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    INNER EAR DRUG DELIVERY DEVICES AND METHODS OF USE
    4.
    发明申请
    INNER EAR DRUG DELIVERY DEVICES AND METHODS OF USE 有权

    公开(公告)号：US20240399126A1

    公开(公告)日：2024-12-05

    申请号：US18800665

    申请日：2024-08-12

    Applicant: Spiral Therapeutics Inc.

    Inventor： Kevin W. Sacherman ,  Signe Erickson ,  Hugo Peris ,  Eugene de Juan, JR.

    IPC: A61M31/00 ,  A61M37/00

    Abstract: An implantable device for delivering a therapeutic agent to treat an ear of a patient includes a body having a distal end region and a proximal end region. The body defines, at least in part, a reservoir configured to contain the therapeutic agent. The device includes a shaft attached to the distal end region of the body and a lumen extending through the shaft having at least one inlet at a proximal end region in fluid communication with the reservoir and at least one outlet at a distal end region. Upon implantation of the body in a region of the ear, a length of the shaft is sufficient to extend from the body to at least the round window membrane of the ear. The device is configured to deliver the therapeutic agent to the ear from the reservoir via passive diffusion. Related devices and methods are described.

    TREATMENT OF OTIC DISEASES AND CONDITIONS
    7.
    发明申请
    TREATMENT OF OTIC DISEASES AND CONDITIONS 有权

    公开(公告)号：US20230067496A1

    公开(公告)日：2023-03-02

    申请号：US17797606

    申请日：2021-02-12

    Applicant: Spiral Therapeutics Inc.

    Inventor： Eugene de Juan, Jr. ,  Andrew Ayoob ,  Signe Erickson ,  Kathleen Farinas

    IPC: A61K9/06 ,  C07K16/22 ,  A61K45/06 ,  A61K9/00

    Abstract: Active agents that bind to VEGF or a VEGF receptor and reduce the severity of a condition associated with BLB disruption and/or angiogenesis, for example anti-VEGF antibodies or tyrosine kinase inhibitor small molecules, can be locally, regionally or systemically administered to an individual with an otic disease or condition, such as Méniére's Disease, Autoimmune Inner Ear Disease, sensorineural hearing loss and noise-induced hearing loss, to alleviate symptoms of the disease or condition, for example, due to edema and endolymphatic dysfunction. An effective amount of these compounds can be delivered by intratympanic or intracochlear administration. Other methods of administration include, but are not limited to, topical, parenteral, subcutaneous, intraperitoneal and intranasal. Formulations may be, for example, for immediate release, sustained release, or controlled release.

    VISUALIZATION DEVICES, SYSTEMS, AND METHODS FOR OTOLOGY AND OTHER USES
    8.
    发明申请
    VISUALIZATION DEVICES, SYSTEMS, AND METHODS FOR OTOLOGY AND OTHER USES 有权

    公开(公告)号：US20210231935A1

    公开(公告)日：2021-07-29

    申请号：US17155580

    申请日：2021-01-22

    Applicant: Spiral Therapeutics Inc.

    Inventor： Eugene de Juan ,  Signe Erickson ,  Vrad Levering

    IPC: G02B21/00 ,  G02B21/22

    Abstract: Devices, systems, and methods can be employed to facilitate indirect viewing into cavities such as, but not limited to, the middle ear space. Some embodiments have uses such as, but not limited to, facilitating visualization and procedures in the outer, middle, and/or inner ear in order to diagnose and/or treat disorders including, but not limited to, hearing loss and other ear disorders. In particular implementations, a surgical microscope is used in conjunction with an inverter lens and a distal lens. In some cases, the distal lens transverses a membrane or septum such as, but not limited to, the tympanic membrane. The distal lens can be an assembly combining two or more lenses, in some embodiments. For example, in some cases wide angle lenses, zoom lenses, lenses of other various shapes and/or prisms can be used in the distal lens.

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