公开(公告)号：US20250025675A1

公开(公告)日：2025-01-23

申请号：US18711339

申请日：2022-11-18

Applicant: Atmo Biosciences Limited

Inventor： James JOHN ,  Malcolm HEBBLEWHITE ,  Kyle BEREAN ,  William KENTLER ,  Mark KIDDER ,  Spencer Terry WOOD

IPC: A61M31/00

Abstract: Embodiments include an ingestible capsule comprising a housing including a therapeutic payload carrying compartment; a power supply; a release mechanism; and a sensing mechanism, the sensing mechanism being sensitive to an environment external to the housing; the ingestible capsule being configured for passage through a GI tract of a subject mammal, during which passage: the sensing mechanism is configured to output a signal varying according to a GI tract environment, wherein the sensing mechanism comprises one or more sensors from among: a VOC gas sensor; a TCD gas sensor; a reflectometer formed by a transmission antenna of the ingestible capsule connected in series with a directional coupler configured to measure a reflected signal from the transmission antenna; and an accelerometer; the release mechanism is configured to cause a therapeutic payload to be released into the GI tract from the therapeutic payload carrying compartment at a release timing determined according to the output signal.

公开(公告)号：US20240389883A1

公开(公告)日：2024-11-28

申请号：US18703173

申请日：2022-10-21

Applicant: ATMO BIOSCIENCES LIMITED

Inventor： James JOHN ,  Kyle BEREAN ,  Malcolm HEBBLEWHITE ,  Adam CHRIMES ,  Eduardo Rath ROHR ,  Spencer Terry WOOD

IPC: A61B5/07 ,  A61B5/00 ,  A61B5/06

Abstract: A method of determining a location of an ingestible capsule within a gastrointestinal tract of a subject mammal, the method comprising providing the ingestible capsule to the subject mammal for ingestion, the ingestible capsule comprising a housing, a power source, a TCD gas sensor, and a VOC gas sensor; recording readings of the ingestible capsule as a function of time, the readings including TCD gas sensor readings and VOC gas sensor readings; processing the recorded readings, including: determining a timing of a gastric-duodenal transition, wherein determining the timing comprises detecting a gastric-duodenal transition indicator in recorded readings including the recorded TCD gas sensor readings; and determining a timing of a transition across an ileocecal junction by the ingestible capsule, wherein determining the timing comprises detecting an ileocecal junction indicator in recorded readings including the VOC gas sensor readings.