposite the upper wall (1), is disk-shaped, is elastically deformable and has at least one liquid-permeable feed-through (3) through the lower wall (2), a hollow space (4) which is arranged between the upper wall (1) and the lower wall (2), and an anti-piercing means (6), which is disk-shaped, between the upper wall (1) and the lower wall (2), wherein the anti-piercing means (6) consists of a material which is not pierceable with an injection cannula (100) using a force of less than 100 N.
The invention also relates a method for filling such an implant with a liquid.

公开(公告)号：US20240316324A1

公开(公告)日：2024-09-26

申请号：US18260865

申请日：2022-01-28

申请人： Biograil APS

发明人： Nikolaj Skak ,  Karsten Lindhardt ,  Kamille Majken Dumong Erichsen

IPC分类号： A61M31/00

CPC分类号： A61M31/002

摘要： A drug delivery device having a central axis, the drug delivery device comprising a first body part, a second body part, an actuator mechanism configured to rotate at least one of the first body part or the second body part with respect to one another about the central axis, and a first attachment part comprising a connector component and a first spike component, the connector component connected to the first body part and the first spike component releasably connected to the connector component.

公开(公告)号：US12097091B1

公开(公告)日：2024-09-24

申请号：US17236870

申请日：2021-04-21

申请人： Justin Stack ,  Seok Won Yoon ,  Giuseppe Massara

发明人： Justin Stack ,  Seok Won Yoon ,  Giuseppe Massara

IPC分类号： B29C33/38 ,  A61F11/08 ,  A61M31/00

CPC分类号： A61F11/08 ,  A61M31/007 ,  B29C33/3857 ,  A61M2210/0668

摘要： An oto-block applicator, includes a plunger, an oto-block holder configured to couple to the plunger; and an insertion stop coupled to said oto-block holder, wherein the insertion stop is configured to prevent insertion of the oto-block holder past a predetermined distance into the ear, and the plunger is configured to push an oto-block held within the oto-block holder out of a front end of the oto-block holder and into the user's ear.

公开(公告)号：US20240299715A1

公开(公告)日：2024-09-12

申请号：US18593968

申请日：2024-03-03

申请人： HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

发明人： Quanliang Cao ,  Yuxuan Sun ,  Liang Li ,  Wang Zhang ,  Enmin Song

IPC分类号： A61M31/00 ,  A61M39/22

CPC分类号： A61M31/002 ,  A61M39/22 ,  A61M2039/226 ,  A61M2205/0272 ,  A61M2205/50 ,  A61M2207/00

摘要： The disclosure belongs to the technical field of capsule robotics, and in particular, relates to a magnetically driven capsule robot with controllable drug administration and sampling functions and a fabrication method thereof. A magnetically driven capsule robot provided by the disclosure includes a robot body and a magnetic field-driven control module. The robot body includes a capsule shell, two ends of the capsule shell are provided with hollow air chambers, and a carrier chamber is disposed between the hollow air chambers disposed on the two ends. A substance transfer channel, a magnetic lock disposed around the substance transfer channel, and a magnetic soft switch valve matched with the magnetic lock are disposed on a side wall of the carrier chamber. The soft valve automatically closes due to the magnetic attraction force between the lock and valve, and can be flexibly opened under a magnetic torque acting on the valve.

公开(公告)号：US12082994B2

公开(公告)日：2024-09-10

申请号：US18520400

申请日：2023-11-27

申请人： Moldex-Metric, Inc.

发明人： Mark Magidson ,  James Hornstein ,  Fred Ryan

IPC分类号： A61F11/08 ,  A61M31/00 ,  A61F11/12 ,  A61L31/16 ,  A61M35/00

CPC分类号： A61F11/08 ,  A61M31/002 ,  A61F11/085 ,  A61F11/12 ,  A61L31/16 ,  A61M35/00 ,  A61M2210/0662

摘要： A foam earplug for reception at least partially within the ear canal and including a body portion formed of resilient foam plastic material having a multiple open cell structure and having a size and shape for at least partial reception within the ear canal. A transdermal material having a particular beneficial action, and with an outer layer of the foam earplug infused with the transdermal material so that the benefits of the transdermal material is in transdermal contact with the ear canal. One example is a humectant material and, specifically, a moisturizer/lubricating material, for providing an increase to the lubrication and moisturizing in the ear canal. A second example is where the beneficial action is provided by systemic distribution such as a sleep aid, i.e., Melatonin, so that when the earplugs are worn during sleep, the earplugs will provide a sleep aid to the wearer.

公开(公告)号：US20240245891A1

公开(公告)日：2024-07-25

申请号：US18425471

申请日：2024-01-29

申请人： Cochlear Limited

发明人： Wolfram Frederik DUECK ,  Daniel SMYTH

IPC分类号： A61M31/00 ,  A61N1/05

CPC分类号： A61M31/00 ,  A61N1/0541 ,  A61M2205/05 ,  A61M2210/0668

摘要： An apparatus including a therapeutic substance delivery device configured for attachment to a first tissue area internal of a recipient, the delivery device configured to enable movement of a therapeutic substance outlet of the delivery device proximate a second tissue area away from the first tissue area after attachment to the first tissue area to deliver the therapeutic substance from the outlet while implanted in the recipient.