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公开(公告)号：US20220249815A1
公开(公告)日：2022-08-11
申请号：US17668090
申请日：2022-02-09
Applicant: SPIRAL THERAPEUTICS, INC.
Inventor： Kevin W. Sacherman , Signe Erickson , Hugo Peris , Eugene de Juan, JR.
Abstract: An implantable device for delivering a therapeutic agent to treat an ear of a patient includes a body having a distal end region and a proximal end region. The body defines, at least in part, a reservoir configured to contain the therapeutic agent. The device includes a shaft attached to the distal end region of the body and a lumen extending through the shaft having at least one inlet at a proximal end region in fluid communication with the reservoir and at least one outlet at a distal end region. Upon implantation of the body in a region of the ear, a length of the shaft is sufficient to extend from the body to at least the round window membrane of the ear. The device is configured to deliver the therapeutic agent to the ear from the reservoir via passive diffusion. Related devices and methods are described.
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公开(公告)号：US20240399126A1
公开(公告)日：2024-12-05
申请号：US18800665
申请日：2024-08-12
Applicant: Spiral Therapeutics Inc.
Inventor： Kevin W. Sacherman , Signe Erickson , Hugo Peris , Eugene de Juan, JR.
Abstract: An implantable device for delivering a therapeutic agent to treat an ear of a patient includes a body having a distal end region and a proximal end region. The body defines, at least in part, a reservoir configured to contain the therapeutic agent. The device includes a shaft attached to the distal end region of the body and a lumen extending through the shaft having at least one inlet at a proximal end region in fluid communication with the reservoir and at least one outlet at a distal end region. Upon implantation of the body in a region of the ear, a length of the shaft is sufficient to extend from the body to at least the round window membrane of the ear. The device is configured to deliver the therapeutic agent to the ear from the reservoir via passive diffusion. Related devices and methods are described.
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公开(公告)号：US20230183475A1
公开(公告)日：2023-06-15
申请号：US17923945
申请日：2021-05-12
Applicant: Spiral Therapeutics Inc.
Inventor： Eugene de Juan, JR. , Signe Erickson , Andrew Ayoob , Kathleen Farinas
CPC classification number: C08L71/00 , C08L77/04 , A61K9/06 , A61K9/0046 , A61K31/573 , A61P27/16
Abstract: Provided herein are polymer compositions and extended release otic agents. In one aspect, provided herein is a polymer composition including about 5% to about 15% by weight of the polymer composition of a functional polymer, wherein the functional polymer includes a first functional group, about 0.05% to about 0.6% by weight of the polymer composition of a crosslinker, wherein the crosslinker includes a second functional group, and water, wherein a crosslinking reaction can occur between the first functional group and the second functional group to form a gel, and wherein the polymer composition has a gelation time of about 45 seconds to about 60 minutes at a temperature of about 20° C.
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公开(公告)号：US20190321611A1
公开(公告)日：2019-10-24
申请号：US16388159
申请日：2019-04-18
Applicant: Spiral Therapeutics, Inc.
Inventor： Kevin W. Sacherman , Signe Erickson , Hugo Peris , Eugene de Juan, JR.
Abstract: An implantable device for delivering a therapeutic agent to treat an ear of a patient includes a body having a distal end region and a proximal end region. The body defines, at least in part, a reservoir configured to contain the therapeutic agent. The device includes a shaft attached to the distal end region of the body and a lumen extending through the shaft having at least one inlet at a proximal end region in fluid communication with the reservoir and at least one outlet at a distal end region. Upon implantation of the body in a region of the ear, a length of the shaft is sufficient to extend from the body to at least the round window membrane of the ear. The device is configured to deliver the therapeutic agent to the ear from the reservoir via passive diffusion. Related devices and methods are described.
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