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公开(公告)号：US20210228849A1
公开(公告)日：2021-07-29
申请号：US17155564
申请日：2021-01-22
Applicant: Spiral Therapeutics Inc.
Inventor： Eugene de Juan , Signe Erickson , Charles Limb , Hugo Peris , Nikhil Talreja , Andrew Ayoob
Abstract: Intra-tympanic injections of therapeutics into the inner ear can be used to treat conditions such as hearing loss. One or more stabilizing devices that define working channels can be temporarily implanted in the tympanic membrane. Purpose-built instruments such as endoscopes, forceps, and injections instruments can be passed through the working channels of the stabilizer devices to access the inner ear where the therapy can be administered. Afterwards, the stabilizing devices can be removed from the tympanic membrane and the tympanic membrane can heal, typically without the need for sutures.
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公开(公告)号：US12164095B2
公开(公告)日：2024-12-10
申请号：US17155564
申请日：2021-01-22
Applicant: Spiral Therapeutics Inc.
Inventor： Eugene de Juan , Signe Erickson , Charles Limb , Hugo Peris , Nikhil Talreja , Andrew Ayoob
IPC: A61M31/00 , A61B1/018 , A61B1/227 , A61B17/29 , A61B17/32 , A61B17/3205 , A61B17/34 , A61B18/04 , A61B18/14 , A61B18/20 , A61F2/958 , A61F11/20 , A61M37/00 , G02B21/00 , G02B21/22 , A61B17/00 , A61B18/00 , A61F2/18
Abstract: Intra-tympanic injections of therapeutics into the inner ear can be used to treat conditions such as hearing loss. One or more stabilizing devices that define working channels can be temporarily implanted in the tympanic membrane. Purpose-built instruments such as endoscopes, forceps, and injections instruments can be passed through the working channels of the stabilizer devices to access the inner ear where the therapy can be administered. Afterwards, the stabilizing devices can be removed from the tympanic membrane and the tympanic membrane can heal, typically without the need for sutures.
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公开(公告)号：US11662561B2
公开(公告)日：2023-05-30
申请号：US17155800
申请日：2021-01-22
Applicant: Spiral Therapeutics Inc.
Inventor： Eugene de Juan , Signe Erickson , Charles Limb , Hugo Peris , Andrew Ayoob , Vrad Levering
IPC: G02B21/00 , G02B21/22 , A61B1/018 , A61B1/227 , A61B17/29 , A61M31/00 , A61B17/34 , A61M37/00 , A61B17/32 , A61B18/04 , A61B18/20 , A61F2/958 , A61B17/3205 , A61B18/14 , A61F11/20 , A61B17/00 , A61B18/00 , A61F2/18
CPC classification number: G02B21/0012 , A61B1/018 , A61B1/227 , A61B17/29 , A61B17/3205 , A61B17/320068 , A61B17/3423 , A61B17/3468 , A61B17/3478 , A61B18/04 , A61B18/1485 , A61B18/20 , A61F2/958 , A61F11/20 , A61F11/202 , A61M31/00 , A61M31/002 , A61M37/0015 , G02B21/0032 , G02B21/22 , A61B2017/00115 , A61B2017/00787 , A61B2017/00867 , A61B2017/32007 , A61B2018/00327 , A61B2217/005 , A61F2002/183 , A61F2250/0067 , A61M2037/0023 , A61M2037/0046 , A61M2205/04 , A61M2210/0662 , A61M2210/0668
Abstract: Systems and methods can be employed for trans-tympanic membrane access to the middle ear for delivery of a therapeutic agent, for example, to the round window niche adjacent to the cochlea under direct visualization. The systems and methods can also be used to improve accessibility and visualization for various otological surgical procedures, such as, but not limited to, cholesteatoma removal, tympanic membrane repair and ossicular chain repair.
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公开(公告)号：US20210228237A1
公开(公告)日：2021-07-29
申请号：US17155800
申请日：2021-01-22
Applicant: Spiral Therapeutics Inc.
Inventor： Eugene de Juan , Signe Erickson , Charles Limb , Hugo Peris , Andrew Ayoob , Vrad Levering
IPC: A61B17/34
Abstract: Systems and methods can be employed for trans-tympanic membrane access to the middle ear for delivery of a therapeutic agent, for example, to the round window niche adjacent to the cochlea under direct visualization. The systems and methods can also be used to improve accessibility and visualization for various otological surgical procedures, such as, but not limited to, cholesteatoma removal, tympanic membrane repair and ossicular chain repair.
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公开(公告)号：US20250067966A1
公开(公告)日：2025-02-27
申请号：US18945752
申请日：2024-11-13
Applicant: Spiral Therapeutics Inc.
Inventor： Eugene de Juan , Signe Erickson , Charles Limb , Hugo Peris , Nikhil Talreja , Andrew Ayoob
IPC: G02B21/00 , A61B1/018 , A61B1/227 , A61B17/00 , A61B17/29 , A61B17/32 , A61B17/3205 , A61B17/34 , A61B18/00 , A61B18/04 , A61B18/14 , A61B18/20 , A61F2/18 , A61F2/958 , A61F11/20 , A61M31/00 , A61M37/00 , G02B21/22
Abstract: Intra-tympanic injections of therapeutics into the inner ear can be used to treat conditions such as hearing loss. One or more stabilizing devices that define working channels can be temporarily implanted in the tympanic membrane. Purpose-built instruments such as endoscopes, forceps, and injections instruments can be passed through the working channels of the stabilizer devices to access the inner ear where the therapy can be administered. Afterwards, the stabilizing devices can be removed from the tympanic membrane and the tympanic membrane can heal, typically without the need for sutures.
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Patent Agency Ranking
公开(公告)号：US12138436B2
公开(公告)日：2024-11-12
申请号：US17433401
申请日：2020-02-24
Applicant: Spiral Therapeutics, Inc.
Inventor： Kevin W. Sacherman , Andrew Ayoob , Signe Erickson , Hugo Peris , Charles Limb , Eugene De Juan, Jr.
Abstract: A system for delivering one or more therapeutics to a region of the ear, the region being internal to a tympanic membrane. The system includes a canal guide configured to be inserted within and fittingly engaged with walls of the ear canal and needle assembly having a flexible shaft sized to extend through the canal guide. The canal guide provides alignment of the needle assembly within the ear canal relative to the tympanic membrane. The canal guide includes a viewing lumen extending between a proximal end to a distal-most end of the canal guide and is sized to remain external to the tympanic membrane. The canal guide includes a guide lumen extending to a distal opening near the distal-most end of the canal guide. The guide lumen curves from a first axis to a second axis. Related devices, systems, and methods are provided.
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公开(公告)号：US20210228411A1
公开(公告)日：2021-07-29
申请号：US17155575
申请日：2021-01-22
Applicant: Spiral Therapeutics Inc.
Inventor： Eugene de Juan , Signe Erickson , Charles Limb , Vrad Levering
Abstract: Systems and methods can be employed for facilitating access and procedures in the outer, middle, and inner ear in order to diagnose or treat ear disorders including, but not limited to hearing loss and excessive ear wax. In some examples, the systems and methods include instruments and techniques that facilitate trans-tympanic membrane or trans-fibrous ring access to the middle ear. The systems and methods can also be used to improve accessibility for various otological surgical procedures, such as, but not limited to, cholesteatoma removal, tympanic membrane repair and ossicular chain repair.
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公开(公告)号：US20230258915A1
公开(公告)日：2023-08-17
申请号：US18138459
申请日：2023-04-24
Applicant: Spiral Therapeutics Inc.
Inventor： Eugene de Juan , Signe Erickson , Charles Limb , Hugo Peris , Andrew Ayoob , Vrad Levering
IPC: G02B21/00 , G02B21/22 , A61B1/018 , A61B1/227 , A61B17/29 , A61M31/00 , A61B17/34 , A61M37/00 , A61B17/32 , A61B18/04 , A61B18/20 , A61F2/958 , A61B17/3205 , A61B18/14 , A61F11/20
CPC classification number: G02B21/0012 , G02B21/0032 , G02B21/22 , A61B1/018 , A61B1/227 , A61B17/29 , A61M31/002 , A61B17/3468 , A61B17/3478 , A61M37/0015 , A61B17/320068 , A61B17/3423 , A61B18/04 , A61B18/20 , A61F2/958 , A61M31/00 , A61B17/3205 , A61B18/1485 , A61F11/20 , A61F11/202 , A61M2205/04 , A61M2210/0662 , A61B2017/00115
Abstract: Systems and methods can be employed for trans-tympanic membrane access to the middle ear for delivery of a therapeutic agent, for example, to the round window niche adjacent to the cochlea under direct visualization. The systems and methods can also be used to improve accessibility and visualization for various otological surgical procedures, such as, but not limited to, cholesteatoma removal, tympanic membrane repair and ossicular chain repair.
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公开(公告)号：US11467386B2
公开(公告)日：2022-10-11
申请号：US17708581
申请日：2022-03-30
Applicant: Spiral Therapeutics Inc.
Inventor： Eugene de Juan , Signe Erickson , Charles Limb , Hugo Peris , Andrew Ayoob , Vrad Levering
IPC: G02B21/00 , G02B21/22 , A61B1/018 , A61B1/227 , A61B17/29 , A61M31/00 , A61B17/34 , A61M37/00 , A61B17/32 , A61B18/04 , A61B18/20 , A61F2/958 , A61B17/3205 , A61B18/14 , A61F11/20 , A61B17/00 , A61B18/00 , A61F2/18
Abstract: Systems and methods can be employed for trans-tympanic membrane access to the middle ear for delivery of a therapeutic agent, for example, to the round window niche adjacent to the cochlea under direct visualization. The systems and methods can also be used to improve accessibility and visualization for various otological surgical procedures, such as, but not limited to, cholesteatoma removal, tympanic membrane repair and ossicular chain repair.
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公开(公告)号：US20220221700A1
公开(公告)日：2022-07-14
申请号：US17708581
申请日：2022-03-30
Applicant: Spiral Therapeutics Inc.
Inventor： Eugene de Juan , Signe Erickson , Charles Limb , Hugo Peris , Andrew Ayoob , Vrad Levering
IPC: G02B21/00 , G02B21/22 , A61B1/018 , A61B1/227 , A61B17/29 , A61M31/00 , A61B17/34 , A61M37/00 , A61B17/32 , A61B18/04 , A61B18/20 , A61F2/958 , A61B17/3205 , A61B18/14 , A61F11/20
Abstract: Systems and methods can be employed for trans-tympanic membrane access to the middle ear for delivery of a therapeutic agent, for example, to the round window niche adjacent to the cochlea under direct visualization. The systems and methods can also be used to improve accessibility and visualization for various otological surgical procedures, such as, but not limited to, cholesteatoma removal, tympanic membrane repair and ossicular chain repair.
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