公开(公告)号：US20240382539A1

公开(公告)日：2024-11-21

申请号：US18229592

申请日：2023-08-02

Applicant: Zhejiang University

Inventor： Haibo PAN ,  Laiming ZHANG ,  Shiguo CHEN ,  Xingqian YE ,  Donghong LIU ,  Tian DING

IPC: A61K35/747 ,  A61K31/366 ,  A61K35/741 ,  A61K35/744 ,  A61K35/745 ,  A61P1/14

Abstract: The present disclosure provides use of an intestinal probiotic in preparation of a medicament that promotes metabolism of ellagic acid (EA) into urolithin A, a pharmaceutical composition and use thereof, and belongs to the technical field of biomedicine. In the present disclosure, probiotics capable of changing metabotypes of EA are selected from a plurality of probiotics. These probiotics alone or in combination can change an intestinal flora structure of a metabotype B and/or 0 population, thereby improving the efficiency of the metabolism of EA into urolithin A and increasing a yield of urolithin A. The present disclosure provides an intestinal probiotic for involving in and promoting the metabolism of EA into urolithin A, and provides a new idea for the treatment of diabetes, obesity, senescence, and diseases caused by central nervous system lesions and viral infection using urolithin A as an active pharmaceutical ingredient.

公开(公告)号：US20240382515A1

公开(公告)日：2024-11-21

申请号：US18214162

申请日：2023-06-26

Applicant: ZHEJIANG UNIVERSITY

Inventor： Shiguo CHEN ,  Laiming ZHANG ,  Haibo PAN ,  Xingqian YE ,  Donghong LIU ,  Tian DING

IPC: A61K31/715 ,  A61P3/00

Abstract: The present disclosure provides a water-soluble dietary fiber (WSDF), use thereof in preparation of a medicament that promotes metabolism of ellagic acid (EA) into urolithin A, and a pharmaceutical composition, and belongs to the technical field of biological pharmaceuticals. The WSDF provided by the present disclosure includes at least two components selected from the group consisting of gellan gum, guar gum, carrageenan, fructooligosaccharide, xylooligosaccharide, malto-oligosaccharide, pectin, β-glucan, polydextrose, sodium alginate, gum arabic, resistant dextrin, xanthan gum, tragacanth gum, and inulin. In the present disclosure, compounding the foregoing different combinations of the WSDF and EA to feed mice may significantly increase the average urolithin A content in mouse feces. Visibly, the WSDF alone or in combination with EA may improve metabotypes of the EA in the body and increase urolithin A content, providing a new means for treating diabetes, obesity, senescence and central nervous system lesions.

公开(公告)号：US20220227793A1

公开(公告)日：2022-07-21

申请号：US17617266

申请日：2020-06-11

Applicant: ZHEJIANG UNIVERSITY

Inventor： Tian DING ,  Dan WU ,  Mofei SHEN ,  Donghong LIU ,  Enbo XU

IPC: C07F7/00 ,  C01B37/00 ,  C25B1/04 ,  C25B13/00 ,  C25B9/19

Abstract: Disclosed are a zirconium-based metal-organic framework material and a preparation method thereof. Plasma-activated water or strong acid electrolyzed water is added to a raw material system for preparing a zirconium-based metal-organic framework material UiO-66, and they are then subjected to a reaction to obtain a crude product. The crude product is subjected to a post-treatment to obtain the zirconium-based metal-organic framework material UiO-66.

公开(公告)号：US20240199826A1

公开(公告)日：2024-06-20

申请号：US17909285

申请日：2022-03-11

Applicant: ZHEJIANG UNIVERSITY ,  JIANGNAN UNIVERSITY

Inventor： Tian DING ,  Mofei SHEN ,  Donghong LIU ,  Wei ZHAO ,  Jinsong FENG

IPC: C08J5/18 ,  C08K3/08 ,  C08K5/13

CPC classification number: C08J5/18 ,  C08K5/13 ,  C08J2383/04 ,  C08J2405/16 ,  C08K2003/0806 ,  C08K2201/011

Abstract: A method for preparing a sustained release antibacterial film includes: (1) mixing a cyclodextrin metal-organic framework (CD-MOF) material with a silver nitrate short-chain alcohol solution to prepare an intermediate material A; (2) mixing the intermediate material A with a caffeic acid short-chain alcohol solution to prepare an intermediate material B; (3) dispersing the intermediate material B in a solvent, adding a polydimethylsiloxane main agent and a PDMS auxiliary agent in sequence, and mixing well by stirring to obtain a casting solution; and (4) coating the casting solution on a film support material, conducting vacuum drying, and peeling off a film from the film support material to obtain the sustained-release antibacterial film. A mixed matrix-based film material in which the CD-MOF and the PDMS are physically blended is prepared based on CD-MOF and PDMS for the first time, and may be used in application researches of food, environment and other fields.

公开(公告)号：US20240122178A1

公开(公告)日：2024-04-18

申请号：US18277559

申请日：2022-03-11

Applicant: ZHEJIANG UNIVERSITY

Inventor： Tian DING ,  Mofei SHEN ,  Jinsong FENG ,  Donghong LIU ,  Shiguo CHEN ,  Enbo XU ,  Wenjun WANG ,  Huan CHENG

IPC: A01N37/38 ,  A01N25/10 ,  A01P1/00

CPC classification number: A01N37/38 ,  A01N25/10 ,  A01P1/00

Abstract: Disclosed are a caffeic acid-based composite material and a preparation method thereof. The method includes: exposing a cyclodextrin metal-organic framework material prepared from γ-cyclodextrin to a solution of caffeic acid in a short-chain alcohol to obtain a mixed material; and incubating the mixed material, wherein during the incubating, the cyclodextrin metal-organic framework material is in dynamic contact with the solution of caffeic acid in a short-chain alcohol. The prepared composite material includes a cyclodextrin metal-organic framework material and caffeic acid loaded on the cyclodextrin metal-organic framework material, wherein the cyclodextrin metal-organic framework material is prepared from γ-cyclodextrin. The caffeic acid is loaded in an amount of 15-18% of a total mass of the caffeic acid-based composite material. The caffeic acid is located in a cavity of the cyclodextrin metal-organic framework material.