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    AUTOBIOTIC COMPOSITIONS AND METHOD FOR PROMOTING HEALTHY GUT MICROBIOME
    2.
    发明申请
    AUTOBIOTIC COMPOSITIONS AND METHOD FOR PROMOTING HEALTHY GUT MICROBIOME 有权

    公开(公告)号：US20240415870A1

    公开(公告)日：2024-12-19

    申请号：US18815386

    申请日：2024-08-26

    Applicant: AXCESS GLOBAL SCIENCES, LLC

    Inventor： Gary MILLET ,  Matthew TITLOW

    IPC: A61K31/715 ,  A61K9/20 ,  A61K9/48 ,  A61K31/22

    Abstract: A method of administering an autobiotic composition that includes a prebiotic component and postbiotic component. The prebiotic component is a substance resistant to digestion in the stomach and small intestine and selectively fermentable by microorganisms in the large intestine. The postbiotic component is a short-chain fatty acid, such as butyric acid, lactic acid, succinic acid, or salt or ester thereof. The prebiotic component is advantageously delivered to the stomach and/or small intestine and the postbiotic is advantageously delivered to the large intestine. A seedbiotic component may form part of or be co-administered with the autobiotic composition. Enzymes may form part of or be co-administered with the autobiotic composition to enhance digestion of the prebiotic in the stomach and intestine and/or increase microbiome health. An exogenous ketone body component may form part of or be co-administered with the autobiotic composition.

    Structural and functional characteristics of yeast-derived polysaccharide inducing Treg cell
    4.
    发明授权
    Structural and functional characteristics of yeast-derived polysaccharide inducing Treg cell 有权

    公开(公告)号：US12161662B2

    公开(公告)日：2024-12-10

    申请号：US17285253

    申请日：2019-07-29

    Applicant: INSTITUTE FOR BASIC SCIENCE ,  POSTECH ACADEMY-INDUSTRY FOUNDATION

    Inventor： Sin-Hyeog Im ,  Verma Ravi ,  Changhon Lee

    IPC: A61K31/736 ,  A23L33/125 ,  A23L33/145 ,  A61K31/715 ,  A61K31/716 ,  A61K36/06 ,  A61K39/00 ,  A61P1/00 ,  A61P29/00 ,  A61P37/02 ,  C08B37/00 ,  C12N5/0783

    Abstract: The present invention relates to a yeast-derived polysaccharide inducing Treg cells and a use thereof and, more particularly, to a polysaccharide comprising mannan and β-glucan, an composition for immunomodulation comprising the polysaccharide as an active ingredient, a pharmaceutical composition or food comprising the polysaccharide as an active ingredient for prevention or treatment of immune disease or inflammatory disease, a method for preparation of regulatory T cells by using the polysaccharide, a cell therapeutic agent comprising the regulatory T cells prepared by the preparation method as an active ingredient, and a treatment method using same. Even at a low dose, the novel polysaccharide according to the present invention allows the production of tolerogenic antigen presenting cells through the β-glucan and mannan structure retained therein, whereby the novel polysaccharide can induce the differentiation or production of antigen-specific regulatory T cells (Treg cells) to modulate the target immune system with low adverse effects. Therefore, MGCP and the Treg cells induced by the polysaccharide are effective for preventing or treating immune disease or inflammatory disease.

    WATER-SOLUBLE DIETARY FIBER, USE THEREOF IN PREPARATION OF MEDICAMENT THAT PROMOTES METABOLISM OF ELLAGIC ACID INTO UROLITHIN A, AND PHARMACEUTICAL COMPOSITION
    5.
    发明申请
    WATER-SOLUBLE DIETARY FIBER, USE THEREOF IN PREPARATION OF MEDICAMENT THAT PROMOTES METABOLISM OF ELLAGIC ACID INTO UROLITHIN A, AND PHARMACEUTICAL COMPOSITION 有权

    公开(公告)号：US20240382515A1

    公开(公告)日：2024-11-21

    申请号：US18214162

    申请日：2023-06-26

    Applicant: ZHEJIANG UNIVERSITY

    Inventor： Shiguo CHEN ,  Laiming ZHANG ,  Haibo PAN ,  Xingqian YE ,  Donghong LIU ,  Tian DING

    IPC: A61K31/715 ,  A61P3/00

    Abstract: The present disclosure provides a water-soluble dietary fiber (WSDF), use thereof in preparation of a medicament that promotes metabolism of ellagic acid (EA) into urolithin A, and a pharmaceutical composition, and belongs to the technical field of biological pharmaceuticals. The WSDF provided by the present disclosure includes at least two components selected from the group consisting of gellan gum, guar gum, carrageenan, fructooligosaccharide, xylooligosaccharide, malto-oligosaccharide, pectin, β-glucan, polydextrose, sodium alginate, gum arabic, resistant dextrin, xanthan gum, tragacanth gum, and inulin. In the present disclosure, compounding the foregoing different combinations of the WSDF and EA to feed mice may significantly increase the average urolithin A content in mouse feces. Visibly, the WSDF alone or in combination with EA may improve metabotypes of the EA in the body and increase urolithin A content, providing a new means for treating diabetes, obesity, senescence and central nervous system lesions.

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