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公开(公告)号：US20240252796A1
公开(公告)日：2024-08-01
申请号：US18566555
申请日：2022-06-09
Applicant: Novo Nordisk A/S
Inventor： Noekkvi Steinn Sigurdarson
IPC: A61M31/00
CPC classification number: A61M31/002
Abstract: A self-righting ingestible capsule comprising: a) a capsule housing (110, 120) defining a central axis and having proximal and distal ends, b) a sealing compartment (A) within the capsule housing (110, 120) accommodating a solid dose member (130), and comprising a distal exit port (124), c) an actuation compartment (B) fluidically isolated from the scaling compartment (A), d) an actuation member (150) at least partially accommodated in the actuation compartment (B) and arranged for axial displacement thereby moving the dose member (130) distally through the distal exit port (124), e) a helical spring (140) for powering the actuation member (150) in a distal direction, f) a latch component (152) coupled to the actuation member (150) for releasably maintaining the actuation member latched in a proximal position, and g) a dissolvable latch support (160) disposed in the actuation compartment (B), wherein the dissolvable latch support maintains latching of the actuation member (150) in the proximal position by supporting the latch component
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公开(公告)号：US20240307670A1
公开(公告)日：2024-09-19
申请号：US18273388
申请日：2022-01-27
Applicant: Novo Nordisk A/S
Inventor： Noekkvi Steinn Sigurdarson
IPC: A61M31/00
CPC classification number: A61M31/002
Abstract: A capsule device (100), comprising: a) a capsule housing (110, 120) having proximal and distal ends and defining a main axis, the capsule housing comprising a plurality of retainer portions (113a) distributed around the main axis, and b) an actuation mechanism (140, 150) operable between a pre-actuation configuration and an actuating configuration, wherein the actuation mechanism (140, 150) comprises: b1) an actuation member (150) configured for axial distal movement, the actuation member (150) comprising a base portion (151) and a plurality of radially deflectable latch arms (153) extending proximally therefrom, wherein each latch arm (153) defines a radially inwards facing latch surface (153b) being inclined with respect to the axis and a radially outwards facing latch surface (153a) in retaining engagement with a respective retainer portion (113a) of the capsule housing (110, 120), b2) a drive spring (140) exerting mechanical load onto the actuation member (150) for driving the actuation member axially in the distal direction, and b3) a dissolvable latch support (160) having radially outwards facing surfaces (163b) being inclined relative to the axis, wherein the dissolvable latch support (160) is arranged centrally on-axis and wherein the plurality of radially deflectable latch arms (163) are distributed around the main axis so that each latch arm (163) is releasably retained radially between a respective one of said inclined outwards facing surfaces (163b) of the dissolvable latch support (160) and a respective one the retainer portions (113a).
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Patent Agency Ranking
公开(公告)号：US20210154406A1
公开(公告)日：2021-05-27
申请号：US16769068
申请日：2018-12-04
Applicant: Novo Nordisk A/S
Inventor： Noekkvi Steinn Sigurdarson , Nicolai Michael Jensen
Abstract: The present invention concerns a drug delivery device (1) comprising: a housing (2) extending along a main axis, a torsion spring (5) comprising a first spring end (4) arranged stationarily with respect to the housing (2) and a second spring end (6) capable of rotation about the main axis, a rotatable shaft (80) extending along the main axis, the rotatable shaft (80) having a non-self-locking thread (81) and being axially fixed with respect to the housing (2), a spring end retainer (82) to which the second spring end (6) is attached, the spring end retainer (82) being rotationally fixed relative to the rotatable shaft (80), and a nut member (45) engaged with the non-self-locking thread (81), the nut member (45) being axially movable by translation relative to the housing (2) to thereby travel the non-self-locking thread (81) between a first position in which the torsion spring (5) is in a relaxed state and a second position in which the torsion spring (5) is in a strained state.
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公开(公告)号：US20200368435A1
公开(公告)日：2020-11-26
申请号：US16765268
申请日：2018-11-20
Applicant: Novo Nordisk A/S
Inventor： Noekkvi Steinn Sigurdarson , Nicolai Michael Jensen
Abstract: The present invention provides a power unit (1) for a drug delivery device as well as methods for providing and mounting the power unit (1) in the drug delivery device. The power unit (1) comprises a first interface member (30) extending along a reference axis and comprising a hollow body (31) and a first engagement structure (35), a second interface member (10) comprising a tubular structure (11) extending at least partially through the hollow body (31) and having a skirt (12), and a second engagement structure (14) configured for releasable engagement with the first engagement structure (35), and a torsion spring (20) comprising a first end portion (23) being attached to the first interface member (30) and a second end portion (22) being attached to the second interface member (10), the torsion spring (20) being pre-strained to induce a relative rotational motion between the first interface member (30) and the second interface member (10). The first interface member (30) and the second interface member (10) are configured for relative motion along the reference axis from a first relative axial position in which the first engagement structure (35) and the second engagement structure (14) are engaged to prevent the relative rotational motion between the first interface member (30) and the second interface member (10) to a second relative axial position in which the first engagement structure (35) and the second engagement structure (14) are disengaged. In the first relative axial position of the first interface member (30) and the second interface member (10) the torsion spring (20) is accommodated in a user inaccessible space (39) defined by the hollow body (31) and the skirt (12).
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公开(公告)号：US20250001148A1
公开(公告)日：2025-01-02
申请号：US18274106
申请日：2022-01-27
Applicant: Novo Nordisk A/S
Inventor： Noekkvi Steinn Sigurdarson , Finn Hougaard
IPC: A61M31/00
Abstract: A capsule device (100) suitable for ingestion for travelling into a lumen of the gastrointestinal tract of a patient, the lumen having a lumen wall, wherein the capsule device (100) is configured as a self-righting capsule comprising: a) a capsule housing (110, 120) comprising a compartment and an exterior tissue engaging surface (123) defining an exit opening (124) leading from the compartment to the capsule exterior, b) a tissue penetrating member (130) arranged along an axis and configured to be advanced axially from a first position in the compartment through the exit opening (124) and into the lumen wall at a target location, and c) an actuator (140, 150) for coupling to the tissue penetrating member (130), the actuator (140, 150) configured, upon actuation, to move from the a first configuration to a second configuration thereby advancing the tissue penetrating member (130) axially from the first position and into the lumen wall, wherein the actuator (140, 150) comprises a spring (140) formed as a tapered helical tension spring, the spring (140) having a wide first end coupled to the capsule housing (110, 120) and a narrow second end that couples to the tissue penetrating member (130), wherein, in the first configuration, accumulated tension in the spring (140) is maintained, and wherein, upon actuation, accumulated tension in the spring (140) is released thereby moving the actuator (140, 150) towards the second configuration.
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公开(公告)号：US11648351B2
公开(公告)日：2023-05-16
申请号：US16765268
申请日：2018-11-20
Applicant: Novo Nordisk A/S
Inventor： Noekkvi Steinn Sigurdarson , Nicolai Michael Jensen
CPC classification number: A61M5/2033 , A61M5/31585 , A61M5/31593 , A61M5/348 , A61M5/31525 , A61M5/31533 , A61M5/31565 , A61M5/31576 , A61M2005/2013 , A61M2005/31588
Abstract: The present invention provides a power unit (1) for a drug delivery device as well as methods for providing and mounting the power unit (1) in the drug delivery device. The power unit (1) comprises a first interface member (30) extending along a reference axis and comprising a hollow body (31) and a first engagement structure (35), a second interface member (10) comprising a tubular structure (11) extending at least partially through the hollow body (31) and having a skirt (12), and a second engagement structure (14) configured for releasable engagement with the first engagement structure (35), and a torsion spring (20) comprising a first end portion (23) being attached to the first interface member (30) and a second end portion (22) being attached to the second interface member (10), the torsion spring (20) being pre-strained to induce a relative rotational motion between the first interface member (30) and the second interface member (10). The first interface member (30) and the second interface member (10) are configured for relative motion along the reference axis from a first relative axial position in which the first engagement structure (35) and the second engagement structure (14) are engaged to prevent the relative rotational motion between the first interface member (30) and the second interface member (10) to a second relative axial position in which the first engagement structure (35) and the second engagement structure (14) are disengaged. In the first relative axial position of the first interface member (30) and the second interface member (10) the torsion spring (20) is accommodated in a user inaccessible space (39) defined by the hollow body (31) and the skirt (12).
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公开(公告)号：US11633540B2
公开(公告)日：2023-04-25
申请号：US16769068
申请日：2018-12-04
Applicant: Novo Nordisk A/S
Inventor： Noekkvi Steinn Sigurdarson , Nicolai Michael Jensen
Abstract: The present invention concerns a drug delivery device (1) comprising: a housing (2) extending along a main axis, a torsion spring (5) comprising a first spring end (4) arranged stationarily with respect to the housing (2) and a second spring end (6) capable of rotation about the main axis, a rotatable shaft (80) extending along the main axis, the rotatable shaft (80) having a non-self-locking thread (81) and being axially fixed with respect to the housing (2), a spring end retainer (82) to which the second spring end (6) is attached, the spring end retainer (82) being rotationally fixed relative to the rotatable shaft (80), and a nut member (45) engaged with the non-self-locking thread (81), the nut member (45) being axially movable by translation relative to the housing (2) to thereby travel the non-self-locking thread (81) between a first position in which the torsion spring (5) is in a relaxed state and a second position in which the torsion spring (5) is in a strained state.
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